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[ CAS No. 1202-66-0 ]

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2D
Chemical Structure| 1202-66-0
Chemical Structure| 1202-66-0
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Product Details of [ 1202-66-0 ]

CAS No. :1202-66-0MDL No. :MFCD01670887
Formula : C10H13NO2 Boiling Point : 424.1°C at 760 mmHg
Linear Structure Formula :-InChI Key :-
M.W :179.22Pubchem ID :121051
Synonyms :

Computed Properties of [ 1202-66-0 ]

TPSA : 49.3 H-Bond Acceptor Count : 2
XLogP3 : 1.1 H-Bond Donor Count : 2
SP3 : 0.30 Rotatable Bond Count : 3

Safety of [ 1202-66-0 ]

Signal Word:WarningClass:N/A
Precautionary Statements:P305+P351+P338UN#:N/A
Hazard Statements:H319Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1202-66-0 ]

  • Upstream synthesis route of [ 1202-66-0 ]
  • Downstream synthetic route of [ 1202-66-0 ]

[ 1202-66-0 ] Synthesis Path-Upstream   1~17

  • 1
  • [ 60-19-5 ]
  • [ 108-24-7 ]
  • [ 1202-66-0 ]
Reference: [1] Journal of the American Chemical Society, 2009, vol. 131, # 36, p. 13132 - 13141
[2] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 1, p. 478 - 487
[3] Archives of Biochemistry, 1959, vol. 83, p. 76,77
  • 2
  • [ 51-67-2 ]
  • [ 108-24-7 ]
  • [ 1202-66-0 ]
YieldReaction ConditionsOperation in experiment
86% With sodium hydrogencarbonate In tetrahydrofuran; water GK3-015 was prepared according to the following reaction scheme 12
Reference: [1] Patent: US9522908, 2016, B2, . Location in patent: Page/Page column 57
[2] Biochemical Pharmacology, 1998, vol. 55, # 1, p. 37 - 43
[3] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2014, vol. 53, # 1, p. 83 - 89
  • 3
  • [ 51-67-2 ]
  • [ 141-78-6 ]
  • [ 1202-66-0 ]
YieldReaction ConditionsOperation in experiment
99% at 90℃; for 24 h; Inert atmosphere General procedure: To a solution of tBuCO2H (3d) (30.9 mg, 0.30 mmol) in EtOAc (3.0 mL) at room rtemperature was added 3-amino-1-phenylbutane (1) (48.7 μL, 0.30 mmol). The reaction mixture was refluxed (90 °C) for 24 h and then it was evaporated the solvent. The crude product was purified preparative thin layer chromatography on silica (hexane/EtOAc/35percent NH3 = 25/75/1) to afford the corresponding acetoamide 2 (57.0 mg, 99percent yield) as a colorless oil.
Reference: [1] Tetrahedron Letters, 2017, vol. 58, # 12, p. 1181 - 1184
  • 4
  • [ 14383-56-3 ]
  • [ 1202-66-0 ]
Reference: [1] Patent: US6352993, 2002, B1, . Location in patent: Page column 11
  • 5
  • [ 51-67-2 ]
  • [ 75-36-5 ]
  • [ 1202-66-0 ]
Reference: [1] Journal of Antibiotics, 2001, vol. 54, # 10, p. 827 - 830
  • 6
  • [ 51-67-2 ]
  • [ 1694-31-1 ]
  • [ 1202-66-0 ]
Reference: [1] European Journal of Organic Chemistry, 2017, vol. 2017, # 11, p. 1526 - 1539
  • 7
  • [ 51-67-2 ]
  • [ 64-19-7 ]
  • [ 1202-66-0 ]
Reference: [1] Tetrahedron, 1983, vol. 39, # 20, p. 3253 - 3260
[2] Journal of Natural Products, 2006, vol. 69, # 10, p. 1379 - 1383
  • 8
  • [ 72131-33-0 ]
  • [ 1202-66-0 ]
Reference: [1] Patent: US4258058, 1981, A,
  • 9
  • [ 51-67-2 ]
  • [ 1202-66-0 ]
Reference: [1] European Journal of Organic Chemistry, 2017, vol. 2017, # 11, p. 1526 - 1539
  • 10
  • [ 51-67-2 ]
  • [ 60759-49-1 ]
  • [ 1202-66-0 ]
Reference: [1] Tetrahedron Letters, 1981, vol. 22, # 13, p. 1257 - 1258
[2] Tetrahedron, 1983, vol. 39, # 20, p. 3253 - 3260
  • 11
  • [ 58484-75-6 ]
  • [ 1202-66-0 ]
  • [ 161644-20-8 ]
Reference: [1] Chemistry Letters, 1998, # 2, p. 111 - 112
[2] Bulletin of the Chemical Society of Japan, 1997, vol. 70, # 5, p. 965 - 975
  • 12
  • [ 51-67-2 ]
  • [ 75-36-5 ]
  • [ 1202-66-0 ]
  • [ 14383-56-3 ]
  • [ 20284-85-9 ]
Reference: [1] Tetrahedron, 2009, vol. 65, # 8, p. 1618 - 1629
  • 13
  • [ 51-67-2 ]
  • [ 128459-09-6 ]
  • [ 1202-66-0 ]
Reference: [1] Tetrahedron Letters, 1990, vol. 31, # 2, p. 243 - 246
  • 14
  • [ 51-67-2 ]
  • [ 75178-12-0 ]
  • [ 1202-66-0 ]
  • [ 101001-90-5 ]
Reference: [1] Chemistry Letters, 1980, p. 563 - 566
  • 15
  • [ 58484-75-6 ]
  • [ 613-21-8 ]
  • [ 1202-66-0 ]
  • [ 161644-20-8 ]
Reference: [1] Chemistry Letters, 1998, # 2, p. 111 - 112
  • 16
  • [ 64318-28-1 ]
  • [ 1202-66-0 ]
Reference: [1] Patent: US9522908, 2016, B2,
  • 17
  • [ 51-67-2 ]
  • [ 72-89-9 ]
  • [ 1202-66-0 ]
Reference: [1] Biochemistry, 2014, vol. 53, # 49, p. 7777 - 7793
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