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Chemical Structure| 1203575-93-2 Chemical Structure| 1203575-93-2

Structure of 1203575-93-2

Chemical Structure| 1203575-93-2

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Product Details of [ 1203575-93-2 ]

CAS No. :1203575-93-2
Formula : C10H10F3NO3
M.W : 249.19
SMILES Code : O=C(N(OC)C)C1=CC=CC(OC(F)(F)F)=C1
MDL No. :MFCD28165918

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Application In Synthesis of [ 1203575-93-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1203575-93-2 ]

[ 1203575-93-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 50823-90-0 ]
  • [ 6638-79-5 ]
  • [ 1203575-93-2 ]
YieldReaction ConditionsOperation in experiment
85% With tert.-butylhydroperoxide; copper(II) acetate monohydrate; calcium carbonate; In acetonitrile; at 80℃; for 24h; General procedure: An oven-dried 15 mL glass vial with a magnetic stirrer bar was charged with Cu(OAc)2·H2O (12 mg, 6 mol%), N,O-dimethylhydroxylamine hydrochloride (2; 117 mg, 1.2 mmol), the respective benzyl alcohol 1 (1 mmol), aq 70% TBHP (0.17 mL, 1.2 mmol), CaCO3 (120 mg, 1.2 mmol) in MeCN (1 mL). The glass vial was flushed with N2 three times and the contents were stirred at r.t. for 1 h. Then the reaction mixture was stirred for 24 h at 80 C. After completion of the reaction, the mixture was cooled to r.t. All volatiles were removed under vacuum. The product was extracted with EtOAc (20 mL) and the organic layer was washed with sat. aq NaHCO3 (20 mL), dried (Na2SO4), and the solvent removed under vacuum. The Weinreb amide product 3 was purified by column chromatography (silica gel, 100-200 mesh) using a gradient of petroleum ether (bp 60-80 C) and EtOAc. All the amides were identified by GC-MS, 1H, and 13C NMR spectroscopic analysis.
 

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