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Chemical Structure| 1204333-53-8 Chemical Structure| 1204333-53-8

Structure of 1204333-53-8

Chemical Structure| 1204333-53-8

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Product Details of [ 1204333-53-8 ]

CAS No. :1204333-53-8
Formula : C13H18BrNO3
M.W : 316.20
SMILES Code : CC(C)(OC(NCCOC1=CC=CC=C1Br)=O)C
MDL No. :MFCD18382015

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Application In Synthesis of [ 1204333-53-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1204333-53-8 ]

[ 1204333-53-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 95-56-7 ]
  • [ 158690-56-3 ]
  • [ 1204333-53-8 ]
YieldReaction ConditionsOperation in experiment
80.1% With potassium carbonate; In N,N-dimethyl-formamide; at 60℃; for 12h;Inert atmosphere; To a mixture of 2-bromophenol (30.2 mL, 260 mmol, 1 eq) and 2-((tert-butoxycarbonyl) amino)ethyl 4-methylbenzenesulfonate (82 g, 260 mmol, leq) in N,N-dimethylfonnamide (500 mL) was added potassium carbonate (71.8 g, 520 mmol, 2 eq) in one portion at 25 Cunder nitrogen. The mixture was stirred at 60 C for 12 hr. The mixture was cooled to 25 C, The residue was poured into ice- water (w/w = 1 /I ) (1 OOOmL.) and stirred for 3 min. The aqueous phase was extracted with ethyl acetate (500 mL * 3). The combined organic phase was dried with anhydrous sodium sulfate, filtered and concentrated in vacuum. The residue was purified by column chromatography (silica, petroleum ether/ethyl acetate = 1/0 to 3/1) to afford the title compound (70.1 g, 80.1 % yield) as yellow oil. H XMR. (400 MHz, CDCh-d) 5 ppm 1 .49 (s, 9 H)3.62 (q, 2 H) 4.11 (t, 2 H) 5.15 (br s, 1 H) 6.86 - 6.96 (m, 2 H) 7.27 - 7.32 (m, 1 H) 7.57 (dd, 1 H).
 

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