Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 120871-73-0 | MDL No. : | MFCD27923656 |
Formula : | C12H19NO3 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | FMKOLWIQHDLUPE-UHFFFAOYSA-N |
M.W : | 225.28 | Pubchem ID : | 67513550 |
Synonyms : |
|
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
69% | for 4 h; Inert atmosphere | Step 1, Method B: tert-butyl 3-aUyl-4-oxopyrrolidine-l-carboxylate[0181] A solution of 1-tert-butyl 3-methyl 4-oxopyrrolidine-l,3-dicarboxylate (48.65 g, 0.20 mol), allyl alcohol (300 mL), and dibutyltin oxide (5.0 g, 20 mmol) in anhydrous toluene (800 mL) was refluxed for 20 h under a Dean-Stark trap with portionwise removal of solvent (total of 200 mL) over the first 6 hours, followed by addition of more allyl alcohol (75 mL) at the end of the first 6 hours. The reaction mixture was concentrated, dissolved in minimal methylene chloride, and loaded onto a silica gel column (700 mL volume) and eluted with methylene chloride, 10percent, then 15percent, then 20percent ethyl acetate/methylene chloride to afford 3- allyl 1-tert-butyl 4-oxopyrrolidine-l,3-dicarboxylate (48.6 g, 90percent) as a pale pink oil (NMR and MS as above). This compound (48.47g, 0.18 mol) was dissolved in anhydrous tetrahydrofuran (200 mL) and added to a stirred solution of Pd(PPh3)4 (4.16 g, 3.6 mmol) in anhydrous tetrahydrofuran (400 mL) under nitrogen, stirred for 4 h, and concentrated. The residue was dissolved in heptane and loaded onto a silica gel column (1000 mL volume) and eluted with 60:35:5 heptane/methylene chloride/ethyl acetate to afford tert-butyl 3-allyl-4- oxopyrrolidine-l-carboxylate (27.93, 69percent) as a pale yellow oil (NMR and MS as above). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
57% | In 2,2,2-trifluoroethanol; at 20℃; for 96h;Inert atmosphere; | Step 2: (3R,4S)-tert-butyl 3-acetamido-4-allyl-3-(tert-butylcarbamoyl)pyrrolidine-l- carboxylate[0182] A stirred mixture of tert-butyl 3-allyl-4-oxopyrrolidine-l-carboxylate (13.23 g, 58.7 mmol) and ammonium acetate (11.95 g, 155 mmol) in 2,2,2-trifluoroethanol (25 mL) under nitrogen was treated with t-butylisonitrile (12.25 mL, 106 mmol), then stirred at room temperature for 4 days and concentrated. The residue was partitioned between water (100 mL) and methylene chloride (200 mL), and the aqueous layer was extracted with methylene chloride (2 x 75 mL). The combined organic solution was washed with water and saturated aqueous sodium chloride (100 mL each), dried (Na2S04), and concentrated to an off-white solid. This was recrystallized twice with ethyl acetate (150 mL each) to afford a portion of the title product (8.36 g) as a white solid. The combined mother liquors were concentrated, dissolved in minimum methylene chloride, and loaded onto a silica gel column (650 mL volume). This was eluted with 60%, then 70%, then 90%> ethyl acetate/heptane to afford additional product (3.84 g). Total yield of (3R,4S)-tert-butyl 3-acetamido-4-allyl-3-(tert- butylcarbamoyl)pyrrolidine-l-carboxylate was 12.22 g (57%) as a white solid. NMR(CDC13) delta 6.30 - 6.70 (m, 2 H), 5.60 -5.75 (m, 1 H), 4.95 - 5.10 (m, 2 H), 3.94 (d, J=11.5 Hz, 1 H), 3.75 (d, J=11.5 Hz, 1 H), 3.60 (m, 1 H), 3.00 - 3.20 (m, 2 H), 2.20 - 2.30 (m, 1 H), 2.00 (s, 3 H), 1.80 - 1.90 (m, 1 H), 1.44 (s, 9 H), 1.33 (s, 9 H). MS (m + 1): 368.3; MS (m - bu +1): 312.1; MS (m - boc + 1): 268.3. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
51% | In 2,2,2-trifluoroethanol; at 60℃;Inert atmosphere; | Example 46: preparation of (3R,4S)-3-amino-4-(3-boronopropyl)-l-(4- fluorobenzoyl)pyrrolidine-3-carboxylic acidStep 1: tert-Butyl 4-allyl-3-[ (2-nitrophenyl)carbamoyl]-3-[ (trifluoroacetyl) amino] - pyrrolidine- 1-carboxylate[0261] While under nitrogen, a stirred mixture of tert-butyl 3-allyl-4-oxopyrrolidine-l- carboxylate (600 mg, 2.66 mmol), ammonium trifluoroacetate (698 mg, 5.33 mmol) and 2- nitrophenyl isocyanide (690 mg, 4.6 mmol) in 2,2,2-trifluoroethanol (2.7 mL) was placed in a 60 C oil bath and stirred overnight. After cooling to room temperature, the mixture was diluted with ethyl acetate (40 mL), washed with water (3 x 20 mL) and the combined aqueous phase was re-extracted with ethyl acetate (20 mL). The combined organic phase was washed with saturated aqueous sodium chloride (20 mL), dried over Na2S04 and concentrated under reduced pressure. Purification by silica gel chromatography (90 g column, 0-5% ethyl acetate in methylene chloride) gave tert-butyl 4-allyl-3-[(2-nitrophenyl)carbamoyl]-3- [(trifluoroacetyl)amino] -pyrrolidine- 1-carboxylate (665 mg, 51%, 3:2 mixture ofdiastereomers) as an amber gum. LC-MS ESI + MS found for C2iH25F3N406 m/z 509.0 (M + Na). LC-MS ESI" MS found for C2iH25F3N406 m/z 485.1 (M - H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
69% | tetrakis(triphenylphosphine) palladium(0); In tetrahydrofuran; for 4h;Inert atmosphere;Product distribution / selectivity; | Step 1, Method B: tert-butyl 3-aUyl-4-oxopyrrolidine-l-carboxylate[0181] A solution of 1-tert-butyl 3-methyl 4-oxopyrrolidine-l,3-dicarboxylate (48.65 g, 0.20 mol), allyl alcohol (300 mL), and dibutyltin oxide (5.0 g, 20 mmol) in anhydrous toluene (800 mL) was refluxed for 20 h under a Dean-Stark trap with portionwise removal of solvent (total of 200 mL) over the first 6 hours, followed by addition of more allyl alcohol (75 mL) at the end of the first 6 hours. The reaction mixture was concentrated, dissolved in minimal methylene chloride, and loaded onto a silica gel column (700 mL volume) and eluted with methylene chloride, 10%, then 15%, then 20% ethyl acetate/methylene chloride to afford 3- allyl 1-tert-butyl 4-oxopyrrolidine-l,3-dicarboxylate (48.6 g, 90%) as a pale pink oil (NMR and MS as above). This compound (48.47g, 0.18 mol) was dissolved in anhydrous tetrahydrofuran (200 mL) and added to a stirred solution of Pd(PPh3)4 (4.16 g, 3.6 mmol) in anhydrous tetrahydrofuran (400 mL) under nitrogen, stirred for 4 h, and concentrated. The residue was dissolved in heptane and loaded onto a silica gel column (1000 mL volume) and eluted with 60:35:5 heptane/methylene chloride/ethyl acetate to afford tert-butyl 3-allyl-4- oxopyrrolidine-l-carboxylate (27.93, 69%) as a pale yellow oil (NMR and MS as above). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
50 g | With Dess-Martin periodane; In dichloromethane; at 10 - 20℃; | 58 g (0.26 mol) of 3-allyl-4-hydroxypyrrolidine-1-carboxylic acid tert-butyl ester was dissolved in dichloromethane,Add 120 g (0.28 mol) of Dess Martin reagent in batches at 10-20 C, and react at room temperature.TLC detects the end of the reaction.Add sodium thiosulfate solution and saturated sodium bicarbonate solution to quench the reaction and separate the liquid.The dichloromethane layer was washed with water. The crude product was subjected to flash column chromatography to obtain 50 g of the product. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
A solution of chloroform (26.86 mL, 333 mmol) and TMS-Cl (32.86 mL, 257.1 mmol) in anhydrous THF (300 mL) was cooled to -78 C. After stirring for 10 min, LHMDS (1M in THF, 249 mL, 249 mmol) was added at a rate such that the temperature remained below -60 C. (approximately 30 min). After stirring an additional 30 min at -60 to -70 C. (reaction mixture becomes cloudy) the solution was warmed to -20 C. (reaction mixture becomes clear) and treated with <strong>[120871-73-0]tert-butyl-3-allyl-4-oxopyrrolidine-1-carboxylate</strong> (3, 30 g, 133.2 mmol) in DMF (90 mL) and tetrabutylammonium acetate (3.69 g, 12.24 mmol) in DMF (90 mL) at a rate such that the internal reaction temperature remained below -20 C. (reaction becomes cloudy). After the addition was complete, the reaction mixture was warmed to room temperature with stirring until the ketone starting material was consumed (by TLC), then poured into saturated aqueous NH4Cl and extracted with EtOAc (3*100 mL). The combined organic layers were washed successively with saturated aqueous NH4Cl and saturated aqueous NaCl (2*80 mL), dried over MgSO4, filtered and concentrated. While under nitrogen, the crude TMS protected intermediate was dissolved in dry THF (300 mL), cooled to 0 C. and carefully treated with acetic acid (7.5 mL, 130.9 mmol) and TBAF (1 M in THF, 133.2 mL, 133.2 mmol) dropwise. After the addition was complete, the reaction was stirred an additional 10 min at 0 C. then poured into saturated aqueous NaHCO3 and extracted with EtOAc (3*100 mL). The combined organic layers were washed with saturated aqueous NaCl, dried over MgSO4, filtered and concentrated to afford the crude alcohol intermediate. The crude alcohol was dissolved in dioxane (200 mL), cooled to 0 C., and treated with a pre-cooled (0 C.) solution of sodium azide (14.04 g, 399.5 mmol) and NaOH (15.98 g, 399.5 mmol) in water (200 mL) dropwise. The resulting reaction mixture was allowed to warm to room temperature with stirring overnight then quenched with of saturated aqueous NH4Cl and was extracted with EtOAc (500 mL). The aqueous layer was separated and extracted with EtOAc (2*300 mL). The combined organic layers were washed with water and saturated aqueous NaCl, dried over MgSO4, filtered and concentrated to give crude trans-4-allyl-3-azido-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid (4, crude 45 g) which was used without further purification. 1H-NMR (CDCl3, 400 MHz): deltaH: 5.80 (1H, m), 5.06 (2H, m), 4.05 (1H, dd, J=9.9, 4.9 Hz), 3.59 (2H, m), 3.22 (1H, dd, J=11.6, 4.4 Hz), 3.08 (1H, dd, J=11.0, 5.2 Hz), 2.24-2.04 (2H, m), 1.65 (1H, br s, OH) and 1.45 (9H, s). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
83% | With sulfur trioxide pyridine complex; N-ethyl-N,N-diisopropylamine; In dichloromethane; dimethyl sulfoxide; at 3 - 10℃; for 0.25h;Inert atmosphere; | While under an atmosphere of dry nitrogen, an ice-cooled solution of tert-butyl-trans-3-allyl-4-hydroxypyrrolidine-1-carboxylate (2, 60 g, 264 mmol) and diisopropylethylamine (132.2 mL, 799.8 mmol) in dichloromethane (750 mL, 0.35 M) was treated dropwise with a solution of sulfur trioxide pyridine complex (94.95 g, 596.6 mmol) in anhydrous DMSO (750 mL) at a rate to keep the reaction mixture below 10 C. After the addition was complete, the mixture was stirred at 3 C. for 15 min, quenched with water (380 mL) and extracted with ethyl acetate (500 mL, then 2*300 mL). The combined organic solution was washed twice with water (200 mL), once with saturated aqueous sodium chloride (200 mL), dried (MgSO4) and concentrated. The resulting crude oil was distilled at 105 C. (0.4 mm Hg) to afford tert-butyl 3-allyl-4-oxopyrrolidine-1-carboxylate (3, 58 g, 83% yield) as a colorless oil. 1H-NMR (CDCl3, 400 MHz): deltaH: 5.74 (1H, m), 5.09 (2H, m), 4.02 (1H, m), 3.88 (1H, d, J=19.4 Hz), 3.68 (1H, d, J=19.4 Hz), 3.31 (1H, dd, J=9.4, 8.3 Hz), 2.65 (1H, m), 2.54 (1H, m), 2.18 (1H, m) and 1.45 (9H, s). |
83% | With sulfur trioxide pyridine complex; N-ethyl-N,N-diisopropylamine; In dichloromethane; dimethyl sulfoxide; at 10℃; for 0.25h;Inert atmosphere; | While under an atmosphere of dry nitrogen, an ice-cooled solution of tert-butyl-trans-3-allyl-4-hydroxypyrrolidine-1-carboxylate (12, 60 g, 264 mmol) and diisopropylethylamine (132.2 mL, 799.8 mmol) in dichloromethane (750 mL, 0.35 M) was treated dropwise with a solution of sulfur trioxide pyridine complex (94.95 g, 596.6 mmol) in anhydrous DMSO (750 mL) at a rate to keep the reaction mixture below 10 C. After the addition was complete, the mixture was stirred at 3 C. for 15 min, quenched with water (380 mL) and extracted with ethyl acetate (500 mL, then 2*300 mL). The combined organic solution was washed twice with water (200 mL), once with saturated aqueous sodium chloride (200 mL), dried (MgSO4) and concentrated. The resulting crude oil was distilled at 105 C. (0.4 mm Hg) to afford racemic tert-butyl 3-allyl-4-oxopyrrolidine-1-carboxylate (13, 58 g, 83% yield) as a colorless oil. 1H-NMR (CDCl3, 400 MHz): deltaH: 5.74 (1H, m), 5.09 (2H, m), 4.02 (1H, m), 3.88 (1H, d, J=19.4 Hz), 3.68 (1H, d, J=19.4 Hz), 3.31 (1H, dd, J=9.4, 8.3 Hz), 2.65 (1H, m), 2.54 (1H, m), 2.18 (1H, m) and 1.45 (9H, s). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
A solution of chloroform (26.86 mL, 333 mmol) and IMS-Ci (32.86 mL, 257.1mmol) in anhydrous THF (300 mL) was cooled to -78 C. After stirring for 10 mm,LiFIIVIDS (1M in IHF, 249 mL, 249 mmol) was added at a rate such that the temperature remained below -60 C (approximately 30 mm). After stirring an additional 30 mm at -60 to -70 C (reaction mixture becomes cloudy) the solution was warmed to -20 C (reaction mixture becomes clear) and treated with <strong>[120871-73-0]tert-butyl-3-allyl-4-oxopyrrolidine-1-carboxylate</strong>(3, 30 g, 133.2 mmol) in DMF (90 mL) and tetrabutylammonium acetate (3.69 g, 12.24 mmol) in DMF (90 mL) at a rate such that the internal reaction temperature remainedbelow - 20 C (reaction becomes cloudy). After the addition was complete, the reaction mixture was warmed to room temperature with stirring until the ketone starting material was consumed (by TLC), then poured into saturated aqueous NFT4C1 and extracted withEtOAc (3 x 100 mL). The combined organic layers were washed successively withsaturated aqueous NH4C1 and saturated aqueous NaC1 (2 x 80 mL), dried over MgSO4, filtered and concentrated.While under nitrogen, the crude TIVIS protected intermediate was dissolved in dry 1kW (300 mL), cooled to 0 C and carefully treated with acetic acid (7.5 mL, 130.9mmol) and TBAF (1 M in 1HF, 133.2 mL, 133.2 mmol) dropwise. After the addition was complete, the reaction was stirred an additional 10 mm at 0 CC then poured into saturated aqueous NaHCO3 and extracted with EtOAc (3 x 100 mL). The combined organic layers were washed with saturated aqueous NaC1, dried over MgSOt, filtered and concentrated to afford the crude alcohol intermediate.The crude alcohol was dissolved in dioxane (200 mL), cooled to 0 CC, and treated with a pre-cooled (0 C) solution of sodium azide (14.04 g, 399.5 mmol) and NaOH(15.98 g, 399.5 mmol) in water (200 mL) dropwise. The resulting reaction mixture was allowed to warm to room temperature with stirring overnight then quenched with of saturated aqueous NH4C1 and was extracted with EtOAc (500 mL). The aqueous layer was separated and extracted with EtOAc (2 x 300 mL). The combined organic layers were washed with water and saturated aqueous NaC1, dried over MgSO4, filtered and concentrated to give crude trans-4-allyl-3 -azido- 1 -(tert-butoxycarbonyl)pyrrolidine-3 -carboxylic acid (4, crude 45g) which was used without further purification. ?H-NMR (CDC13, 400 MHz): oH: 5.80 (1H, m), 5.06 (2H, m), 4.05 (1H, dd, J = 9.9, 4.9 Hz), 3.59 (2H, m), 3.22 (1H, dd, J = 11.6, 4.4 Hz), 3.08 (1H, dd, J = 11.0, 5.2 Hz), 2.24-2.04 (2H, m), 1.65 (1H, br s, OH) and 1.45 (9H, s). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
63% | In methanol; at 0 - 20℃; for 48h;Inert atmosphere; | While under an atmosphere of dry nitrogen, a solution of ketone (13, 79.3 g, 352 mmol) and ammonium acetate (135.7 g, 1,759 mmol) in methanol (200 mL) was cooled to 0 C. and treated with tert-butyl isocyanide (80.2 mL, 704 mol) and stirred at room temperature for 48 h. The resulting slurry was concentrated, diluted with a 1:2 mixture of ethyl acetate and water (300 mL). After stirring for 1 h, the precipitate was filtered and washed with water (100 mL) and ice-cold ether (2*50 mL) and air dried. The crude product, which is predominately the syn-isomer (about 10:1), was diluted with ethyl acetate (400 mL), isopropyl alcohol (400 mL) and ethanol (2 mL), then warmed to 70 C. After stirring for an additional 2 h, the solution was allowed to cool to room temperature with continued stirring overnight, filtered and washed with ice-cooled ether (2*50 mL) and dried in the oven at 60 C. overnight to give racemic (syn) tert-butyl-3-acetamido-4-allyl-3-(tert-butylcarbamoyl)pyrrolidine-1-carboxylate (14, 82.1 g, 63% yield.) as a white powder. |
Tags: 120871-73-0 synthesis path| 120871-73-0 SDS| 120871-73-0 COA| 120871-73-0 purity| 120871-73-0 application| 120871-73-0 NMR| 120871-73-0 COA| 120871-73-0 structure
[ 138021-97-3 ]
tert-Butyl 3-allyl-4-oxopiperidine-1-carboxylate
Similarity: 0.92
[ 129321-62-6 ]
tert-Butyl 7-oxo-5-azaspiro[2.4]heptane-5-carboxylate
Similarity: 0.95
[ 1217633-41-4 ]
(R)-tert-Butyl 2-isopropyl-4-oxopyrrolidine-1-carboxylate
Similarity: 0.92
[ 1212437-79-0 ]
(S)-tert-Butyl 2-isopropyl-4-oxopyrrolidine-1-carboxylate
Similarity: 0.92
[ 138021-97-3 ]
tert-Butyl 3-allyl-4-oxopiperidine-1-carboxylate
Similarity: 0.92
[ 858643-95-5 ]
tert-Butyl 3-acetylpyrrolidine-1-carboxylate
Similarity: 0.91
[ 129321-62-6 ]
tert-Butyl 7-oxo-5-azaspiro[2.4]heptane-5-carboxylate
Similarity: 0.95
[ 1217633-41-4 ]
(R)-tert-Butyl 2-isopropyl-4-oxopyrrolidine-1-carboxylate
Similarity: 0.92
[ 1212437-79-0 ]
(S)-tert-Butyl 2-isopropyl-4-oxopyrrolidine-1-carboxylate
Similarity: 0.92
[ 138021-97-3 ]
tert-Butyl 3-allyl-4-oxopiperidine-1-carboxylate
Similarity: 0.92
[ 858643-95-5 ]
tert-Butyl 3-acetylpyrrolidine-1-carboxylate
Similarity: 0.91
[ 129321-62-6 ]
tert-Butyl 7-oxo-5-azaspiro[2.4]heptane-5-carboxylate
Similarity: 0.95
[ 1217633-41-4 ]
(R)-tert-Butyl 2-isopropyl-4-oxopyrrolidine-1-carboxylate
Similarity: 0.92
[ 1212437-79-0 ]
(S)-tert-Butyl 2-isopropyl-4-oxopyrrolidine-1-carboxylate
Similarity: 0.92
[ 1374673-89-8 ]
(S)-3-Acetyl-1-Boc-pyrrolidine
Similarity: 0.91
[ 1251570-77-0 ]
(S)-tert-Butyl 3-(3-methylbutanoyl)pyrrolidine-1-carboxylate
Similarity: 0.91
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
Home
* Country/Region
* Quantity Required :
* Cat. No.:
* CAS No :
* Product Name :
* Additional Information :