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Chemical Structure| 120871-73-0
Chemical Structure| 120871-73-0
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Product Details of [ 120871-73-0 ]

CAS No. :120871-73-0 MDL No. :MFCD27923656
Formula : C12H19NO3 Boiling Point : -
Linear Structure Formula :- InChI Key :FMKOLWIQHDLUPE-UHFFFAOYSA-N
M.W : 225.28 Pubchem ID :67513550
Synonyms :

Safety of [ 120871-73-0 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 120871-73-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 120871-73-0 ]
  • Downstream synthetic route of [ 120871-73-0 ]

[ 120871-73-0 ] Synthesis Path-Upstream   1~3

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  • [ 120871-73-0 ]
YieldReaction ConditionsOperation in experiment
69% for 4 h; Inert atmosphere Step 1, Method B: tert-butyl 3-aUyl-4-oxopyrrolidine-l-carboxylate[0181] A solution of 1-tert-butyl 3-methyl 4-oxopyrrolidine-l,3-dicarboxylate (48.65 g, 0.20 mol), allyl alcohol (300 mL), and dibutyltin oxide (5.0 g, 20 mmol) in anhydrous toluene (800 mL) was refluxed for 20 h under a Dean-Stark trap with portionwise removal of solvent (total of 200 mL) over the first 6 hours, followed by addition of more allyl alcohol (75 mL) at the end of the first 6 hours. The reaction mixture was concentrated, dissolved in minimal methylene chloride, and loaded onto a silica gel column (700 mL volume) and eluted with methylene chloride, 10percent, then 15percent, then 20percent ethyl acetate/methylene chloride to afford 3- allyl 1-tert-butyl 4-oxopyrrolidine-l,3-dicarboxylate (48.6 g, 90percent) as a pale pink oil (NMR and MS as above). This compound (48.47g, 0.18 mol) was dissolved in anhydrous tetrahydrofuran (200 mL) and added to a stirred solution of Pd(PPh3)4 (4.16 g, 3.6 mmol) in anhydrous tetrahydrofuran (400 mL) under nitrogen, stirred for 4 h, and concentrated. The residue was dissolved in heptane and loaded onto a silica gel column (1000 mL volume) and eluted with 60:35:5 heptane/methylene chloride/ethyl acetate to afford tert-butyl 3-allyl-4- oxopyrrolidine-l-carboxylate (27.93, 69percent) as a pale yellow oil (NMR and MS as above).
Reference: [1] Patent: WO2012/58065, 2012, A1, . Location in patent: Page/Page column 49
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Reference: [1] Patent: WO2012/58065, 2012, A1,
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  • [ 114214-49-2 ]
  • [ 120871-73-0 ]
Reference: [1] Patent: US2017/121352, 2017, A1,
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