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CAS No. : | 121148-01-4 | MDL No. : | MFCD01861781 |
Formula : | C11H20N2O4 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | IOLQYMRFIIVPMQ-YUMQZZPRSA-N |
M.W : | 244.29 | Pubchem ID : | 5200425 |
Synonyms : |
|
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With dmap; triethylamine; In dichloromethane; at 0 - 20℃; | To a solution of N-Boc-cis-4-amino-L-proline methyl ester, 21-1 , (10.0 g, 35.61 mmol) in CH2CI2 cooled to 0 0C were sequentially added TEA (14.88 ml_, 106.80 mmol), DMAP (10 mg) and terephthaloyl chloride (3.61 g, 17.80 mmol) and the reaction was stirred overnight at room temperature. Water and ethyl acetate were added, the organic layer was separated, washed with 10 % citric acid, aqueous NaHCO3 and brine, dried over <n="141"/>anhydrous MgSO4, filtered and concentrated in vacuo. Purification by silica gel chromatography provided intermediate 21-2 as a white solid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
75% | Step A: methyl-r2S.4SVl-BOC-4-rr4.4-dimethylcyclohexyl')aminol pyrrolidine- 2-carboxylate; [579] To methyl (2S,4S)-l-Boc-4-aminopyrrolidine-2-carboxylate (1.07 g, 4.38 mmol) and dimethylcyclohexanone (0.66g, 5.25 mmol) in DCE (20 mL) was added dropwise NaBH(OAc) (1.39 g, 6.57 mmol) at it. The reaction mixture was stirred at it for 4 h, a saturated NaHCO aqueous solution was added, and extracted with DCM (50 mL X 2) and EtOAc. The organic extracts were washed with brine, dried over MgSO 4 , filtered, and concentrated in vacuo. The obtained residue was purified by column chromatography (eluent, EtO Ac/Hex = 1/2) to give the title compound (1.16 g, 75 %).[580] MS[M+H] = 355(M+1) | |
75% | With acetic anhydride; In 1,2-dichloro-ethane; at 20℃; for 4h; | Methyl(2S,4S)-1-Boc-4-aminopyrrolidine-2-carboxylate (1.07 g, 4.38 mmol) obtained in Preparation 1 and 4,4-dimethylcyclohexanone (0.66 g, 5.25 mmol) were dissolved in DCE (10 ml), and NaBH(OAc)3 (1.39 g, 6.57 mmol) was added thereto at room temperature. After the reaction mixture was stirred at room temperature for 4 hours, the organic extracts were extracted with a saturated NaHCO3 aqueous solution. The extracted organic solution was dried over MgSO4, filtered, and concentrated in vacuo. The obtained residue was purified by column chromatography (eluent: EtOAc/Hex=1/2) to give the title compound (1.16 g, 75%).MS [M+H]=355 (M+1) |
75% | With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20℃; for 4h; | Example 1: N-{(3 S £ S )-l-[(3 S ,4 R )-l- tert - butyl-4-(4-chlorophenyl)pyrrolidin-3-yl]carbonyl}-5-[(4-methylpiperazin-l-yl)car bonyl]pyrrolidin-3-yl}- N -(4,4-dimethylcyclohexyl)acetamide TFA salt[461] TFA salt of[462][463] Step A: Methyl (2 S .4 S s)-l-BOC-4-[(4.4-dimethylcvclohexyls)amino1pyrrolidine-2-carboxylate[464] Methyl (2S,4S)-l-Boc-4-aminopyrrolidine-2-carboxylate (1.07 g, 4.38 mmol) obtained in Preparation 1 and 4,4-dimethylcyclohexanone(0.66 g, 5.25 mmol) were dissolved in DCE (10 ml), and NaBH(OAc)3 (1.39 g, 6.57 mmol) was added thereto at room temperature. After the reaction mixture was stirred at room temperature for 4 hours, the organic extracts were extracted with a saturated NaHCO3 aqueous solution. The extracted organic solution was dried over MgSO4, filtered, and concentrated in vacuo. The obtained residue was purified by column chromatography (eluent: EtOAc/ Hex = 1/2) to give the title compound (1.16 g, 75 %).[465] MS [M+H] = 355 (M+ 1) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
55% | With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20℃; for 6h; | Step A: 2-methyl-f2S.4SVl-BOC-4-rf4 .4 -difluorocyclohexyttaminoi pyrrolidine- carboxylate; [674] To a solution of 4,4-Difluoro cyclohexanone prepared in Preparation Example A2-3, and methyl (2S,4S)-l-Boc-4-aminopyrrolidine-2-carboxylate (29g, 120mmol) prepared in Preparation Example Al-I in DCE was added NaBH(OAc) (37g, 180mmol), and stirred at rt for 6 h. After the reaction finished, the solvent was concentrated in vacuo, NaHCO aqueous solution was added, extracted with EtOAc, and the organic layer was dried over MgSO 4 , concentrated in vacuo. The residue was purified by column chro- matography (eluent: EtOAc/Hex = 1/4) to isolate 2-methyl-(2S,4S)-l-BOC-4-[(4 - fluorocyclohex-S-ene-l-y^aminolpyrrolidine-carboxylate, whereby to give the title compound (23g, 55%). [675] MS[M+H] = 363 (M+l) [676] |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
57% | Step A: 1-BOC 2-methylf2 S A S V4-rfcis-4-methylcyclohexyl*)amino1 pyrrolidine- 2-carboxylate; [718] To a solution of methyl (2S,4S)-l-Boc-4-aminopyrrolidine-2-carboxylate (1.07 g, 4.38 mmol) prepared in Preparation Example Al-I and 4-methylcyclohexanone in DCE (30 ml) was added dropwise NaBH(OAc) (1.39 g, 6.57 mmol) at rt. The reaction mixture was stirred at rt for 4 h, a saturated NaHCO aqueous solution was added, and extracted with DCM (50 mL X 2) and EtOAc. The organic extracts were washed with brine, dried over MgSO 4 , filtered, and concentrated in vacuo. The residue was purified by column chromatography (eluent, EtOAc/Hex = 1/2) to isolate cis and trans compounds, whereby to give the title compound (0.84 g, 57%). [719] MS[M+H] = 341 (M+l) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
76% | With triethylamine;dmap; In dichloromethane; at 0 - 20℃; for 18h; | To a solution of the N-Boc protected pyrrolidine amine shown above (948 mg, 3.881 mmol) in DCM (40 ml) at 0 C was added triethylamine (2.7 ml, 19.405 mmol) and DMAP (47 mg, 0.388 mmol). Isoquinoline-5-sulphonyl chloride hydrochloride (1.021 g, 3.881 mmol) was added in one portion and the resulting solution warmed to rt and stirred for 18 h. Saturated NAHC03 (40 ml) was added and the aqueous layer extracted with DCM (3 x 40 ml). Organic layers were combined, dried (MgSO4), concentrated and the crude purified by silica column chromatography (EtOAc) to give the desired product as an oil (1.278 g, 76%). LH NMR (CDC13) 8 1.31, 1.34 (9H, 2 x s), 1.64-1. 82 (1H, m), 2.10-2. 38 (1H, m), 3.24- 3.35 (2H, m), 3.73 (3H, s), 3.95-4. 22 (2H, m), 6.35-6. 65 (1H, m), 7.71-7. 76 (1H, m), 8.24-8. 27 (1H, m), 8. 37-8.41 (1H, m), 8.46-8. 49 (1H, m), 8.74-8. 79 (1H, m), 9.40 (1H, s). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
1) Methyl (2S,4S)-(N-Boc)-4-aminoprolinate is prepared from methyl (2S,4S)-4-azidoprolinate according to T. R. Webl in J. Org. Chem., 1991, 56, 3009. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With methanol; lithium hydroxide; water; In tetrahydrofuran; at 20℃; | To a solution of cz's-Boc-aminoprolinemethyl ester (43.5g, 155 mmol) in750 mL THF, and 63 mL methanol was added lithium hydroxide (17.95 g, 750mmol) in 500 mL water. The reaction mixture was stirred at roomtemperature overnight. The organics were removed under reduced pressure ,and the pH was adjusted to 5-6 using 10% HC1. The aqueous solution wasused as is for the next step. LC/MS: 231 (M+ +1).To a solution of cz's-Boc-aminoprolinecarboxylic acid (« 40 g, 174 mmol) as a crude reaction mixture from previous step cooled to 0C was added sodium carbonate (32.76 g, 309 mmol). Dissolve FMOC-C1 (46g, 178 mmol) in 1,4-dioxane (500 mL). Combine the dioxane solution to the aqueous solution. Stirthe reaction mixture at room temperature for 5 h. Remove organics underreduced pressure. Extract the aqueous solution with ether to remove excessFMOC-C1 and discard organic layer. Adjust pH to 2-3 with con HC1. Extractaqueous with ethyl acetate 3 X 400 mL, combine fractions and dry overMgSCk, filter and remove solvent under reduced pressure. Coevaporate thematerial 3 X with chloroform to afford desired product (78.8 g, 100%) as awhite solid and use as is for the next step. 1H NMR (300 MHz, CDCls): 6 7.78(d, J= 9.1 Hz, 2H), 7.59 (d, J= 9.2 Hz, 2H), 7.45 (m, 4H), 5.11-4.92 (bs, 1H), 4.58-4.18 (bs, 6H), 3.81 (m, 1H), 3.42 (m, 1H), 2.50-2.15 (bs, 2H), 1.43 (s, 9H).LC/MS:453(M+ + 1). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
(3) The above-mentioned compound (7.99 g) was dissolved in methanol (150 mL). The mixture was stirred under a hydrogen atomosphere (1 atm) in the presence of 10% palladium/carbon (2 g). The reaction mixture was filtrated and the filtrate was concentrated under reduced pressure to give methyl (2S,4S)-4-amino-1-tert-butoxycarbonylpyrrolidine-2-carboxylate (7.23 g) as an oil. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With triethylamine; In tetrahydrofuran; water; | (1) Methyl (2S,4S)-4-amino-1-tert-butoxycarbonylpyrrolidine-2-carboxylate [product of Reference Example 5(3), 2.4 g] and triethylamine (2.0 mL) were dissolved in tetrahydrofuran (20 mL), and benzoyl chloride (1.1 mL) was added thereto. The mixture was stirred for 1 hr. The reaction mixture was added to water and extracted with ethyl acetate. The extract was washed with saturated aqueous sodium hydrogencarbonate solution and dried. The solvent was evaporated under reduced pressure and the residue was purified by silica gel chromatography to give methyl (2S,4S)-4-benzoylamino-1-tert-butoxycarbonylpyrrolidine-2-carboxylate (1.63 g) as a white solid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With triethylamine; In dichloromethane; at 0 - 20℃; | The title compound of Example 21 (2.5 g, 10.2 mmol) was dissolved in DCM (100 mL) at 0 0C. TEA (2.13 mL, 15.3 mmol) was added and the mixture was stirred for 10 min, to which isophthaloyl dichloride (1.02 g, 5 mmol) was added. The reaction mixture was stirred for 1 hour at 0 0C, then slowly warmed up to room temperature and stirred overnight. Water was added to quench the reaction. The two phases were separated and the aqueous phase extracted by DCM twice. The combined organic phase was washed by HCl solution (IM), saturated NaHCO3 solution and brine. The organic phase was dried over sodium sulfate and concentrated under reduced pressure to give the title compound as a white solid. 1H NMR (CDCl3): consistent with proposed structure. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
57% | With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20℃; for 4h; | Methyl(2S,4S)-1-Boc-4-aminopyrrolidine-2-carboxylate (1.07 g, 4.38 mmol) obtained in Preparation 1 and 4-methylcyclohexanone were dissolved in DCE (30 mL) and NaBH(OAc)3 (1.39 g, 6.57 mmol) was added thereto at room temperature. After the reaction solution was stirred for 4 hours at room temperature, saturated NaHCO3 aqueous solution was added thereto and the solution was extracted with DCM (50 mL×2) and EtOAc. The extracted organic solution was washed with brine, dried over MgSO4, filtered and concentrated in vacuo. Cis- and trans-compounds were separated from the obtained residue by column chromatography (eluent: EtOAc/Hex=1/2) to give the title compound (0.84 g, 57%).MS [M+H]=341 (M+1) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
55% | With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20℃; for 6h; | Methyl(2S,4S)-1-Boc-4-aminopyrrolidine-2-carboxylate (29 g, 120 mmol) obtained in Preparation 1 and 4,4-difluoro-cyclohexanone (19.31 g, 144 mmol) obtained in Preparation 5 was dissolved in DCE. NaBH(OAc)3 (37 g, 180 mmol) was added thereto. The reaction solution was stirred for 6 hours at room temperature. After the reaction was completed, the solution was concentrated in vacuo and NaHCO3 aqueous solution was added thereto. The solution was extracted with EtOAc, dried over MgSO4, concentrated in vacuo and purified by column chromatography (eluent: EtOAc/Hex=1/4) to give the title compound (23.66 g, 55%) separated from methyl (2S,4S)-1-BOC-4-[(4'-fluorocyclohex-3-en-1-yl)amino]pyrrolidine-2-carboxylate.MS [M+H]=363 (M+1) |
55% | Step A: Methyl (2 S A SVl-BOC-4-r(4.4-difluorocyclohexyls)aminolpyrrolidine-2-carboxylate[610] Methyl (2S,4S)-l-Boc-4-aminopyrrolidine-2-carboxylate (29 g, 120 mmol) obtained in Preparation 1 and 4,4-difTuoro-cyclohexanone (19.31 g, 144 mmol) obtained in Preparation 5 was dissolved in DCE. NaBH(OAc)3 (37 g, 180 mmol) was added thereto. The reaction solution was stirred for 6 hours at room temperature. After the reaction was completed, the solution was concentrated in vacuo and NaHCO3 aqueous solution was added thereto. The solution was extracted with EtOAc, dried over MgSO4 , concentrated in vacuo and purified by column chromatography (eluent: EtO Ac/Hex = 1/4) to give the title compound (23.66 g, 55 %) separated from methyl (2S,4S)-l-BOC-4-[(4'-fluorocyclohex-3-en-l-yl)amino]pyrrolidine-2-carboxylate.[611] MS [M+H] = 363 (M+ 1 ) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
57% | Step A: Methyl (2 S A SVl-BOC-4-r(cis-4-methylcyclohexyls)aminolpyrrolidine-2-carboxylate[572] Methyl (2S,4S)-l-Boc-4-aminopyrrolidine-2-carboxylate (1.07 g, 4.38 mmol) obtained in Preparation 1 and 4-methylcyclohexanone were dissolved in DCE (30 mL) and NaBH(OAc)3 (1.39 g, 6.57 mmol) was added thereto at room temperature. After the reaction solution was stirred for 4 hours at room temperature, saturated NaHCO3 aqueous solution was added thereto and the solution was extracted with DCM (50 mL X 2) and EtOAc. The extracted organic solution was washed with brine, dried over MgSO4, filtered and concentrated in vacuo. Cis- and trans- compounds were separated from the obtained residue by column chromatography (eluent: EtO Ac/Hex = 1/2) to give the title compound (0.84 g, 57 %).[573] MS[M+H] = 341 (M+ 1) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
50% | With methanol; sodium tris(acetoxy)borohydride; at 20℃;Inert atmosphere; | (d) (2S,4S)-4-Dimethylamino-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester To a solution of the product of the previous step (28 g, 57 mmol) and formaldehyde (20 g, 240 mmol) in methanol (500 mL) was added sodium triacetoxyborohydride (36 g, 170 mmol) in portions at RT and the reaction mixture was stirred at RT overnight under nitrogen and then concentrated. The residue was washed with water and extracted with DCM (2*500 mL). The organic layer was washed with water and brine, dried over sodium sulfate, concentrated, and purified by silica gel chromatography (eluted with petroleum ether:EtOAc 1:2, 1% NH4OH) to give the title product (8 g, 50% yield) as a clear oil. 1H NMR (CDCl3, 400) delta (ppm) 4.09 (m, 2H), 3.73 (s, 3H), 3.53 (m, 1H), 2.58 (m, 2H), 2.26 (s, 6H), 1.88 (m, 1H), 1.42 (m, 9H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Intermediate 1A5: (25,45)-I -(tert-Butoxycarbonyl)-4-(methylsulfonamido)pyrrolidine-2-carboxylic acida) (25,45)-I -tert-butyl 2-methyl 4-(methylsulfonam ido)pyrrolidine-1 ,2-dicarboxylateA mixture of (2S,4S)-1 -tert-butyl 2-methyl 4-aminopyrrolidine-1 ,2-dicarboxylate (CAS registry121148-01 -4) (250 mg, 1.02 mmol) in DMF (5 ml) was dropwise treated with Et3N (285 uL,2.05 mmol) at 0C. The resulting mixture was stirred for 5 mm at 0C then niethanesWfonychorde (CAS registry 124-63-0) (80 uL, 1.02 mmol) was added. The solution became orange and the temperature was allowed to reach rt. Stirring was continued at rt for 4 d. The reaction mixture was washed with sat. aq.NaHCO3 soln. and extracted with DCM, the organic layer was dried by passing it through a phase separating cartridge and was evaporated in vacuo to afford a yellow oil (282 mg, 85% yield, crude).1H NMR (400 MHz, DMSO-d6): O 7.42 - 7.32 (m, 1 H) 4.15 (t, 1 H) 3.95 - 3.80 (m, 1 H) 3.71 (dd, 1 H) 3.676-3.56 (m, 3 H) 3.12-3.00 (m, 1 H) 2.60-2.53 (m, 1 H) 1.84-1.66 (m, 1 H) 1.42 - 1.26 (m, 9 H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
General procedure: To a solution of compound 3 (0.72 g, 2.0 mmol) and 4-Methylmorpholine (0.61 g, 6. 0 mmol) in dichloromethane (50 mL), HOBt (0.32 g, 2.4 mmol) and EDCI (0.49 g, 2.4 mmol) was added, and the mixture was stirred at room temperature for 0.5 h. After compound 4a was added, the solution was stirred overnight. The solvent was evaporated, and the obtained residue was extracted with ethyl acetate. The combined extracts were washed with saturated NaHCO3, 1 M aqueous HCl, brine, dried over anhydrous MgSO4, and concentrated to yield the crude product which was purified by column chromatography eluting with PE/EA (1:1 v/v) to give compound 5a as white solid (0.58 g, yield: 46.2%); |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
General procedure: To a solution of compound 3 (0.72 g, 2.0 mmol) and 4-Methylmorpholine (0.61 g, 6. 0 mmol) in dichloromethane (50 mL), HOBt (0.32 g, 2.4 mmol) and EDCI (0.49 g, 2.4 mmol) was added, and the mixture was stirred at room temperature for 0.5 h. After compound 4a was added, the solution was stirred overnight. The solvent was evaporated, and the obtained residue was extracted with ethyl acetate. The combined extracts were washed with saturated NaHCO3, 1 M aqueous HCl, brine, dried over anhydrous MgSO4, and concentrated to yield the crude product which was purified by column chromatography eluting with PE/EA (1:1 v/v) to give compound 5a as white solid (0.58 g, yield: 46.2%); |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
General procedure: To a solution of compound 3 (0.72 g, 2.0 mmol) and 4-Methylmorpholine (0.61 g, 6. 0 mmol) in dichloromethane (50 mL), HOBt (0.32 g, 2.4 mmol) and EDCI (0.49 g, 2.4 mmol) was added, and the mixture was stirred at room temperature for 0.5 h. After compound 4a was added, the solution was stirred overnight. The solvent was evaporated, and the obtained residue was extracted with ethyl acetate. The combined extracts were washed with saturated NaHCO3, 1 M aqueous HCl, brine, dried over anhydrous MgSO4, and concentrated to yield the crude product which was purified by column chromatography eluting with PE/EA (1:1 v/v) to give compound 5a as white solid (0.58 g, yield: 46.2%); |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
58% | To a solution of azido compound 5 (1.5 g, 5.5 mmol) dissolved in dry MeOH (25 mL), 10% palladium on charcoal (300 mg, 20% w/w) was added, the resulting reaction mixture stirred under hydrogen gas at 50 psi for 3 h and the reaction was monitored by TLC. Aftercompletion of reaction, it was filtered trough celite and water and methanol (1:1, 10 mL) were added. 2 N LiOH (15 mL) was further added to the reaction mixture and stirred for 30 min. Methanol was evaporated under reduced pressure and the resulting mixture was neutralised with dil. HCl. Solvents were evaporated and the residue was suspended in methanol and filtered. The supernatant collected was evaporated in vacuo to obtain the corresponding amino acid.The amino acid obtained was dissolved in 1, 4-dioxane:water (1:1),and NaHCO3 (3.6 g, 43.4 mmol) was added to ensure an alkaline pH.The resulting reaction mixture was stirred at room temperature for 30 min and Fmoc-Cl (1.33 g, 5.1 mmol) was added in portions. Thereaction mixture was stirred overnight at room temperature and monitored by TLC. Upon completion of reaction, the reaction mixture was slightly acidified by addition of Dowex H+ resin andthe resin was subsequently filtered off. The dioxane was evaporated under vacuum and ethyl acetate was added. The product was extracted in ethyl acetate. The organic extracts were washed with brine and dried over sodium sulfate. The solvents were evaporated in vacuo and the product was washed repeatedly by petroleum ether and diethyl ether to give title compound Z (1.13 g, 58%) as a solid yellowish foam. [a]20D 69.60 (c 0.050, CHCl3). 1H NMR(200 MHz, CDCl3) delta: 7.74 (m, 2H), 7.57 (m, 2H), 7.40 (m, 4H), 5.80 (m,1H), 4.49 (m, 2H), 4.34 (m, 3H), 4.20 (m, 1H), 3.53 (m, 2H), 2.38 (m,1H), 1.50 & 1.44 (s, 9H). 13C NMR (50 MHz, CDCl3) delta: 174.5.156.7,156.0, 143.8, 142.6, 141.3, 127.8, 120.0, 82.4, 67.1, 58.4, 47.1, 28.3. 13CDEPT (50 MHz, CDCl3) delta: 125.8, 125.2, 122.3, 118.1, 65.2, 56.5, 51.8,45.2, 31.7, 26.4. HRMS (ESI): m/z calculated for C25H28N2O6:452.1947; Observed: [M++Na] 475.1832. |
Tags: 121148-01-4 synthesis path| 121148-01-4 SDS| 121148-01-4 COA| 121148-01-4 purity| 121148-01-4 application| 121148-01-4 NMR| 121148-01-4 COA| 121148-01-4 structure
[ 254881-77-1 ]
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P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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