Alternatived Products of [ 121219-17-8 ]
Product Details of [ 121219-17-8 ]
CAS No. : | 121219-17-8 |
MDL No. : | |
Formula : |
C17H18F2
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
260.32
|
Pubchem ID : | - |
Synonyms : |
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Safety of [ 121219-17-8 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 121219-17-8 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 121219-17-8 ]
- 1
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[ 367-11-3 ]
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[ 51554-95-1 ]
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[ 121219-17-8 ]
- 2
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[ 51554-95-1 ]
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[ 121219-17-8 ]
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[ 121218-76-6 ]
- 3
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[ 76287-49-5 ]
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[ 121219-17-8 ]
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[ 121235-87-8 ]
- 4
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[ 7295-44-5 ]
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[ 121219-17-8 ]
- 5
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[ 51554-95-1 ]
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[ 121219-16-7 ]
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[ 121219-17-8 ]
Yield | Reaction Conditions | Operation in experiment |
19.7 g |
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In tetrahydrofuran; water; for 5h;Inert atmosphere; Reflux; |
The compounds of the formula (I-3-1) A reaction vessel 20.0 g (0.0881 mol), compound 15.3 g(0.0969 mole) of the formula (I-2-1), carbonate potassium 18.3g (0.132 mol), tetrahydrofuran120mL, the water 120mL was added, and the inside of the system was replaced with nitrogen.Tetrakis (triphenylphosphine) palladium (0) 1.02 g (0.881 mmol) was added and heated to refluxfor 5 hours. Toluene was added and the aqueous was washed with brine, to give the compound19.7 g (0.0757 mole) of the formula was purified by column chromatography (silica gel) (I-3-2). |
- 6
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[ 38573-88-5 ]
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[ 121219-12-3 ]
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[ 121219-17-8 ]
Yield | Reaction Conditions | Operation in experiment |
72.8% |
With tetrakis(triphenylphosphine) palladium(0); sodium hydrogencarbonate; In N,N-dimethyl acetamide; at 100℃; for 8h;Inert atmosphere; |
In a 3 L four-necked flask purged with nitrogen, 148.3 g of <strong>[121219-12-3]4-pentylphenylboronic acid</strong>, 102 g of 1-bromo-2,3-difluorobenzene, 5.56 g of tetrakistriphenylphosphine palladium (0) complex and 270 g of hydrogen carbonate Sodium and 750 ml of N, N-dimethylacetamide were added, and the mixture was stirred at 100 ° C. for 8 hours. The completion of the reaction was confirmed with a gas chromatograph (GC), and the system was cooled to room temperature. 1 L of water was added to the reaction system and stirring was carried out, 1 L of heptane was added thereto, and the mixture was vigorously stirred. The organic layer was separated and then extracted twice with 1 L of heptane. After washing the obtained heptane solution twice with 300 ml of water, the solvent was distilled off, and purification was carried out using 250 g of silica gel using heptane as a solvent, to obtain 100 g of the desired product as a colorless transparent liquid . Yield 72.8percent. GC purity 97.7percent. M + 260. |