Home Cart 0 Sign in  

[ CAS No. 121219-17-8 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 121219-17-8
Chemical Structure| 121219-17-8
Structure of 121219-17-8 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Quality Control of [ 121219-17-8 ]

Related Doc. of [ 121219-17-8 ]

Alternatived Products of [ 121219-17-8 ]

Product Details of [ 121219-17-8 ]

CAS No. :121219-17-8 MDL No. :
Formula : C17H18F2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 260.32 Pubchem ID :-
Synonyms :

Safety of [ 121219-17-8 ]

Signal Word: Class:
Precautionary Statements: UN#:
Hazard Statements: Packing Group:

Application In Synthesis of [ 121219-17-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 121219-17-8 ]

[ 121219-17-8 ] Synthesis Path-Downstream   1~6

  • 1
  • [ 367-11-3 ]
  • [ 51554-95-1 ]
  • [ 121219-17-8 ]
  • 2
  • [ 51554-95-1 ]
  • [ 121219-17-8 ]
  • [ 121218-76-6 ]
  • 3
  • [ 76287-49-5 ]
  • [ 121219-17-8 ]
  • [ 121235-87-8 ]
  • 5
  • [ 51554-95-1 ]
  • [ 121219-16-7 ]
  • [ 121219-17-8 ]
YieldReaction ConditionsOperation in experiment
19.7 g With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In tetrahydrofuran; water; for 5h;Inert atmosphere; Reflux; The compounds of the formula (I-3-1) A reaction vessel 20.0 g (0.0881 mol), compound 15.3 g(0.0969 mole) of the formula (I-2-1), carbonate potassium 18.3g (0.132 mol), tetrahydrofuran120mL, the water 120mL was added, and the inside of the system was replaced with nitrogen.Tetrakis (triphenylphosphine) palladium (0) 1.02 g (0.881 mmol) was added and heated to refluxfor 5 hours. Toluene was added and the aqueous was washed with brine, to give the compound19.7 g (0.0757 mole) of the formula was purified by column chromatography (silica gel) (I-3-2).
  • 6
  • [ 38573-88-5 ]
  • [ 121219-12-3 ]
  • [ 121219-17-8 ]
YieldReaction ConditionsOperation in experiment
72.8% With tetrakis(triphenylphosphine) palladium(0); sodium hydrogencarbonate; In N,N-dimethyl acetamide; at 100℃; for 8h;Inert atmosphere; In a 3 L four-necked flask purged with nitrogen, 148.3 g of <strong>[121219-12-3]4-pentylphenylboronic acid</strong>, 102 g of 1-bromo-2,3-difluorobenzene, 5.56 g of tetrakistriphenylphosphine palladium (0) complex and 270 g of hydrogen carbonate Sodium and 750 ml of N, N-dimethylacetamide were added, and the mixture was stirred at 100 ° C. for 8 hours. The completion of the reaction was confirmed with a gas chromatograph (GC), and the system was cooled to room temperature. 1 L of water was added to the reaction system and stirring was carried out, 1 L of heptane was added thereto, and the mixture was vigorously stirred. The organic layer was separated and then extracted twice with 1 L of heptane. After washing the obtained heptane solution twice with 300 ml of water, the solvent was distilled off, and purification was carried out using 250 g of silica gel using heptane as a solvent, to obtain 100 g of the desired product as a colorless transparent liquid . Yield 72.8percent. GC purity 97.7percent. M + 260.
Same Skeleton Products
Historical Records