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Chemical Structure| 1216720-69-2 Chemical Structure| 1216720-69-2

Structure of SCH79797 2HCl
CAS No.: 1216720-69-2

Chemical Structure| 1216720-69-2

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SCH79797 2HCl is a Potent, selective non-peptide PAR1 antagonist.

Synonyms: SCH 79797 (hydrochloride); SCH79797 dihydrochloride

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Product Details of SCH79797 2HCl

CAS No. :1216720-69-2
Formula : C23H27Cl2N5
M.W : 444.40
SMILES Code : NC1=C2C3=C(N(CC4=CC=C(C(C)C)C=C4)C=C3)C=CC2=NC(NC5CC5)=N1.[H]Cl.[H]Cl
Synonyms :
SCH 79797 (hydrochloride); SCH79797 dihydrochloride
MDL No. :MFCD04039788

Safety of SCH79797 2HCl

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Related Pathways of SCH79797 2HCl

GPCR

Isoform Comparison

Biological Activity

Description
SCH79797 dihydrochloride is a highly potent and selective nonpeptide protease activated receptor 1 (PAR1) antagonist. It inhibits the binding of a high-affinity thrombin receptor-activating peptide to PAR1 with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 dihydrochloride also inhibits thrombin-induced platelet aggregation with an IC50 of 3 μM. Moreover, it has antiproliferative and pro-apoptotic effects, and limits myocardial ischemia/reperfusion injury in rat hearts. Additionally, SCH79797 dihydrochloride potently prevents PAR1 activation in vascular smooth muscle cells, endothelial cells, and astrocytes[1][2][3][4].

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