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Chemical Structure| 1220631-45-7 Chemical Structure| 1220631-45-7

Structure of 1220631-45-7

Chemical Structure| 1220631-45-7

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Product Details of [ 1220631-45-7 ]

CAS No. :1220631-45-7
Formula : C7H2Cl2N4
M.W : 213.02
SMILES Code : N#CC1=CN=C2C(Cl)=CC(Cl)=NN21
MDL No. :N/A

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Application In Synthesis of [ 1220631-45-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1220631-45-7 ]

[ 1220631-45-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 446273-59-2 ]
  • [ 33142-21-1 ]
  • [ 1220631-46-8 ]
  • [ 1220631-45-7 ]
YieldReaction ConditionsOperation in experiment
IF: Preparation of 8-bromo-6-chloroimidazo[l,2-b]pyridazine-3-carbonitrile and 6,8- dichloroimidazo[l,2-b]pyridazine-3-carbonitrile[00239] A suspension of ID-I and 1D-2 (8.7 g, 31.6 mmol) in CHCl3 (500 mL) was treated with POCI3 (35.3 mL, 380 mmol) and heated to reflux for 3 days. The resulting solution was cooled to room temperature and poured into cold saturated aqueous NaHCO3 (1 L). Solid Na2CO3 was added until neutral pH was achieved. The resulting layers were separated and the aqueous layer was extracted with CHCl3 (1 L). The combined organics were dried with Na2SO4, filtered and concentrated to dryness to afford a mixture of IF-I and 1F-2 as a yellow powder (5.6 g, 68.9 %). [00240] IF-I: HPLC: Rt = 2.53 min. (YMC S5 ODS 4.6 x 50 mm, 10-90% aqueous methanol containing 0.2% H3PO4, 4 min gradient, monitored at 220 nm); MS (ES): m/z = 213 [M+H]+.[00241] 1F-2: HPLC: Rt = 2.67 min. (YMC S5 ODS 4.6 x 50 mm, 10-90% aqueous methanol containing 0.2% H3PO4, 4 min gradient, monitored at 220 nm); MS (ES): m/z = 258.9 [M+H]+.
 

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