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Chemical Structure| 1221119-68-1 Chemical Structure| 1221119-68-1

Structure of 1221119-68-1

Chemical Structure| 1221119-68-1

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Product Details of [ 1221119-68-1 ]

CAS No. :1221119-68-1
Formula : C8H8FNO3
M.W : 185.15
SMILES Code : O=[N+]([O-])C1C=C(F)C(CCO)=CC=1

Safety of [ 1221119-68-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362

Application In Synthesis of [ 1221119-68-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1221119-68-1 ]

[ 1221119-68-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 337529-74-5 ]
  • [ 1221119-68-1 ]
YieldReaction ConditionsOperation in experiment
77% With methanol; sodium tetrahydroborate; at 0 - 70℃; for 16h; Step 3: To a stirred solution of <strong>[337529-74-5]methyl 2-(2-fluoro-4-nitrophenyl)acetate</strong> (3.0g, 14.0 mmol, 1 .0 eq) in methanol (30 mL) was added NaBH4 (2.08g, 36.3mmol, 4.0eg) at 0C and stirred at 70 C for 16h, then the methanol was evaporated and the residue was diluted with water (30 mL), the pH adjusted to being neutral with 2N HCI and the mixture extracted with EtOAc (50 mL x 3). The organic layer was separated, washed with brine, dried over Na2S04 and the solvent evaporated to yield 2-(2-fluoro-4-nitrophenyl)ethanol (2.0 g, 77%) as a viscous oil (TLC system: EtOAc/PE (3:7), Rf: 0.3).
 

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