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Chemical Structure| 1221237-81-5 Chemical Structure| 1221237-81-5

Structure of 1221237-81-5

Chemical Structure| 1221237-81-5

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Product Details of [ 1221237-81-5 ]

CAS No. :1221237-81-5
Formula : C19H14BrN
M.W : 336.23
SMILES Code : CC1=CC2=C(N(C3=CC=CC=C3)C4=C2C=C(Br)C=C4)C=C1

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Application In Synthesis of [ 1221237-81-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1221237-81-5 ]

[ 1221237-81-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 57103-20-5 ]
  • [ 74-88-4 ]
  • [ 1221237-81-5 ]
YieldReaction ConditionsOperation in experiment
71% Preparation of Structural Formula 1C; The Structural Formula 1B (18.9 g, 47.1 mmol)) was dissolved in 200 ml of tetrahydrofurane anhydride, and cooled to -78ºC, and 2.5 M n-butyl lithium (18.8 ml, 47.1 mmol) was slowly added thereto, and agitated for 1 hour. After iodomethane (3.2 ml, 51.8 mmol) was added to the reaction solution, the temperature was slowly increased to normal temperature, it was agitated for 2 hours, and the ammonium chloride aqueous solution was added thereto to finish the reaction, thereby extracting the organic layer. The reaction solution was concentrated, and recrystallized with petroleum ether to obtain the Structural Formula 1C (11.2 g, yield 71 %). MS: [M+H]-= 337
 

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