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Chemical Structure| 1221726-34-6 Chemical Structure| 1221726-34-6

Structure of 1221726-34-6

Chemical Structure| 1221726-34-6

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Product Details of [ 1221726-34-6 ]

CAS No. :1221726-34-6
Formula : C9H13ClN4O2
M.W : 244.68
SMILES Code : O=[N+](C1=CC=C(N2CCNCC2)C=N1)[O-].[H]Cl
MDL No. :MFCD13368249

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Application In Synthesis of [ 1221726-34-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1221726-34-6 ]

[ 1221726-34-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 110-85-0 ]
  • [ 52092-47-4 ]
  • [ 1221726-34-6 ]
YieldReaction ConditionsOperation in experiment
82.3% In butan-1-ol; at 95℃; for 24h;Inert atmosphere; A nitrogen-flushed, suitably equipped 22 L 4-neck round bottom flask is charged with 1392 g (8.78 mol, 1.0 eq.) of <strong>[52092-47-4]5-chloro-2-nitropyridine</strong> (A2d), 1512 g (17.56 mol, 2.0 eq.) of piperazine (A2c) and 11,340 g (14,000 mL) of n-butanol.The resulting suspension is stirred and heated to 95° C.This temperature is maintained for at least 24 h or until the remaining starting material, A2d, is ?2percent (area normalization) as determined by HPLC analysis.The resulting slurry is cooled to 25° C. over 1 h.The solids are filtered through a polypropylene filter pad.The filter cake is washed twice with a total of 2267 g (2*1300 mL) of isopropyl acetate.The solids are dried at 60° C. for 16 h, to afford 1769 g (82.3percent, uncorrected) of A2b as a yellow, crystalline solid, mp>230° C. (dec.).
 

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