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CAS No. : | 1244058-73-8 | MDL No. : | MFCD16987860 |
Formula : | C6H4ClN3S | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 185.63 | Pubchem ID : | - |
Synonyms : |
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Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
76% | With hydrogenchloride; In 1,4-dioxane; water; at 110℃; for 48h; | 4,6-Dichloropyridin-3-amine (int-57) (1.5 g, 9.3 mmol) and potassium thiocyanate (2.69 g, 27.8 mmol) were dissolved in dioxane (30 mL) and concentrated aq. HC1 (0.1 mL) was added. The solution was stirred at 1 1() C for 2 days. Then, the solvent was removed under reduced pressure, and the residue was purified by column chromatography on silica gel using a mixture of petroleum ether and EtOAc (1:1) as eluent to give 6-chlorothiazolo[4,5-cjpyridin-2-arnine (int?58) (1.3 g, 76percent yield) as a yellow solid. MS (ESI): mz 185.9 [M+H]. |