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Chemical Structure| 1248477-79-3 Chemical Structure| 1248477-79-3

Structure of 1248477-79-3

Chemical Structure| 1248477-79-3

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Product Details of [ 1248477-79-3 ]

CAS No. :1248477-79-3
Formula : C7H14N4O
M.W : 170.21
SMILES Code : [N-]=[N+]=NCCCN1CCOCC1
MDL No. :MFCD14658124

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Application In Synthesis of [ 1248477-79-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1248477-79-3 ]

[ 1248477-79-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 57616-74-7 ]
  • [ 1248477-79-3 ]
YieldReaction ConditionsOperation in experiment
With sodium azide; potassium carbonate; In water; at 75℃; General procedure: To a solution of corresponding reactant 6a-6j (4 mmol) in water (30 mL) was added K2CO3(1.656 g, 12 mmol) and sodium azide (0.390 g, 6 mmol). The reaction mixture was stirred at 75 C for10 h, then cooled to room temperature and extracted by dichloromethane (15 mL x 3). The organiclayer was partitioned, combined, washed with bine (15 mL), dried over magnesium sulfate andconcentrated to afford crude product 7a-7j. The crude residue 7a-7j was then dissolved in a mixturesolvent of t-BuOH/H2O (v:v = 1:1, 15 mL). Compound 5 (0.836 g, 2 mmol), sodium ascorbate (119 mg,0.6 mmol), and CuSO4*5H2O (5 mg, 0.02 mmol) were added into the mixture. The reaction mixturewas stirring at room temperature under N2 protection overnight. Then water (200 mL) was addedand the mixture was extracted by dichloromethane (15 mL x 3). The organic layer was partitioned, combined, washed with bine (15 mL), dried over magnesium sulfate and concentrated. The residuewas purified by column chromatography (20:1 dichloromethane/methanol) to afford the products8a-8j.
 

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