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Chemical Structure| 1253592-06-1 Chemical Structure| 1253592-06-1

Structure of 1253592-06-1

Chemical Structure| 1253592-06-1

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Product Details of [ 1253592-06-1 ]

CAS No. :1253592-06-1
Formula : C10H12BrN
M.W : 226.11
SMILES Code : CN1CCCC2=C1C=C(Br)C=C2
MDL No. :MFCD24387250

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Application In Synthesis of [ 1253592-06-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1253592-06-1 ]

[ 1253592-06-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 50-00-0 ]
  • [ 114744-51-3 ]
  • [ 1253592-06-1 ]
YieldReaction ConditionsOperation in experiment
67% Example 68: 1,1,1,3,3,3-Hexafluoropropan-2-yl 1-((1-methyl-1,2,3,4-tetrahydroquinolin-7- yl)methyl)-1,8-diazaspiro[4.5]decane-8-carboxylate Step 1: Preparation of 7-bromo-1-methyl-1,2,3,4-tetrahydroquinoline A flask was charged with <strong>[114744-51-3]7-bromo-1,2,3,4-tetrahydroquinoline</strong> (2.50 g, 11.8 mmol, 1.00 equiv), paraformaldehyde (1.10 g, 35.4 mmol, 3.00 equiv), and DCE (30 mL). The resulting solution was stirred for 1 h at rt. NaBH(OAc)3 (7.50 g, 35.4 mmol, 3.00 equiv) was added, and the solution was stirred overnight at 40 ^C. Water (20 mL) was added, and the mixture was extracted with DCM (3 x 30 mL); the organic layers were combined, washed with brine (3 x 10 mL), dried over anhydrous Na2SO4, filtered, and concentrated. The residue was purified on a silica gel column (1:5 EtOAc/petroleum ether) to provide (67% yield) of 7-bromo-1-methyl-1,2,3,4- tetrahydroquinoline as a yellow oil. LCMS (ESI, m/z): 226 [M+H]+.
 

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