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Chemical Structure| 1254309-85-7 Chemical Structure| 1254309-85-7

Structure of 1254309-85-7

Chemical Structure| 1254309-85-7

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Product Details of [ 1254309-85-7 ]

CAS No. :1254309-85-7
Formula : C11H8BrF3N2O2
M.W : 337.09
SMILES Code : O=C(C1=CN2C=C(C(F)(F)F)C=C(Br)C2=N1)OCC

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Application In Synthesis of [ 1254309-85-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1254309-85-7 ]

[ 1254309-85-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 70-23-5 ]
  • [ 79456-30-7 ]
  • [ 1254309-85-7 ]
YieldReaction ConditionsOperation in experiment
In 1,2-dimethoxyethane; at 20℃; for 18h;Reflux; To a solution of <strong>[79456-30-7]2-amino-3-bromo-5-(trifluoromethyl)pyridine</strong> (10.0 g, 41.5 mmol) in 1,2 dimethoxyethane (300 rnL) at room temperature was added ethyl bromopyruvate (9.889 g, 45.64 mmol) dropwise. The reaction mixture was heated to reflux for 18 h. The 1,2- dimethoxyethane was removed under reduced pressure and the residual solid was recrystalized from 1-chlorobutane. The solid was isolated by filtration and dried to afford an off-white solid, 8-bromo-6-(trifluoromethyl)imidazo[l,2-alpha]pyridine-2-carboxylic acid, ethyl ester (11.044 g).The solid obtained above was dissolved in tetrahydrofuran (150 mL) and a solution of LiOH (2.353 g, 98.29 mmol) in water (100 mL) was added. The reaction mixture was stirred at room temperature for 4 h. The tetrahydrofuran was removed under reduced pressure to provide an aqueous solution which was cooled to 5 0C. Dilute HCl was added dropwise until a pH < 5.0 was achieved. After several minutes a solid began to precipitate from the solution. The solid was collected by filtration, washed once with water (50 mL), and dried in a vacuum oven for 18 h at 80 0C to afford 8.632 g of the title compound as a solid. 1H NMR (dmso-d6) delta 13.17 (br s, IH), 9.31 (s, IH), 8.69 (s, IH), 8.03 (s, IH).
 

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