630-580-1088 sales@ambeed.com
Structure Search

List Search MOL Search Structure Search

0
Chemistry
Asymmetric Synthesis >>Chiral Building BlocksChiral Catalysts, Chiral Ligands and Chiral ReagentsChiral Resolution ReagentsBoronic acids/esters >>Aliphatic BoronsAromatic BoronsOther BoronsOxaborolesCatalysis Chemistry >>Achiral Crown LigandsC-H ActivationCarbon-Donor LigandsChiral Carbon LigandsChiral Crown LigandsChiral Olefin LigandsCross-CouplingCross-Coupling Using Transition Metal CatalystsDACH or Trost LigandsChemical Biology >>Conjugation Chemistry
GlycoscienceLinkers and CrosslinkersNucleic Acid ChemistryPEGylationPeptide ChemistryPhotolabile Protecting GroupHeterocyclic Building Blocks >>AcridinesAliphatic HeterocyclesAromatic HeterocyclesAzetidinesBenzimidazolesBenzisoxazolesBenzodioxansBenzofuransBenzothiazolesInorganic reagents >>Inorganic reagentOrganic Building Blocks >>Acid AnhydridesAcyl Chlorides
AlcoholsAldehydesAliphatic Chain HydrocarbonsAliphatic Cyclic HydrocarbonsAlkenesAlkylsAlkynesOrganometallic Reagents >>Grignard ReagentsOrganoarsenicOrganobismuthOrganoboronOrganogermaniumOrganolithiumOrganomercuryOrganosiliconOrganotinSpecialty Synthesis >>Enzyme-Mediated SynthesisFluorous SynthesisIonic Liquids
Solid Supported SynthesisStains and Dyes >>Acid DyesAzoic DyesBasic DyesDirect DyesDisperse DyesDye IntermediatesMordant DyesOil DyesOther Stains and DyesSynthetic Reagents >>Acids and BasesC-C Bond FormationC-X Bond Formation (Halogen)C-X Bond Formation (Non-Halogen)Chelation and Complexation CompoundsCondensation AgentsCouplingDehydrating ReagentsFluorination Reagent
Pharmaceutical Intermediates
Analgesics >>BenzhydrocodoneBicifadineCapsaicinCelecoxibDebio-0827DexamethasoneElagolix SodiumEsketamine HydrochlorideIbuprofen sodiumAnesthetics >>CiprofolEsketamine HydrochlorideFospropofol Fospropofol DisodiumLevobupivacaine RemimazolamRemimazolam BesilateRemimazolam besylateRopivacaineAnti-Addiction Agents >>Kakonein
Lofexidine HydrochlorideVarenicline Anti-inflammatory Agents >>ApremilastAsunaprevirATB-346 RelatedBalsalazide BaricitinibBencycloquidium BromideBudesonideCefiderocol Sulfate TosylateCeftaroline Fosamil AcetateAntibacterials >>AFN-1252 RelatedAlatrofloxacin Bedaquiline FumarateBesifloxacin BrilacidinCaspofungin AcetateCefiderocol Sulfate TosylateCefilavancinCeftaroline Fosamil
Anticonvulsants >>BrivaracetamCannabidiolEscitalopram OxalateEslicarbazepine Acetate RelatedFosphenytoinGabapentin EnacarbilJNJ-10234094LacosamideLevetiracetam RelatedAntidementia Agents >>Azeliragon RelatedDavunetideDonepezil HydrochlorideDonepezil RelatedEnsaculinFlorbetaben Flortaucipir F 18Flutemetamol IdalopirdineAntidepressants >>4-Chlorokynurenine
AgomelatineAgomelatine RelatedAllopregnanolone RelatedAmibegronAmitifadineAripiprazole RelatedBasimglurantBefloxatoneAntiemetics >>AprepitantAprepitant RelatedDolasetron RelatedDolasetron Mesylate HydrateFosaprepitant DimeglumineFosaprepitant RelatedOlanzapinePalonosetron RelatedPalonosetron HydrochlorideAntifungals >>Anidulafungin RelatedCabotegravirMore >>
Inhibitors/Agonists
ADC >>ADC AntibodyADC LinkerADC Linker with PayloadADC ToxinAntibody-Drug Conjugates (ADCs)Drug-Linker Conjugates for ADCAngiogenesis >>ALKBcr-AblBTKEGFRFAKFGFRFLT3HER2HIFAnti-infection >>3CLproAntibacterialAntibioticAntifungal
AntiparasiticAntiprotozoalAntiviralArenavirusBVDVApoptosis >>Apoptosis InducerBcl-2Bcl-6BRKc-Mycc-RETC/EBPCARDCaspaseAutophagy >>Atg4ATG4BATTECsAUTACsAutophagyBeclin1
FKBPLC3LRRK2Biochemical Reagent >>Cell Cycle >>AntifolateAPCAurora KinaseBUBCasein KinaseCdc25CDKChkCRISPR/Cas9Cytoskeleton >>ActinArp2/3 ComplexCYTHCytoplasmic dyneinDynaminFAKMore >>
Material Science
Aggregation-Induced Emission >>Other AIE BlocksTetraphenylethylene SeriesCOFs Linkers >>Aldehyde COFs LinkersAlkynyl COFs LinkersAmine COFs LinkersBoric COFs LinkersCyano COFs LinkersMultifunctional COFs linkersOther COFs linkersTriphene seriesElectronic Materials >>Battery MaterialsDye-Sensitized Solar Cell (DSSC) MaterialsElectronic MaterialLiquid Crystal (LC) MaterialsMolecular ConductorsOrganic Light-Emitting Diode (OLED) MaterialsOrganic Solar Cell (OPV) MaterialsOrganic Transistor (OFET) MaterialsPerovskite Solar Cell (PSC) MaterialsMagnetic Materials >>Magnetic Ionic LiquidsMagnetic MaterialMagnetic Metal Complexes
Organic Radicals Material Chemical Compounds >>Ligands for Functional Metal ComplexesLiquid Crystal (LC) Building BlocksPhthalocyanine Building BlocksPolymer and Macromolecule Semiconductor Building BlocksSmall Molecule Semiconductor Building BlocksSolubility Enhancing Reagents Supramolecular Host Materials MOF Ligands >>Carboxylic Acid MOF LigandsCarboxylic Acid Nitrogen-Containing Mixed MOF LigandsNitrogen-Containing MOF LigandsOther MOF ligandsNanomaterials >>Carbon NanomaterialsCeramic MembranesDendrimersGold NanoparticlesIron Oxide NanoparticlesMaterials by ApplicationMesoporous MaterialsMetals and Metal AlloysNano Minerals: NanoclaysOLED Materials >>Dopant
HostHTMOLED IntermediatesOther OLED related materialsOptical Materials >>Coumarin DyesCyanine and Squarylium DyesDCM DyesDipyrromethene DyesFluorescence MaterialsFluorescent ProbesHeat and Pressure Sensitive DyesNear-Infrared (NIR) DyesOrganic Non-Linear Optical (NLO) MaterialsOrganic Pigments >>Organic PigmentOther Materials >>Mateial OtherPolymer Science >>MonomersPolymer AdditivesPolymerization ReagentsPolymersResins
Contact Us
Home Cart 0 Sign in  
Chemistry
Organometallic Reagents
Organoboron
(2,5-Difluoro-1,4-phenylene)diboronic acid
Chemistry
Organometallic Reagents
Organic Building Blocks Boronic acids/esters
Organoboron
Aryls Fluorinated Building Blocks Benzene Compounds Aromatic Borons

[ CAS No. 1256358-83-4 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 1256358-83-4
Chemical Structure| 1256358-83-4
Structure of 1256358-83-4 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

For Research Only 110K+ Compounds Competitive Price 1-2 Day Shipping

Quality Control of [ 1256358-83-4 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 1256358-83-4 ]

SDS Specification
Alternatived Products of [ 1256358-83-4 ]

Product Details of [ 1256358-83-4 ]

CAS No. :1256358-83-4 MDL No. :MFCD17015780
Formula : C6H6B2F2O4 Boiling Point : -
Linear Structure Formula :- InChI Key :CSOLBHLZNAGMMP-UHFFFAOYSA-N
M.W : 201.73 Pubchem ID :53216760
Synonyms :

Calculated chemistry of [ 1256358-83-4 ]

Physicochemical Properties

Num. heavy atoms : 14
Num. arom. heavy atoms : 6
Fraction Csp3 : 0.0
Num. rotatable bonds : 2
Num. H-bond acceptors : 6.0
Num. H-bond donors : 4.0
Molar Refractivity : 46.01
TPSA : 80.92 Ų

Pharmacokinetics

GI absorption : High
BBB permeant : No
P-gp substrate : No
CYP1A2 inhibitor : No
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : Yes
Log Kp (skin permeation) : -7.58 cm/s

Lipophilicity

Log Po/w (iLOGP) : 0.0
Log Po/w (XLOGP3) : -0.07
Log Po/w (WLOGP) : -1.84
Log Po/w (MLOGP) : -0.59
Log Po/w (SILICOS-IT) : -2.33
Consensus Log Po/w : -0.96

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 0.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -1.23
Solubility : 11.8 mg/ml ; 0.0586 mol/l
Class : Very soluble
Log S (Ali) : -1.18
Solubility : 13.4 mg/ml ; 0.0664 mol/l
Class : Very soluble
Log S (SILICOS-IT) : -0.74
Solubility : 36.5 mg/ml ; 0.181 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 1.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 2.42

Safety of [ 1256358-83-4 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P233-P260-P261-P264-P270-P271-P280-P301+P312-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P330-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1256358-83-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1256358-83-4 ]

[ 1256358-83-4 ] Synthesis Path-Downstream   1~9

  • 1
  • [ 327-51-5 ]
  • [ 1256358-83-4 ]
Reference： [1]Crystal Growth and Design,2012,vol. 12,p. 3720 - 3734
  • 2
  • [ 1256358-83-4 ]
  • (1S,2R,5S,6R)-3,3,7,7-Tetramethyl-1,2,3,5,6,7-hexahydro-s-indacene-1,2,5,6-tetraol [ No CAS ]
  • [ 71-43-2 ]
  • C44H40B4F4O8*C6H6 [ No CAS ]
Reference： [1]Angewandte Chemie - International Edition,2013,vol. 52,p. 11045 - 11048
    Angewandte Chemie,2013,vol. 125,p. 11251 - 11254,4
  • 3
  • [ 1256358-83-4 ]
  • [ 108-88-3 ]
  • (1S,2R,5S,6R)-3,3,7,7-Tetramethyl-1,2,3,5,6,7-hexahydro-s-indacene-1,2,5,6-tetraol [ No CAS ]
  • C44H40B4F4O8*C7H8 [ No CAS ]
Reference： [1]Angewandte Chemie - International Edition,2013,vol. 52,p. 11045 - 11048
    Angewandte Chemie,2013,vol. 125,p. 11251 - 11254,4
  • 4
  • [ 1256358-83-4 ]
  • [ 108-88-3 ]
  • (1S,2R,5S,6R)-3,3,7,7-Tetramethyl-1,2,3,5,6,7-hexahydro-s-indacene-1,2,5,6-tetraol [ No CAS ]
  • [ 275-51-4 ]
  • C44H40B4F4O8*0.6C7H8*0.4C10H8 [ No CAS ]
Reference： [1]Angewandte Chemie - International Edition,2013,vol. 52,p. 11045 - 11048
    Angewandte Chemie,2013,vol. 125,p. 11251 - 11254,4
  • 5
  • [ 1256358-83-4 ]
  • (1S,2R,5S,6R)-3,3,7,7-Tetramethyl-1,2,3,5,6,7-hexahydro-s-indacene-1,2,5,6-tetraol [ No CAS ]
  • [ 275-51-4 ]
  • C44H40B4F4O8*0.95C10H8 [ No CAS ]
Reference： [1]Angewandte Chemie - International Edition,2013,vol. 52,p. 11045 - 11048
    Angewandte Chemie,2013,vol. 125,p. 11251 - 11254,4
  • 6
  • [ 91-20-3 ]
  • [ 1256358-83-4 ]
  • (1S,2R,5S,6R)-3,3,7,7-Tetramethyl-1,2,3,5,6,7-hexahydro-s-indacene-1,2,5,6-tetraol [ No CAS ]
  • C44H40B4F4O8*0.95C10H8 [ No CAS ]
Reference： [1]Angewandte Chemie - International Edition,2013,vol. 52,p. 11045 - 11048
    Angewandte Chemie,2013,vol. 125,p. 11251 - 11254,4
  • 7
  • [ 1256358-83-4 ]
  • (1S,2R,5S,6R)-3,3,7,7-Tetramethyl-1,2,3,5,6,7-hexahydro-s-indacene-1,2,5,6-tetraol [ No CAS ]
  • [ 95-15-8 ]
  • C44H40B4F4O8*0.95C8H6S [ No CAS ]
Reference： [1]Angewandte Chemie - International Edition,2013,vol. 52,p. 11045 - 11048
    Angewandte Chemie,2013,vol. 125,p. 11251 - 11254,4
  • 8
  • [ 5419-55-6 ]
  • [ 327-51-5 ]
  • [ 1256358-83-4 ]
Reference： [1]Chemistry - A European Journal,2018,vol. 24,p. 11438 - 11443
  • 9
  • [ 1256358-83-4 ]
  • C20H11Br3O6 [ No CAS ]
  • C116H32B12Br12F12O24 [ No CAS ]
Reference： [1]Chemistry - A European Journal,2018,vol. 24,p. 11438 - 11443

Tags: 1256358-83-4 synthesis path| 1256358-83-4 SDS| 1256358-83-4 COA| 1256358-83-4 purity| 1256358-83-4 application| 1256358-83-4 NMR| 1256358-83-4 COA| 1256358-83-4 structure

Same Skeleton Products
Related Products
Historical Records

Similar Product of
[ 1256358-83-4 ]

Chemical Structure| N/A

A927070[ N/A ]

(2,5-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)boronic acid

Reason: Derivatives

Related Functional Groups of
[ 1256358-83-4 ]

Fluorinated Building Blocks

Chemical Structure| 193353-34-3

[ 193353-34-3 ]

(2,5-Difluorophenyl)boronic acid

Similarity: 1.00

Chemical Structure| 1993-03-9

[ 1993-03-9 ]

(2-Fluorophenyl)boronic acid

Similarity: 0.97

Chemical Structure| 2377610-01-8

[ 2377610-01-8 ]

(2-Fluoro-1,3-phenylene)diboronic acid

Similarity: 0.94

Chemical Structure| 144025-03-6

[ 144025-03-6 ]

2,4-Difluorophenylboronic acid

Similarity: 0.94

Chemical Structure| 182482-25-3

[ 182482-25-3 ]

2,4,6-Trifluorophenylboronic acid

Similarity: 0.94

Organoboron

Chemical Structure| 193353-34-3

[ 193353-34-3 ]

(2,5-Difluorophenyl)boronic acid

Similarity: 1.00

Chemical Structure| 1993-03-9

[ 1993-03-9 ]

(2-Fluorophenyl)boronic acid

Similarity: 0.97

Chemical Structure| 2377610-01-8

[ 2377610-01-8 ]

(2-Fluoro-1,3-phenylene)diboronic acid

Similarity: 0.94

Chemical Structure| 144025-03-6

[ 144025-03-6 ]

2,4-Difluorophenylboronic acid

Similarity: 0.94

Chemical Structure| 182482-25-3

[ 182482-25-3 ]

2,4,6-Trifluorophenylboronic acid

Similarity: 0.94

Aryls

Chemical Structure| 193353-34-3

[ 193353-34-3 ]

(2,5-Difluorophenyl)boronic acid

Similarity: 1.00

Chemical Structure| 1993-03-9

[ 1993-03-9 ]

(2-Fluorophenyl)boronic acid

Similarity: 0.97

Chemical Structure| 2377610-01-8

[ 2377610-01-8 ]

(2-Fluoro-1,3-phenylene)diboronic acid

Similarity: 0.94

Chemical Structure| 144025-03-6

[ 144025-03-6 ]

2,4-Difluorophenylboronic acid

Similarity: 0.94

Chemical Structure| 182482-25-3

[ 182482-25-3 ]

2,4,6-Trifluorophenylboronic acid

Similarity: 0.94