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Structure of 1260220-43-6

Chemical Structure| 1260220-43-6

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Product Details of [ 1260220-43-6 ]

CAS No. :1260220-43-6
Formula : C15H22N2O3
M.W : 278.35
SMILES Code : O=C(N1C[C@H](C2=CC=C(N)C=C2)OCC1)OC(C)(C)C
MDL No. :MFCD23703253
InChI Key :RYLFTAZSKDUPAA-CYBMUJFWSA-N
Pubchem ID :66705988

Safety of [ 1260220-43-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 1260220-43-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1260220-43-6 ]

[ 1260220-43-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 37718-11-9 ]
  • [ 1260220-43-6 ]
  • [ 1576240-44-2 ]
YieldReaction ConditionsOperation in experiment
8.8 g With 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; at 20℃; for 72h; In a 100 mL round-bottomed flask, (S)-tert-butyl 2-(4-aminophenyl)morpholine-4-carboxylate (12.5 g, 44.9 mmol, Eq: 1.00), lH-<strong>[37718-11-9]pyrazole-4-carboxylic acid</strong> (5.03 g, 44.9 mmol, Eq: 1.00), HBTU (25.5 g, 67.4 mmol, Eq: 1.5) and N-methylmorpholine (13.6 g, 14.8 ml, 135 mmol, Eq: 3) were combined with DMF (1250 ml) to give a light yellow solution. The reaction mixture was stirred at room temperature for 3 days. The reaction mixture was poured into 200 mL H20, extracted with EtOAc (2 x) and washed with brine. The combined organic layers were dried over MgS04 and concentrated in vacuo. The crude material was purified by silica gel column chromatography leading to 8.8 g off-white solid. MS (ISP): 373.2 ([M+H]+).
 

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