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Chemical Structure| 1260794-26-0 Chemical Structure| 1260794-26-0

Structure of 1260794-26-0

Chemical Structure| 1260794-26-0

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Product Details of [ 1260794-26-0 ]

CAS No. :1260794-26-0
Formula : C10H6ClNO2
M.W : 207.61
SMILES Code : O=C(C1=CN=C(Cl)C2=C1C=CC=C2)O
MDL No. :MFCD15526637

Safety of [ 1260794-26-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501

Application In Synthesis of [ 1260794-26-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1260794-26-0 ]

[ 1260794-26-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 66728-98-1 ]
  • [ 124-38-9 ]
  • [ 1260794-26-0 ]
YieldReaction ConditionsOperation in experiment
75% 1.40 g (5.77 mmol) of 36 in dry THF (30 ml) was cooled to -80 C under argon then and solution of t-BuLi (12.70 mmol, 7.47 ml of 1.7 M solution in hexane) was added dropwise via syringe and stirred at -80 C for 20 min. The reaction mixture was poured onto crushed dry ice under nitrogen, 50 ml of water was added and solution was made basic using 1 M NaOH solution. The aqueous solution was washed with EtOAc (3× 50 ml) and acidified with concd HCl (a white precipitate was immediately formed). The precipitate was filtered off and dried under vacuum to yield 900 mg of acid 37 (yield 75%). 1H NMR (DMSO-d6): delta 13.68 (s, 1H); 8.97 (d, 1H, J = 8.55 Hz); 8.86 (s, 1H); 8.41 (d, 1H, J = 8,30 Hz); 8.05-8.01 (m, 1H); 7.92-7.89 (m, 1H). 13C NMR (DMSO-d6): delta 167.3; 155.0; 145.2; 135.6; 133.6; 129.9; 126.8; 126.3; 126.0; 122.2.
 

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