630-580-1088 sales@ambeed.com
Structure Search

List Search MOL Search Structure Search

0
Chemistry
Asymmetric Synthesis >>Chiral Building BlocksChiral Catalysts, Chiral Ligands and Chiral ReagentsChiral Resolution ReagentsBoronic acids/esters >>Aliphatic BoronsAromatic BoronsOther BoronsOxaborolesCatalysis Chemistry >>Achiral Crown LigandsC-H ActivationCarbon-Donor LigandsChiral Carbon LigandsChiral Crown LigandsChiral Olefin LigandsCross-CouplingCross-Coupling Using Transition Metal CatalystsDACH or Trost LigandsChemical Biology >>Conjugation Chemistry
GlycoscienceLinkers and CrosslinkersNucleic Acid ChemistryPEGylationPeptide ChemistryPhotolabile Protecting GroupHeterocyclic Building Blocks >>AcridinesAliphatic HeterocyclesAromatic HeterocyclesAzetidinesBenzimidazolesBenzisoxazolesBenzodioxansBenzofuransBenzothiazolesInorganic reagents >>Inorganic reagentOrganic Building Blocks >>Acid AnhydridesAcyl Chlorides
AlcoholsAldehydesAliphatic Chain HydrocarbonsAliphatic Cyclic HydrocarbonsAlkenesAlkylsAlkynesOrganometallic Reagents >>Grignard ReagentsOrganoarsenicOrganobismuthOrganoboronOrganogermaniumOrganolithiumOrganomercuryOrganosiliconOrganotinSpecialty Synthesis >>Enzyme-Mediated SynthesisFluorous SynthesisIonic Liquids
Solid Supported SynthesisStains and Dyes >>Acid DyesAzoic DyesBasic DyesDirect DyesDisperse DyesDye IntermediatesMordant DyesOil DyesOther Stains and DyesSynthetic Reagents >>Acids and BasesC-C Bond FormationC-X Bond Formation (Halogen)C-X Bond Formation (Non-Halogen)Chelation and Complexation CompoundsCondensation AgentsCouplingDehydrating ReagentsFluorination Reagent
Pharmaceutical Intermediates
Analgesics >>BenzhydrocodoneBicifadineCapsaicinCelecoxibDebio-0827DexamethasoneElagolix SodiumEsketamine HydrochlorideIbuprofen sodiumAnesthetics >>CiprofolEsketamine HydrochlorideFospropofol Fospropofol DisodiumLevobupivacaine RemimazolamRemimazolam BesilateRemimazolam besylateRopivacaineAnti-Addiction Agents >>Kakonein
Lofexidine HydrochlorideVarenicline Anti-inflammatory Agents >>ApremilastAsunaprevirATB-346 RelatedBalsalazide BaricitinibBencycloquidium BromideBudesonideCefiderocol Sulfate TosylateCeftaroline Fosamil AcetateAntibacterials >>AFN-1252 RelatedAlatrofloxacin Bedaquiline FumarateBesifloxacin BrilacidinCaspofungin AcetateCefiderocol Sulfate TosylateCefilavancinCeftaroline Fosamil
Anticonvulsants >>BrivaracetamCannabidiolEscitalopram OxalateEslicarbazepine Acetate RelatedFosphenytoinGabapentin EnacarbilJNJ-10234094LacosamideLevetiracetam RelatedAntidementia Agents >>Azeliragon RelatedDavunetideDonepezil HydrochlorideDonepezil RelatedEnsaculinFlorbetaben Flortaucipir F 18Flutemetamol IdalopirdineAntidepressants >>4-Chlorokynurenine
AgomelatineAgomelatine RelatedAllopregnanolone RelatedAmibegronAmitifadineAripiprazole RelatedBasimglurantBefloxatoneAntiemetics >>AprepitantAprepitant RelatedDolasetron RelatedDolasetron Mesylate HydrateFosaprepitant DimeglumineFosaprepitant RelatedOlanzapinePalonosetron RelatedPalonosetron HydrochlorideAntifungals >>Anidulafungin RelatedCabotegravirMore >>
Inhibitors/Agonists
ADC >>ADC AntibodyADC LinkerADC Linker with PayloadADC ToxinAntibody-Drug Conjugates (ADCs)Drug-Linker Conjugates for ADCAngiogenesis >>ALKBcr-AblBTKEGFRFAKFGFRFLT3HER2HIFAnti-infection >>3CLproAntibacterialAntibioticAntifungal
AntiparasiticAntiprotozoalAntiviralArenavirusBVDVApoptosis >>Apoptosis InducerBcl-2Bcl-6BRKc-Mycc-RETC/EBPCARDCaspaseAutophagy >>Atg4ATG4BATTECsAUTACsAutophagyBeclin1
FKBPLC3LRRK2Biochemical Reagent >>Cell Cycle >>AntifolateAPCAurora KinaseBUBCasein KinaseCdc25CDKChkCRISPR/Cas9Cytoskeleton >>ActinArp2/3 ComplexCYTHCytoplasmic dyneinDynaminFAKMore >>
Material Science
Aggregation-Induced Emission >>Other AIE BlocksTetraphenylethylene SeriesCOFs Linkers >>Aldehyde COFs LinkersAlkynyl COFs LinkersAmine COFs LinkersBoric COFs LinkersCyano COFs LinkersMultifunctional COFs linkersOther COFs linkersTriphene seriesElectronic Materials >>Battery MaterialsDye-Sensitized Solar Cell (DSSC) MaterialsElectronic MaterialLiquid Crystal (LC) MaterialsMolecular ConductorsOrganic Light-Emitting Diode (OLED) MaterialsOrganic Solar Cell (OPV) MaterialsOrganic Transistor (OFET) MaterialsPerovskite Solar Cell (PSC) MaterialsMagnetic Materials >>Magnetic Ionic LiquidsMagnetic MaterialMagnetic Metal Complexes
Organic Radicals Material Chemical Compounds >>Ligands for Functional Metal ComplexesLiquid Crystal (LC) Building BlocksPhthalocyanine Building BlocksPolymer and Macromolecule Semiconductor Building BlocksSmall Molecule Semiconductor Building BlocksSolubility Enhancing Reagents Supramolecular Host Materials MOF Ligands >>Carboxylic Acid MOF LigandsCarboxylic Acid Nitrogen-Containing Mixed MOF LigandsNitrogen-Containing MOF LigandsOther MOF ligandsNanomaterials >>Carbon NanomaterialsCeramic MembranesDendrimersGold NanoparticlesIron Oxide NanoparticlesMaterials by ApplicationMesoporous MaterialsMetals and Metal AlloysNano Minerals: NanoclaysOLED Materials >>Dopant
HostHTMOLED IntermediatesOther OLED related materialsOptical Materials >>Coumarin DyesCyanine and Squarylium DyesDCM DyesDipyrromethene DyesFluorescence MaterialsFluorescent ProbesHeat and Pressure Sensitive DyesNear-Infrared (NIR) DyesOrganic Non-Linear Optical (NLO) MaterialsOrganic Pigments >>Organic PigmentOther Materials >>Mateial OtherPolymer Science >>MonomersPolymer AdditivesPolymerization ReagentsPolymersResins
Contact Us
Home Cart 0 Sign in  
Chemistry
Heterocyclic Building Blocks
Pyrazines
3-Bromoimidazo[1,2-b]pyridazin-6-ylamine
Chemistry
Heterocyclic Building Blocks
Organic Building Blocks
Pyrazines
Imidazoles Pyridazines Amines Bromides Other Aromatic Heterocycles

[ CAS No. 1260850-70-1 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 1260850-70-1
Chemical Structure| 1260850-70-1
Structure of 1260850-70-1 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

For Research Only 110K+ Compounds Competitive Price 1-2 Day Shipping

Quality Control of [ 1260850-70-1 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 1260850-70-1 ]

SDS Specification
Alternatived Products of [ 1260850-70-1 ]

Product Details of [ 1260850-70-1 ]

CAS No. :1260850-70-1 MDL No. :MFCD11520885
Formula : C6H5BrN4 Boiling Point : -
Linear Structure Formula :- InChI Key :PBRMNGMQOGOTHS-UHFFFAOYSA-N
M.W : 213.04 Pubchem ID :56763822
Synonyms :

Calculated chemistry of [ 1260850-70-1 ]

Physicochemical Properties

Num. heavy atoms : 11
Num. arom. heavy atoms : 9
Fraction Csp3 : 0.0
Num. rotatable bonds : 0
Num. H-bond acceptors : 2.0
Num. H-bond donors : 1.0
Molar Refractivity : 45.09
TPSA : 56.21 Ų

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : Yes
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -6.89 cm/s

Lipophilicity

Log Po/w (iLOGP) : 1.33
Log Po/w (XLOGP3) : 1.0
Log Po/w (WLOGP) : 1.08
Log Po/w (MLOGP) : 1.18
Log Po/w (SILICOS-IT) : 0.45
Consensus Log Po/w : 1.01

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 0.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -2.4
Solubility : 0.855 mg/ml ; 0.00402 mol/l
Class : Soluble
Log S (Ali) : -1.77
Solubility : 3.62 mg/ml ; 0.017 mol/l
Class : Very soluble
Log S (SILICOS-IT) : -2.21
Solubility : 1.3 mg/ml ; 0.00612 mol/l
Class : Soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 2.33

Safety of [ 1260850-70-1 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1260850-70-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1260850-70-1 ]

[ 1260850-70-1 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1260850-70-1 ]
  • [ 1993-03-9 ]
  • [ 1431537-90-4 ]
Reference： [1]Patent: WO2013/59589,2013,A1
  • 2
  • [ 1260850-70-1 ]
  • [ 1993-03-9 ]
  • [ 1431538-24-7 ]
YieldReaction ConditionsOperation in experiment
55% With tetrakis(triphenylphosphine) palladium(0); In 1,4-dioxane; ethanol; water; at 100.0℃; for 4.0h; 3-bromoimidazo[l,2-b]pyridazin-6-amine (1.8 g, 7.0 mmol), 2-fluorophenylboronic acid (1.33 g,7.0 mmol), Cs2C03 (4.57 g, 14.0 mmol) and Pd[PPh3]4 (0.4 g,0.35 mmol) were dissolved in a mixture solvent (dioxane:water:ethanol = 4: 1 : 10 drops). The reaction was stirred at 100 C for about 4 h. The mixture was purified on a silica gel column to give 3- (2-fluorophenyl)imidazo[l,2-b]pyridazin-6-amine (1.05 g,55%). MS (ESI) calcd for
Reference： [1]Patent: WO2013/59589,2013,A1 .Location in patent: Page/Page column 82

Tags: 1260850-70-1 synthesis path| 1260850-70-1 SDS| 1260850-70-1 COA| 1260850-70-1 purity| 1260850-70-1 application| 1260850-70-1 NMR| 1260850-70-1 COA| 1260850-70-1 structure

Same Skeleton Products
Related Products
Historical Records

Related Functional Groups of
[ 1260850-70-1 ]

Bromides

Chemical Structure| 18087-73-5

[ 18087-73-5 ]

3-Bromoimidazo[1,2-b]pyridazine

Similarity: 0.96

Chemical Structure| 13526-66-4

[ 13526-66-4 ]

3-Bromo-6-chloroimidazo[1,2-b]pyridazine

Similarity: 0.85

Chemical Structure| 1012343-72-4

[ 1012343-72-4 ]

4-(3-Bromoimidazo[1,2-b]pyridazin-6-yl)morpholine

Similarity: 0.85

Chemical Structure| 1368313-23-8

[ 1368313-23-8 ]

3-Bromo-2-methylimidazo[1,2-b]pyridazine

Similarity: 0.84

Chemical Structure| 18112-31-7

[ 18112-31-7 ]

3-Bromo-6-chloro-2-methylimidazo[1,2-b]pyridazine

Similarity: 0.76

Amines

Chemical Structure| 6653-96-9

[ 6653-96-9 ]

Imidazo[1,2-b]pyridazin-6-amine

Similarity: 0.82

Chemical Structure| 154704-35-5

[ 154704-35-5 ]

2-Methylimidazo[1,2-b]pyridazin-6-amine

Similarity: 0.74

Chemical Structure| 166176-46-1

[ 166176-46-1 ]

Imidazo[1,2-b]pyridazin-3-amine

Similarity: 0.69

Chemical Structure| 1010120-55-4

[ 1010120-55-4 ]

5-Bromo[1,2,4]triazolo[1,5-a]pyridin-2-amine

Similarity: 0.64

Chemical Structure| 1161847-36-4

[ 1161847-36-4 ]

6-Chloroimidazo[1,2-b]pyridazin-8-amine

Similarity: 0.63

Related Parent Nucleus of
[ 1260850-70-1 ]

Other Aromatic Heterocycles

Chemical Structure| 18087-73-5

[ 18087-73-5 ]

3-Bromoimidazo[1,2-b]pyridazine

Similarity: 0.96

Chemical Structure| 13526-66-4

[ 13526-66-4 ]

3-Bromo-6-chloroimidazo[1,2-b]pyridazine

Similarity: 0.85

Chemical Structure| 1012343-72-4

[ 1012343-72-4 ]

4-(3-Bromoimidazo[1,2-b]pyridazin-6-yl)morpholine

Similarity: 0.85

Chemical Structure| 1368313-23-8

[ 1368313-23-8 ]

3-Bromo-2-methylimidazo[1,2-b]pyridazine

Similarity: 0.84

Chemical Structure| 6653-96-9

[ 6653-96-9 ]

Imidazo[1,2-b]pyridazin-6-amine

Similarity: 0.82