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Chemical Structure| 1261506-02-8 Chemical Structure| 1261506-02-8

Structure of 1261506-02-8

Chemical Structure| 1261506-02-8

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Product Details of [ 1261506-02-8 ]

CAS No. :1261506-02-8
Formula : C14H10F3NO3
M.W : 297.23
SMILES Code : FC(F)(F)OC1=CC=C(C2=CC=C(C)C([N+]([O-])=O)=C2)C=C1

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Application In Synthesis of [ 1261506-02-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1261506-02-8 ]

[ 1261506-02-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 407-14-7 ]
  • [ 80500-27-2 ]
  • [ 1261506-02-8 ]
YieldReaction ConditionsOperation in experiment
75% With tetrabutylammomium bromide; palladium diacetate; sodium carbonate; In water; at 150℃;Microwave irradiation; Sealed vessel; General procedure: Method A. A solution of Pd(OAc)2 (25.2 mg, 0.112 mmol) and triphenylphosphine (147 mg, 0.560 mmol) in absolute ethanol (4 mL) and anhydrous toluene (4 mL) was stirred at RT under nitrogen for 10 min. After that period, commercially available 5-chloro-2-nitrotoluene 4 (646 mg, 3.76 mmol), 4 mL of 2M aqueous Na2CO3, and the appropriate boronic acid R1B(OH)2 (6.03 mmol) were sequentially added. The resulting mixture was heated at 100 C in a sealed vial under nitrogen overnight. After being cooled to RT, the mixture was diluted with water and extracted with EtOAc. The combined organic phase were dried and concentrated. The crude product was purified by flash chromatography over silica gel column using n-Hex/EtOAc or CHCl3/MeOH mixtures as the eluent.
 

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