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Chemical Structure| 1268390-32-4 Chemical Structure| 1268390-32-4

Structure of 1268390-32-4

Chemical Structure| 1268390-32-4

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Product Details of [ 1268390-32-4 ]

CAS No. :1268390-32-4
Formula : C11H15BO3
M.W : 206.05
SMILES Code : OB1OCC2=CC=C(C=C12)OCCCC

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Application In Synthesis of [ 1268390-32-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1268390-32-4 ]

[ 1268390-32-4 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 109-65-9 ]
  • [ 1196473-37-6 ]
  • [ 1268390-32-4 ]
  • 2
  • [ 109-69-3 ]
  • [ 1196473-37-6 ]
  • [ 1268390-32-4 ]
YieldReaction ConditionsOperation in experiment
22% H181 (lmmol) was dissolved in DMF (lOmL) and cooled to 0°C with ice bath. To this solution under nitrogen were added in sequence sodium hydride (160mg, 4mmol, 4.0eq) and 1-chlorobutane (0.424mL, 4mmol, 4.0eq). The reaction mixture was stirred for 2 days then treated with 1M HC1 (10ml). After extraction with ethyl acetate, the organic layer was washed with water and brine, and dried over anhydrous Na2S04. The residue after rotary evaporation was purified by column chromatography over silica gel to give the title compound (45.7mg, 22percent yield). 1H NMR (300 MHz, DMSO-de): delta 9.09 (s, 1H), 7.29 (d, J = 8.4 Hz, 1H), 7.23 (d, J = 2.4 Hz, 1H), 7.03 (dd, J = 8.1 2.4 Hz, 1H), 4.91 (s, 2H), 3.90 (t, J = 6.6 Hz, 2H), 1.70 (m, 2H), 1.44(m, 2H) and 0.936 (t, J = 7.5 Hz, 3H) ppm. Mp 92-94°C.
 

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