| 95.1% |
With sulfuric acid; ruthenium-carbon composite; hydrogen In water at 90℃; for 8h; |
5.1.2; 5.2.2; 5.3.2
(2) Take 135g of BOC-D-biphenylalanine obtained in step (1) and add it to 650ml of water,Acidify with H2SO4 to PH=1-3, add 2.7g of metal catalyst (Ru/C), and after passing hydrogen for 0.5h,Raise the temperature to 90°C, keep the pressure at 8Mpa and react for 8h,After the reaction is completed, the metal catalyst is filtered off, and the filtrate is concentrated to a small volume. The metal catalyst and the filtrate are distilled and recovered. After the concentration is completed, 100 ml of an alkaline alcohol mixed solution is added to stir and crystallize.Filtration to obtain 129.1g (R)-2-(N-tert-butoxycarbonylamino) biphenylpropanol,The purity was 99.5% and the yield was 95.1%. |
| 71.3% |
With sodium tetrahydroborate; calcium chloride In tetrahydrofuran Reflux; |
8 Steps (4-c) : (R) - 2 - (N-tert-butoxycarbonyl amino) biphenyl propanol
The 1L of the three-port flask by adding tetrahydrofuran 680 ml, CaCl2(0.25mol, 27 . 7g) and NaBH4(0.5mol, 27 . 0g), room temperature stirring 1h, and then flow back 1h, layering, heating the supernatant, adding (R)-N-tert-butoxy carbonyl biphenyl alanine (0.25mol, 85 . 4g), heating to reflux, TLC tracking to the raw point the reaction is complete, reducing pressure and evaporating thf, water beating, a large amount of white solid precipitated, crystallization is the ice-bath is static 3h, filter, vacuum drying, get white solid product (R) - 2 - (N-tert-butoxy-carbonyl amino) biphenyl propanol 58.3g, yield of 71.3%, chemical purity 98.9%, optical purity 98.6% (HPLC). |
| 0.74 g |
Stage #1: (2R)-3-(biphenyl-4-yl)-2-[(tert-butoxycarbonyl)amino]propanoic acid With 4-methyl-morpholine; isobutyl chloroformate In tetrahydrofuran at -15℃; for 0.5h;
Stage #2: With sodium tetrahydroborate; water In tetrahydrofuran at 0℃; for 2h; |
5
To a solution of (R)-3-([1,1'-biphenyl]-4-yl)-2-((tert-butoxycarbonyl)amino)propanoic acid 5 (1 .28 g, corresponding to 2.996 mmol) in tetrahydrofuran (8 mL) at -15 °C was added isobutyl chloroformate (539 mg, 3.749 mmol), followed by N-methylmorpholine (402 mg, 3.937 mmol). A precipitate formed, and after stirring at -15 °C for 30 min, the precipitate was filtered off, followed by washing of the cake with THF. The filtrate was added over 1 h to a solution of sodium borohydride (296 mg, 7.499 mmol) in water (4 mL) at 0 °C. The reaction mixture was stirred at 0 °C for 1 h, then water (15 mL) was added, and the reaction mixture was extracted with ethyl acetate. The combined organic layers were dried over MgS04, filtered and concentrated under vacuum to provide the crude product. Purification by chromatography (silica gel, heptanes/ethyl acetate) gave product 6 (0.74 g, 75% yield over two steps) as a white solid. 1H-NMR (400 MHz, DMSO-d6): δ 1 .32 (s, 9 H), 2.60 (dd, 1 H), 2.86 (dd, 1 H), 3.24-3.31 (m, 1 H), 3.33-3.42 (m, 1 H), 3.52-3.70 (m, 1 H), 4.72 (t, 1 H), 6.56-6.71 (m, 1 H), 7.28 (m, 2 H), 7.30-7.38 (m, 1 H), 7.44 (m, 2 H), 7.56 (m, 2 H), 7.60-7.66 (m, 2 H); MS (ES-API): positive mode 350.3 [M + Na]+. |
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