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Chemical Structure| 128781-80-6 Chemical Structure| 128781-80-6

Structure of Boc-3,5-DiIodo-Tyr-OMe
CAS No.: 128781-80-6

Chemical Structure| 128781-80-6

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Product Details of [ 128781-80-6 ]

CAS No. :128781-80-6
Formula : C15H19I2NO5
M.W : 547.12
SMILES Code : O=C(OC)[C@@H](NC(OC(C)(C)C)=O)CC1=CC(I)=C(O)C(I)=C1
MDL No. :MFCD00237523
InChI Key :LYSAEUWOAILRMR-NSHDSACASA-N
Pubchem ID :14753124

Safety of [ 128781-80-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 128781-80-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 128781-80-6 ]

[ 128781-80-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 128781-80-6 ]
  • [ 175883-62-2 ]
  • [ 1417654-55-7 ]
YieldReaction ConditionsOperation in experiment
73% With copper diacetate; triethylamine; In dichloromethane;Molecular sieve; 96. PREPARATION OF ( J)-METHYL 2-((TERT-BUTOXYCARBONYL)AMINO)-3-(3,5- DIIODO-4-(4-METHOXY-3-METHYLPHENOXY)PHENYL)PROPANOATE (MLAG-090)[00587] A mixture of TEA (204 mu,, 1.462 mmol) and Py ( 118 mu, 1.462 mmol) were added to a stirring solution of MLAG-089 (200 mg, 0.366 mmol), (4-methoxy-3- methylphenyl)boronic acid (91 mg, 0.548 mmol), copper (II) acetate (199 mg, 1.097 mmol), and 4A molecular sieve powder (400 mg), in dry DCM (4 mL). A drying tube was attached and the solution stirred overnight. Additional <strong>[175883-62-2](4-methoxy-3-methylphenyl)boronic acid</strong> (91 mg, 0.548 mmol), copper (II) acetate (199 mg, 1.097 mmol) were added to the reaction mixture and the solution stirred for an additional 5 h. The solution was diluted with ethyl acetate and filtered through celite. The filtrate was concentrated and purified by flash column chromatography (Biotage SP4, 25+M column, eluting with hexanes/ethyl acetate, 0-40% gradient) to give the desired product (179 mg, 73% yield). 1H NMR (400 MHz, CDC13) delta 7.63 (s, 2H), 6.73 - 6.62 (m, 2H), 6.44 (dd, J = 8.8, 3.0 Hz, 1H), 5.09 (d, J = 7.8 Hz, 1H), 4.55 (dd, J = 13.0, 6.5 Hz, 1H), 3.78 (s, 3H), 3.76 (s, 3H), 3.10 (dd, J = 13.7, 5.6 Hz, 1H), 2.93 (dd, J = 13.9, 6.3 Hz, 1H), 2.19 (s, 3H), 1.45 (s, 9H).
 

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