Alternatived Products of [ 1307248-48-1 ]
Product Details of [ 1307248-48-1 ]
CAS No. : | 1307248-48-1 |
MDL No. : | |
Formula : |
C16H20ClF2NO3S
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
379.85
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 1307248-48-1 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 1307248-48-1 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 1307248-48-1 ]
- 1
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[ 1307248-48-1 ]
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[ 1307245-86-8 ]
Reference:
[1]Patent: US2011/118251,2011,A1
[2]Journal of Medicinal Chemistry,2014,vol. 57,p. 3418 - 3429
[3]Organic Process Research and Development,2015,vol. 19,p. 1568 - 1575
[4]Organic Process Research and Development,2015,vol. 19,p. 1568 - 1575
- 2
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[ 1283095-48-6 ]
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[ 1307248-48-1 ]
Reference:
[1]Patent: US2011/118251,2011,A1
[2]Organic Process Research and Development,2015,vol. 19,p. 1568 - 1575
[3]Organic Process Research and Development,2015,vol. 19,p. 1568 - 1575
[4]Organic Process Research and Development,2015,vol. 19,p. 1568 - 1575
- 3
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[ 1307248-45-8 ]
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[ 1307248-48-1 ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 4 steps
1: N-Bromosuccinimide / chlorobenzene / 19 h / 20 - 45 °C / Irradiation
2: sodium hydrogencarbonate; dimethyl sulfoxide / chlorobenzene / 24 h / 20 °C
3: sodium hydrogencarbonate; sodium hypochlorite; potassium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane; chlorobenzene; water / 2 h / 5 - 20 °C
4: (bis-(2-methoxyethyl)amino)sulfur trufluoride / tetrahydrofuran / 24 h / 70 °C |
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Multi-step reaction with 2 steps
1.1: N-Bromosuccinimide / chlorobenzene / 19 h / 20 - 45 °C / Irradiation
1.2: 24 h / 20 °C
1.3: 1 h / 5 - 20 °C / pH 9
2.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / tetrahydrofuran / 24 h / 70 °C |
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Multi-step reaction with 2 steps
1: chromium(VI) oxide; tert.-butylhydroperoxide
2: (bis-(2-methoxyethyl)amino)sulfur trufluoride / toluene / 21 h / 68 - 72 °C / Industrial scale |
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Multi-step reaction with 3 steps
1.1: 2,2'-azobis(isobutyronitrile); 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / dichloromethane / 5 h / 35 - 45 °C / Industrial scale
2.1: sodium hydrogencarbonate / dimethyl sulfoxide / 16 h / 48 - 52 °C / Industrial scale
2.2: 0 - 5 °C / Industrial scale
3.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / toluene / 21 h / 68 - 72 °C / Industrial scale |
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Multi-step reaction with 3 steps
1: 2,2'-azobis(isobutyronitrile); 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / dichloromethane / 5 h / 35 - 45 °C / Industrial scale
2: sodium hydrogencarbonate / dimethyl sulfoxide / 16 h / 48 - 52 °C / Industrial scale
3: (bis-(2-methoxyethyl)amino)sulfur trufluoride / toluene / 21 h / 68 - 72 °C / Industrial scale |
|
Reference:
[1]Current Patent Assignee: ELI LILLY & CO - WO2011/60217, 2011, A1
[2]Toledo, Miguel A.; Pedregal, Concepción; Lafuente, Celia; Diaz, Nuria; Martinez-Grau, Maria Angeles; Jiménez, Alma; Benito, Ana; Torrado, Alicia; Mateos, Carlos; Joshi, Elizabeth M.; Kahl, Steven D.; Rash, Karen S.; Mudra, Daniel R.; Barth, Vanessa N.; Shaw, David B.; McKinzie, David; Witkin, Jeffrey M.; Statnick, Michael A.
[Journal of Medicinal Chemistry, 2014, vol. 57, # 8, p. 3418 - 3429]
[3]Debaillie, Amy C.; Jones, Chauncey D.; Magnus, Nicholas A.; Mateos, Carlos; Torrado, Alicia; Wepsiec, James P.; Tokala, Ramachandar; Raje, Prasad
[Organic Process Research and Development, 2015, vol. 19, # 11, p. 1568 - 1575]
[4]Debaillie, Amy C.; Jones, Chauncey D.; Magnus, Nicholas A.; Mateos, Carlos; Torrado, Alicia; Wepsiec, James P.; Tokala, Ramachandar; Raje, Prasad
[Organic Process Research and Development, 2015, vol. 19, # 11, p. 1568 - 1575]
[5]Debaillie, Amy C.; Jones, Chauncey D.; Magnus, Nicholas A.; Mateos, Carlos; Torrado, Alicia; Wepsiec, James P.; Tokala, Ramachandar; Raje, Prasad
[Organic Process Research and Development, 2015, vol. 19, # 11, p. 1568 - 1575]
- 4
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[ 1307248-48-1 ]
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[ 1307245-87-9 ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 5 steps
1.1: hydrogenchloride / water; isopropyl alcohol / 15 h / 45 °C
2.1: tetrahydrofuran / 1 h / 20 °C
2.2: 15 h / 20 °C
3.1: copper(l) iodide; potassium carbonate; trans-N,N'-dimethylcyclohexane-1,2-diamine / toluene / 15 h / 115 °C / Inert atmosphere
4.1: sodium tetrahydroborate / dichloromethane; methanol / 0.5 h / 0 - 20 °C
5.1: methanol / 0.25 h / 20 °C |
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Reference:
[1]Toledo, Miguel A.; Pedregal, Concepción; Lafuente, Celia; Diaz, Nuria; Martinez-Grau, Maria Angeles; Jiménez, Alma; Benito, Ana; Torrado, Alicia; Mateos, Carlos; Joshi, Elizabeth M.; Kahl, Steven D.; Rash, Karen S.; Mudra, Daniel R.; Barth, Vanessa N.; Shaw, David B.; McKinzie, David; Witkin, Jeffrey M.; Statnick, Michael A.
[Journal of Medicinal Chemistry, 2014, vol. 57, # 8, p. 3418 - 3429]
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