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CAS No. : | 131-48-6 | MDL No. : | MFCD00006620 |
Formula : | C11H19NO9 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 309.27 | Pubchem ID : | - |
Synonyms : |
NANA;Lactaminic acid;NPC-09;Aceneuramic acid;Aceneuramic acid anhydrous;Sialic acid;Acidium aceneuramicum;Acide aceneuramique;Acido aceneuramico;NeuAc;Neu5Ac
|
Chemical Name : | (4S,5R,6R,7S,8R)-5-Acetamido-4,6,7,8,9-pentahydroxy-2-oxononanoic acid |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
95% | In methanol; | Preparation of sialic acid methyl ester, 25 A mixture of 3.0 g of sialic acid 24 and 16.6 g of Dowex W50 (H+) resin in 335 mL methanol was stirred at room temperature for 3 h. The undissolved sialic acid slowly disappeared during the course of reaction. The resulting homogeneous solution was decanted and stored in the refrigerator. Methanol (235 mL) was added to the resin and stirring continued for 2 h at room temperature. The solution was then decanted and the resin was washed with an additional 400 mL methanol. The combined decants were evaporated under vacuum to give 4.1 g of the methyl ester as a white solid (95% yield). TLC: methanol/dichloro-methane (1:3), Rf 0.32, produced brown to black spot (10% H2 SO4, heat). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium hydroxide; nitrogen; | EXAMPLE 7 Synthesis of Sodium Salt of <strong>[131-48-6]N-Acetylneuraminic acid</strong> A small amount of activated carbon was added to an aqueous solution of <strong>[131-48-6]N-acetylneuraminic acid</strong> and, under a flow of nitrogen gas, 1N sodium hydroxide was added to obtain a pH value of pH 7.3 to 7.8. The reacted solution was filtered using a filter of 0.2 mum and the filtrate was freeze-dried, forming a colorless powder of sodium salt of <strong>[131-48-6]N-acetylneuraminic acid</strong>. 1R 3400 cm-, 2937 cm-, 1660 to 1620 cm-1, 1560 cm-1, decomposition point: about 140-185 C., (decomposition with foaming) 1 H-400 MHz (D2 O); 1,807 (dd, H3ax); 2,205 (dd, H3eq); 4,022 (m, H4); 3,901 (t, H5); 3,973 (d, H6); 3,501 (d, H7); 3,747 (m, H8); 3,598 (dd, H9'); 3,831 (dd, H9); 2,041 (s, Ac-5). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium dithionite; acetic acid; 2-hydroxyethanethiol; at 50.0℃; for 3.0h; | General procedure: A Neu5Ac or Neu5PhAc standard sample (1, 2, 4, or 6 mug) was mixed with a DMB reaction solution (150 muL containing 0.5 mg DMB, excessive) in 1.4 M acetic acid, 18 mM of sodium hydrosulfite, and 0.75 M of beta-mercaptoethanol.The reaction mixture was stirred at 50 C for 3 h, and then filtered off through a 0.22 mum film. The filtrate (10 muL) was analyzed by RP-HPLC (C18 column, 250× 4.6 mm, 0.5 mum) using gradient eluents of water and acetonitrile containing 0.1% TFA at a flow rate of 1 mL/min as described above. The eluents were monitored with a UV detector at 370 nm. The peak areas were plotted against the sample concentration to obtain the calibration curves and equations. |
Tags: 131-48-6 synthesis path| 131-48-6 SDS| 131-48-6 COA| 131-48-6 purity| 131-48-6 application| 131-48-6 NMR| 131-48-6 COA| 131-48-6 structure
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Code | Phrase |
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Prevention | |
Code | Phrase |
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P220 | Keep/Store away from clothing/combustible materials. |
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P230 | Keep wetted |
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P240 | Ground/bond container and receiving equipment. |
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P263 | Avoid contact during pregnancy/while nursing. |
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P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
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P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
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Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
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P378 | |
P380 | Evacuate area. |
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P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
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P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
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P410 | Protect from sunlight. |
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P422 | |
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P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
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Physical hazards | |
Code | Phrase |
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H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
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H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
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H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
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H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
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H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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