Structure of N-Acetylneuraminic acid
CAS No.: 131-48-6
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
N-Acetylneuraminic Acid is the predominant sialic acid found in mammalian cells, used in the development of nanocarriers.
Synonyms: NANA; Lactaminic acid; NPC-09
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CAS No. : | 131-48-6 |
Formula : | C11H19NO9 |
M.W : | 309.27 |
SMILES Code : | [C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)([C@H](CC(C(O)=O)=O)O)NC(C)=O |
Synonyms : |
NANA; Lactaminic acid; NPC-09
|
MDL No. : | MFCD00006620 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
In Vitro:
Concentration | Treated Time | Description | References |
293 cells | 3 mM | 3 days | To evaluate the cytotoxicity of SubAB on 293 cells, results showed significantly increased sensitivity to SubAB in cells supplemented with Neu5Gc. | PMC2723748 |
MDA-MB-231 cells | 3 mM | 3 days | To evaluate the cytotoxicity of SubAB on MDA-MB-231 cells, results showed significantly increased sensitivity to SubAB in cells supplemented with Neu5Gc. | PMC2723748 |
HUVECs | 5-20 mM | 12 h | To investigate the cytotoxicity of Neu5Ac on HUVECs and its effect on the expression of pyroptosis markers. Results showed that Neu5Ac increased cytotoxicity in a dose-dependent manner and upregulated the expression of pyroptosis markers (GSDMD-N, NLRP3 inflammasome, Caspase-1, IL-1β, and IL-18). | PMC11561128 |
EA.hy926 cells | 5-20 mM | 12 h | To investigate the cytotoxicity of Neu5Ac on EA.hy926 cells and its effect on the expression of pyroptosis markers. Results showed that Neu5Ac increased cytotoxicity in a dose-dependent manner and upregulated the expression of pyroptosis markers (GSDMD-N, NLRP3 inflammasome, Caspase-1, IL-1β, and IL-18). | PMC11561128 |
T84 cells | 5 mM | 3 days | To study the metabolic incorporation of Neu5Ac into cell surface glycans, T84 cells successfully incorporated Neu5Ac into their surface glycans. | PMC6023241 |
In Vivo:
Administration | Dosage | Frequency | Description | References |
ApoE−/− mice | High-fat diet-induced atherosclerosis model | Injection | 60 mg/kg | Twice a week for 8 weeks, followed by once a day for 4 weeks | To investigate the effect of Neu5Ac on atherosclerosis progression. Results showed that Neu5Ac injection increased lipid accumulation in the aortic tree and aortic sinus, promoted plaque formation, and upregulated the expression of pyroptosis markers (NLRP3, Caspase-1, and IL-18). | PMC11561128 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT03006289 | - | Unknown | November 2017 | - | |
NCT01417533 | - | Recruiting | - | United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Recruiting Bethesda, Maryland, United States, 20892 Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-441-1222 ext TTY8864111010 prpl@cc.nih.gov Less << | |
NCT03222804 | Microbial Colonization | Not Applicable | Withdrawn(Withdrawn due to los... More >>s of funding) Less << | - | United States, California ... More >> University of California, Davis Medical Center Sacramento, California, United States, 95817 Less << |
NCT03496571 | Eosinophilic Gastritis ... More >> Eosinophilic Gastroenteritis Less << | Phase 2 | Recruiting | September 2019 | - |
NCT02457338 | Healthy | Phase 1 | Active, not recruiting | June 2027 | United States, California ... More >> University of California, Davis Medical Center Sacramento, California, United States, 95817 Less << |
NCT01967238 | Healthy | Not Applicable | Recruiting | March 2020 | United States, New York ... More >> The Rockefeller University Recruiting New York, New York, United States, 10065 Contact: Recruitment Specialist 800-782-2737 Less << |
NCT00298233 | Influenza Avi... More >>an Influenza Severe Influenza Less << | Phase 2 | Completed | - | Singapore ... More >> Changi General Hospital Singapore, Singapore National University Hospital, National University of Singapore Singapore, Singapore Tan Tock Seng Hospital Singapore, Singapore Thailand Queen Sirikit National Institute of Child Health Bangkok, Thailand Siriraj Hospital Mahidol University Bangkok, Thailand Bamrasnaradura Infectious Disease Institute Nonthaburi, Thailand Chest Disease Institute Nonthaburi, Thailand Vietnam National Hospital of Pediatrics Hanoi, Vietnam National Institute fof Infectious and Tropical Diseases Hanoi, Vietnam Children's Hospital #1 Ho Chi Minh City, Vietnam Hospital for Tropical Diseases Ho Chi Minh City, Vietnam Pediatric Hospital #2 Ho Chi Minh City, Vietnam Less << |
NCT03379311 | Atopic Keratoconjunctivitis ... More >> Vernal Keratoconjunctivitis Perennial Allergic Conjunctivitis Less << | Phase 1 | Active, not recruiting | August 2019 | United States, California ... More >> Byers Eye Institute at Stanford University Palo Alto, California, United States, 94303 United States, Florida Riverside Clinical Research Edgewater, Florida, United States, 32132 United States, Maryland University of Maryland, Department of Ophthalmology and Visual Sciences Baltimore, Maryland, United States, 21201 United States, Massachusetts Ocular Immunology and Uveitis Foundation Waltham, Massachusetts, United States, 02451 United States, Missouri Tauber Eye Center Kansas City, Missouri, United States, 64111 Ophthalmology Associates Saint Louis, Missouri, United States, 63131 United States, New Jersey Metropolitan Eye Research and Surgery Institute Palisades Park, New Jersey, United States, 07650 United States, Pennsylvania UPMC Eye Center Pittsburgh, Pennsylvania, United States, 15213 Less << |
NCT03664960 | Eosinophilic Gastritis ... More >> Eosinophilic Gastroenteritis Less << | Phase 2 | Enrolling by invitation | April 2020 | United States, Arizona ... More >> Phoenician Centers for Research and Innovation Phoenix, Arizona, United States, 85021 United States, Florida Riverside Clinical Research Edgewater, Florida, United States, 32132 United States, Illinois Northwestern Chicago, Illinois, United States, 60611 United States, Iowa University of Iowa Iowa City, Iowa, United States, 52242 United States, Massachusetts Tufts Medical Center Boston, Massachusetts, United States, 02111 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 United States, North Carolina University of North Carolina - Chapel Hill Chapel Hill, North Carolina, United States, 27599 United States, Tennessee Vanderbilt University Nashville, Tennessee, United States, 37212 United States, Utah University of Utah Salt Lake City, Utah, United States, 84132 Less << |
NCT01698879 | Novo Acute Myeloid Leukemia | Phase 2 | Unknown | December 2016 | Spain ... More >> Hospital Germans Trias i Pujol Badalona, Barcelona, Spain, 08916 Hospital de la Santa Creu i Sant Pau Barcelona, Spain, 08025 Hospital Clinic Barcelona Barcelona, Spain, 08036 Hospital Clinico Universitario de Salamanca Salamanca, Spain, 37007 Hospital Universitario Virgen del Rocio Sevilla, Spain, 41013 Hospital Clínico Universitario de Valencia Valencia, Spain, 496010 Less << |
NCT00298233 | - | Completed | - | - | |
NCT03436797 | Chronic Urticaria | Phase 2 | Active, not recruiting | July 2019 | United States, Florida ... More >> Riverside Clinical Research Edgewater, Florida, United States, 32132 United States, Ohio Bernstein Clinical Research Center Cincinnati, Ohio, United States, 45231 Germany Charite University Medicine Berlin, Germany, 10117 University Medical Center of Johannes Gutenberg-University Mainz Mainz, Germany, 55131 Less << |
NCT01965626 | Thrombocytopenia | Phase 2 | Recruiting | September 2019 | China, Shandong ... More >> Qilu hospital, Shandong University Recruiting Jinan, Shandong, China, 250012 Contact: Ming Hou houming@medmail.com.cn Principal Investigator: Ming Hou Less << |
NCT02736188 | Hereditary Inclusion Body Myop... More >>athy Distal Myopathy With Rimmed Vacuoles Distal Myopathy, Nonaka Type GNE Myopathy Quadriceps Sparing Myopathy Less << | Phase 3 | Terminated | - | United States, California ... More >> UCLA Los Angeles, California, United States, 90095 University of California, Irvine Orange, California, United States, 92868 United States, Missouri Washington University School of Medicine, St. Louis Saint Louis, Missouri, United States, 63110 United States, New York New York University School of Medicine New York, New York, United States, 10016 Icahn School of Medicine at Mount Sinai New York, New York, United States, 10029 Bulgaria UMHAT Alexandrovska, Bulgaria Sofia, Bulgaria, 1431 Canada, Ontario McMaster University Hamilton, Ontario, Canada, L8N 3Z5 France CHU La Réunion - site GHSR Saint-Pierre, Reunion, France Institut de Myologie GH Pitié-Salpêtrière Paris, France Israel Hadassah-Hebrew University Medical Center Jerusalem, Israel Italy University of Messina Messina, Italy University of Milan Milan, Italy Università Cattolica Rome, Italy United Kingdom The Newcastle upon Tyne Hospitals Newcastle Upon Tyne, Tyne And Wear, United Kingdom, NE1 4LP Less << |
NCT03457974 | Cardiac Disease ... More >> Dental Caries Less << | Not Applicable | Completed | - | - |
NCT00195637 | Hereditary Inclusion Body Myop... More >>athy Less << | Phase 1 | Completed | - | United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less << |
NCT01634750 | Hereditary Inclusion Body Myop... More >>athy (HIBM) GNE Myopathy Less << | Phase 1 | Completed | - | United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less << |
NCT02731690 | Hereditary Inclusion Body Myop... More >>athy Distal Myopathy With Rimmed Vacuoles Distal Myopathy, Nonaka Type GNE Myopathy Quadriceps Sparing Myopathy Inclusion Body Myopathy 2 Less << | Phase 2 | Terminated | - | United States, California ... More >> University of California, Irvine Orange, California, United States, 92868 United States, Missouri Washington University, St. Louis Saint Louis, Missouri, United States, 63110 United States, New York NYU Langone Medical Center New York, New York, United States, 10016 Bulgaria University Alexandrovska, Bulgaria Sofia, Bulgaria, 1431 Canada, Ontario McMaster University Hamilton, Ontario, Canada, L8N 3Z5 Less << |
NCT02639260 | Kidney Disease | Phase 1 | Completed | - | United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less << |
NCT01830972 | GNE Myopathy ... More >>Hereditary Inclusion Body Myopathy (HIBM) Less << | Phase 2 | Completed | - | United States, California ... More >> UCLA Medical Center Los Angeles, California, United States, 90095 United States, Missouri Washington University School of Medicine Saint Louis, Missouri, United States, 63110 United States, New York NYU Medical Center New York, New York, United States, 10016 Israel Hadassah University Hospital Jerusalem, Israel Less << |
NCT02377921 | - | Completed | - | - | |
NCT02346461 | GNE Myopathy | Phase 1 Phase 2 | Completed | - | United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less << |
NCT01517880 | GNE Myopathy ... More >>Hereditary Inclusion Body Myopathy Less << | Phase 2 | Completed | - | United States, California ... More >> UCLA Medical Center Los Angeles, California, United States, 90095 United States, Missouri Washington University School of Medicine St. Louis, Missouri, United States, 63110 United States, New York New York University School of Medicine New York, New York, United States, 10016 Israel Hadassah University Hospital Jerusalem, Israel, 91120 Less << |
NCT01830972 | - | Completed | - | - | |
NCT02377921 | Hereditary Inclusion Body Myop... More >>athy Distal Myopathy With Rimmed Vacuoles Distal Myopathy, Nonaka Type GNE Myopathy Less << | Phase 3 | Completed | - | United States, California ... More >> University of California, Irvine Irvine, California, United States, 92697 United States, Missouri Washington University School of Medicine Saint Louis, Missouri, United States, 63110 United States, New York New York University School of Medicine New York, New York, United States, 10016 Icahn School of Medicine at Mount Sinai New York, New York, United States, 10029 Bulgaria UMHAT "Alexandrovska" Sofia, Bulgaria Canada, Ontario McMaster University Hamilton, Ontario, Canada, L8N3Z5 France CHU La Réunion - site GHSR Saint-Pierre, Reunion, France Institut de Myologie GH Pitié-Salpêtrière Paris, France Israel Hadassah-Hebrew University Medical Center Jerusalem, Israel Italy University of Messina Messina, Italy University of Milan Milan, Italy Università Cattolica Rome, Italy United Kingdom The Newcastle upon Tyne Hospitals Newcastle Upon Tyne, Tyne And Wear, United Kingdom, NE1 4LP Less << |
NCT03745027 | in Vitro Fertilization | Not Applicable | Completed | - | Turkey ... More >> Kanuni SSRTH Istanbul, Turkey, 34303 Less << |
NCT01236898 | Nonaka Myopathy ... More >> Hereditary Inclusion Body Myopathy Less << | Phase 1 | Completed | - | Japan ... More >> Tohoku University Hospital Sendai, Miyagi, Japan, 980-8574 Less << |
NCT03545568 | N-Acetylneuraminic Acid Storag... More >>e Disease Less << | Not Applicable | Completed | - | Italy ... More >> Struttura Semplice Dipartimentale di Genetica Clinica Reggio Emilia, Italy, 42123 Switzerland Lausanne University Hospital Lausanne, Vaud, Switzerland, 1011 Less << |
NCT01359319 | Hereditary Inclusion Body Myop... More >>athy (HIBM) Less << | Phase 1 | Completed | - | United States, California ... More >> West Coast Clinical Trials Costa Mesa, California, United States, 92626 United States, New York Clinilabs New York City, New York, United States, 10019 Less << |
NCT03775967 | - | Recruiting | July 2019 | India ... More >> AB shetty institute of dental sciences Recruiting Mangalore, India Contact: biju thomas, Phd 919448953418 bijunicy@yahoo.co.uk Contact: amitha ramesh, MDS 919448953418 amitha.ramesh@gmail.com Less << | |
NCT02845609 | Thrombocytopenia | Phase 2 | Completed | - | - |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
3.23mL 0.65mL 0.32mL |
16.17mL 3.23mL 1.62mL |
32.33mL 6.47mL 3.23mL |
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Dissolving Methods |
The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
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