Home Cart Sign in  
Chemical Structure| 131-48-6 Chemical Structure| 131-48-6

Structure of N-Acetylneuraminic acid
CAS No.: 131-48-6

Chemical Structure| 131-48-6

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

N-Acetylneuraminic Acid is the predominant sialic acid found in mammalian cells, used in the development of nanocarriers.

Synonyms: NANA; Lactaminic acid; NPC-09

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of N-Acetylneuraminic acid

CAS No. :131-48-6
Formula : C11H19NO9
M.W : 309.27
SMILES Code : [C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)([C@H](CC(C(O)=O)=O)O)NC(C)=O
Synonyms :
NANA; Lactaminic acid; NPC-09
MDL No. :MFCD00006620

Safety of N-Acetylneuraminic acid

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
293 cells 3 mM 3 days To evaluate the cytotoxicity of SubAB on 293 cells, results showed significantly increased sensitivity to SubAB in cells supplemented with Neu5Gc. PMC2723748
MDA-MB-231 cells 3 mM 3 days To evaluate the cytotoxicity of SubAB on MDA-MB-231 cells, results showed significantly increased sensitivity to SubAB in cells supplemented with Neu5Gc. PMC2723748
HUVECs 5-20 mM 12 h To investigate the cytotoxicity of Neu5Ac on HUVECs and its effect on the expression of pyroptosis markers. Results showed that Neu5Ac increased cytotoxicity in a dose-dependent manner and upregulated the expression of pyroptosis markers (GSDMD-N, NLRP3 inflammasome, Caspase-1, IL-1β, and IL-18). PMC11561128
EA.hy926 cells 5-20 mM 12 h To investigate the cytotoxicity of Neu5Ac on EA.hy926 cells and its effect on the expression of pyroptosis markers. Results showed that Neu5Ac increased cytotoxicity in a dose-dependent manner and upregulated the expression of pyroptosis markers (GSDMD-N, NLRP3 inflammasome, Caspase-1, IL-1β, and IL-18). PMC11561128
T84 cells 5 mM 3 days To study the metabolic incorporation of Neu5Ac into cell surface glycans, T84 cells successfully incorporated Neu5Ac into their surface glycans. PMC6023241

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
ApoE−/− mice High-fat diet-induced atherosclerosis model Injection 60 mg/kg Twice a week for 8 weeks, followed by once a day for 4 weeks To investigate the effect of Neu5Ac on atherosclerosis progression. Results showed that Neu5Ac injection increased lipid accumulation in the aortic tree and aortic sinus, promoted plaque formation, and upregulated the expression of pyroptosis markers (NLRP3, Caspase-1, and IL-18). PMC11561128

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT03006289 - Unknown November 2017 -
NCT01417533 - Recruiting - United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Recruiting Bethesda, Maryland, United States, 20892 Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)    800-441-1222 ext TTY8864111010    prpl@cc.nih.gov Less <<
NCT03222804 Microbial Colonization Not Applicable Withdrawn(Withdrawn due to los... More >>s of funding) Less << - United States, California ... More >> University of California, Davis Medical Center Sacramento, California, United States, 95817 Less <<
NCT03496571 Eosinophilic Gastritis ... More >> Eosinophilic Gastroenteritis Less << Phase 2 Recruiting September 2019 -
NCT02457338 Healthy Phase 1 Active, not recruiting June 2027 United States, California ... More >> University of California, Davis Medical Center Sacramento, California, United States, 95817 Less <<
NCT01967238 Healthy Not Applicable Recruiting March 2020 United States, New York ... More >> The Rockefeller University Recruiting New York, New York, United States, 10065 Contact: Recruitment Specialist    800-782-2737 Less <<
NCT00298233 Influenza Avi... More >>an Influenza Severe Influenza Less << Phase 2 Completed - Singapore ... More >> Changi General Hospital Singapore, Singapore National University Hospital, National University of Singapore Singapore, Singapore Tan Tock Seng Hospital Singapore, Singapore Thailand Queen Sirikit National Institute of Child Health Bangkok, Thailand Siriraj Hospital Mahidol University Bangkok, Thailand Bamrasnaradura Infectious Disease Institute Nonthaburi, Thailand Chest Disease Institute Nonthaburi, Thailand Vietnam National Hospital of Pediatrics Hanoi, Vietnam National Institute fof Infectious and Tropical Diseases Hanoi, Vietnam Children's Hospital #1 Ho Chi Minh City, Vietnam Hospital for Tropical Diseases Ho Chi Minh City, Vietnam Pediatric Hospital #2 Ho Chi Minh City, Vietnam Less <<
NCT03379311 Atopic Keratoconjunctivitis ... More >> Vernal Keratoconjunctivitis Perennial Allergic Conjunctivitis Less << Phase 1 Active, not recruiting August 2019 United States, California ... More >> Byers Eye Institute at Stanford University Palo Alto, California, United States, 94303 United States, Florida Riverside Clinical Research Edgewater, Florida, United States, 32132 United States, Maryland University of Maryland, Department of Ophthalmology and Visual Sciences Baltimore, Maryland, United States, 21201 United States, Massachusetts Ocular Immunology and Uveitis Foundation Waltham, Massachusetts, United States, 02451 United States, Missouri Tauber Eye Center Kansas City, Missouri, United States, 64111 Ophthalmology Associates Saint Louis, Missouri, United States, 63131 United States, New Jersey Metropolitan Eye Research and Surgery Institute Palisades Park, New Jersey, United States, 07650 United States, Pennsylvania UPMC Eye Center Pittsburgh, Pennsylvania, United States, 15213 Less <<
NCT03664960 Eosinophilic Gastritis ... More >> Eosinophilic Gastroenteritis Less << Phase 2 Enrolling by invitation April 2020 United States, Arizona ... More >> Phoenician Centers for Research and Innovation Phoenix, Arizona, United States, 85021 United States, Florida Riverside Clinical Research Edgewater, Florida, United States, 32132 United States, Illinois Northwestern Chicago, Illinois, United States, 60611 United States, Iowa University of Iowa Iowa City, Iowa, United States, 52242 United States, Massachusetts Tufts Medical Center Boston, Massachusetts, United States, 02111 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 United States, North Carolina University of North Carolina - Chapel Hill Chapel Hill, North Carolina, United States, 27599 United States, Tennessee Vanderbilt University Nashville, Tennessee, United States, 37212 United States, Utah University of Utah Salt Lake City, Utah, United States, 84132 Less <<
NCT01698879 Novo Acute Myeloid Leukemia Phase 2 Unknown December 2016 Spain ... More >> Hospital Germans Trias i Pujol Badalona, Barcelona, Spain, 08916 Hospital de la Santa Creu i Sant Pau Barcelona, Spain, 08025 Hospital Clinic Barcelona Barcelona, Spain, 08036 Hospital Clinico Universitario de Salamanca Salamanca, Spain, 37007 Hospital Universitario Virgen del Rocio Sevilla, Spain, 41013 Hospital Clínico Universitario de Valencia Valencia, Spain, 496010 Less <<
NCT00298233 - Completed - -
NCT03436797 Chronic Urticaria Phase 2 Active, not recruiting July 2019 United States, Florida ... More >> Riverside Clinical Research Edgewater, Florida, United States, 32132 United States, Ohio Bernstein Clinical Research Center Cincinnati, Ohio, United States, 45231 Germany Charite University Medicine Berlin, Germany, 10117 University Medical Center of Johannes Gutenberg-University Mainz Mainz, Germany, 55131 Less <<
NCT01965626 Thrombocytopenia Phase 2 Recruiting September 2019 China, Shandong ... More >> Qilu hospital, Shandong University Recruiting Jinan, Shandong, China, 250012 Contact: Ming Hou       houming@medmail.com.cn    Principal Investigator: Ming Hou Less <<
NCT02736188 Hereditary Inclusion Body Myop... More >>athy Distal Myopathy With Rimmed Vacuoles Distal Myopathy, Nonaka Type GNE Myopathy Quadriceps Sparing Myopathy Less << Phase 3 Terminated - United States, California ... More >> UCLA Los Angeles, California, United States, 90095 University of California, Irvine Orange, California, United States, 92868 United States, Missouri Washington University School of Medicine, St. Louis Saint Louis, Missouri, United States, 63110 United States, New York New York University School of Medicine New York, New York, United States, 10016 Icahn School of Medicine at Mount Sinai New York, New York, United States, 10029 Bulgaria UMHAT Alexandrovska, Bulgaria Sofia, Bulgaria, 1431 Canada, Ontario McMaster University Hamilton, Ontario, Canada, L8N 3Z5 France CHU La Réunion - site GHSR Saint-Pierre, Reunion, France Institut de Myologie GH Pitié-Salpêtrière Paris, France Israel Hadassah-Hebrew University Medical Center Jerusalem, Israel Italy University of Messina Messina, Italy University of Milan Milan, Italy Università Cattolica Rome, Italy United Kingdom The Newcastle upon Tyne Hospitals Newcastle Upon Tyne, Tyne And Wear, United Kingdom, NE1 4LP Less <<
NCT03457974 Cardiac Disease ... More >> Dental Caries Less << Not Applicable Completed - -
NCT00195637 Hereditary Inclusion Body Myop... More >>athy Less << Phase 1 Completed - United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less <<
NCT01634750 Hereditary Inclusion Body Myop... More >>athy (HIBM) GNE Myopathy Less << Phase 1 Completed - United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less <<
NCT02731690 Hereditary Inclusion Body Myop... More >>athy Distal Myopathy With Rimmed Vacuoles Distal Myopathy, Nonaka Type GNE Myopathy Quadriceps Sparing Myopathy Inclusion Body Myopathy 2 Less << Phase 2 Terminated - United States, California ... More >> University of California, Irvine Orange, California, United States, 92868 United States, Missouri Washington University, St. Louis Saint Louis, Missouri, United States, 63110 United States, New York NYU Langone Medical Center New York, New York, United States, 10016 Bulgaria University Alexandrovska, Bulgaria Sofia, Bulgaria, 1431 Canada, Ontario McMaster University Hamilton, Ontario, Canada, L8N 3Z5 Less <<
NCT02639260 Kidney Disease Phase 1 Completed - United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less <<
NCT01830972 GNE Myopathy ... More >>Hereditary Inclusion Body Myopathy (HIBM) Less << Phase 2 Completed - United States, California ... More >> UCLA Medical Center Los Angeles, California, United States, 90095 United States, Missouri Washington University School of Medicine Saint Louis, Missouri, United States, 63110 United States, New York NYU Medical Center New York, New York, United States, 10016 Israel Hadassah University Hospital Jerusalem, Israel Less <<
NCT02377921 - Completed - -
NCT02346461 GNE Myopathy Phase 1 Phase 2 Completed - United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Less <<
NCT01517880 GNE Myopathy ... More >>Hereditary Inclusion Body Myopathy Less << Phase 2 Completed - United States, California ... More >> UCLA Medical Center Los Angeles, California, United States, 90095 United States, Missouri Washington University School of Medicine St. Louis, Missouri, United States, 63110 United States, New York New York University School of Medicine New York, New York, United States, 10016 Israel Hadassah University Hospital Jerusalem, Israel, 91120 Less <<
NCT01830972 - Completed - -
NCT02377921 Hereditary Inclusion Body Myop... More >>athy Distal Myopathy With Rimmed Vacuoles Distal Myopathy, Nonaka Type GNE Myopathy Less << Phase 3 Completed - United States, California ... More >> University of California, Irvine Irvine, California, United States, 92697 United States, Missouri Washington University School of Medicine Saint Louis, Missouri, United States, 63110 United States, New York New York University School of Medicine New York, New York, United States, 10016 Icahn School of Medicine at Mount Sinai New York, New York, United States, 10029 Bulgaria UMHAT "Alexandrovska" Sofia, Bulgaria Canada, Ontario McMaster University Hamilton, Ontario, Canada, L8N3Z5 France CHU La Réunion - site GHSR Saint-Pierre, Reunion, France Institut de Myologie GH Pitié-Salpêtrière Paris, France Israel Hadassah-Hebrew University Medical Center Jerusalem, Israel Italy University of Messina Messina, Italy University of Milan Milan, Italy Università Cattolica Rome, Italy United Kingdom The Newcastle upon Tyne Hospitals Newcastle Upon Tyne, Tyne And Wear, United Kingdom, NE1 4LP Less <<
NCT03745027 in Vitro Fertilization Not Applicable Completed - Turkey ... More >> Kanuni SSRTH Istanbul, Turkey, 34303 Less <<
NCT01236898 Nonaka Myopathy ... More >> Hereditary Inclusion Body Myopathy Less << Phase 1 Completed - Japan ... More >> Tohoku University Hospital Sendai, Miyagi, Japan, 980-8574 Less <<
NCT03545568 N-Acetylneuraminic Acid Storag... More >>e Disease Less << Not Applicable Completed - Italy ... More >> Struttura Semplice Dipartimentale di Genetica Clinica Reggio Emilia, Italy, 42123 Switzerland Lausanne University Hospital Lausanne, Vaud, Switzerland, 1011 Less <<
NCT01359319 Hereditary Inclusion Body Myop... More >>athy (HIBM) Less << Phase 1 Completed - United States, California ... More >> West Coast Clinical Trials Costa Mesa, California, United States, 92626 United States, New York Clinilabs New York City, New York, United States, 10019 Less <<
NCT03775967 - Recruiting July 2019 India ... More >> AB shetty institute of dental sciences Recruiting Mangalore, India Contact: biju thomas, Phd    919448953418    bijunicy@yahoo.co.uk    Contact: amitha ramesh, MDS    919448953418    amitha.ramesh@gmail.com Less <<
NCT02845609 Thrombocytopenia Phase 2 Completed - -

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.23mL

0.65mL

0.32mL

16.17mL

3.23mL

1.62mL

32.33mL

6.47mL

3.23mL

Dissolving Methods
The prepared working fluid is recommended to be prepared now and used up as soon as possible in a short period of time. The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1

References

 

Historical Records

Categories