Alternatived Products of [ 1310048-95-3 ]
Product Details of [ 1310048-95-3 ]
| CAS No. : | 1310048-95-3 |
MDL No. : | MFCD10698518 |
| Formula : |
C13H18BFO2
|
Boiling Point : |
- |
| Linear Structure Formula : | - |
InChI Key : | LIQLVQAWDJTUIM-UHFFFAOYSA-N |
| M.W : | 236.09 |
Pubchem ID : | 71306021 |
| Synonyms : |
|
Safety of [ 1310048-95-3 ]
Application In Synthesis of [ 1310048-95-3 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 1310048-95-3 ]
- 1
-
[ 57606-65-2 ]
-
[ 78782-17-9 ]
-
[ 1310048-95-3 ]
| Yield | Reaction Conditions | Operation in experiment |
| 72% |
With tetra(n-butyl)ammonium hydroxide; palladium diacetate; triphenylphosphine In 1,4-dioxane; water at 20℃; Inert atmosphere; |
|
- 2
-
[ 18680-27-8 ]
-
[ 1310048-95-3 ]
-
(3aS,4S,6S,7aR)-2-(3-fluorobenzyl)-5,5,7a-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborole
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
| 98% |
In diethyl ether at 20℃; for 24h; Inert atmosphere; Schlenk technique; |
|
Reference：
[1]He, Zhi-Tao; Li, Rui-Peng; Liao, Qi-Ying; Ma, Chao; Wang, Miao; Zhao, Wei-Cheng
[Journal of the American Chemical Society, 2022, vol. 144, # 6, p. 2460 - 2467]
- 3
-
[ 56181-39-6 ]
-
[ 1310048-95-3 ]
-
4-chloro-5-[(3-fluorophenyl)methyl]pyrimidine
[ No CAS ]
| Yield | Reaction Conditions | Operation in experiment |
|
With potassium carbonate |
90.a.E E)
E) 4-chloro-5-[(3-fluorophenyl)methyl]pyrimidine To a mixture of 5-bromo-4-chloro-pyrimidine (300 mg), 2-[(3-fluorophenyl)methyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (785 mg), dioxane (10 mL) and water (0.5 mL) were added Pd(dppf)Cl2 (113 mg) and potassium carbonate (472 mg) at room temperature. The mixture was stirred under nitrogen atmosphere at 85° C. for 12 hr. The reaction solution was filtered through Celite, and the filtrate was concentrated. The residue was purified by preparative TLC (petroleum ether/ethyl acetate=3/1) to give the title compound (140 mg). MS: [M+H]+ 223.6. |
| 140 mg |
With palladium (II) [1,1'-bis(diphenylphosphanyl)ferrocene] dichloride; potassium carbonate In 1,4-dioxane; water monomer at 85℃; for 12h; Inert atmosphere; |
90.a.E E) 4-chloro-5-[(3-fluorophenyl)methyl]pyrimidine
To a mixture of 5-bromo-4-chloro-pyrimidine (300 mg), 2-[(3-fluorophenyl)methyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (785 mg), dioxane (10 mL) and water (0.5 mL) were added Pd(dppf)Cl2 (113 mg) and potassium carbonate (472 mg) at room temperature. The mixture was stirred under nitrogen atmosphere at 85° C. for 12 hr. The reaction solution was filtered through Celite, and the filtrate was concentrated. The residue was purified by preparative TLC (petroleum ether/ethyl acetate=3/1) to give the title compound (140 mg). MS: [M+H]+ 223.6. |
| 140 mg |
With palladium (II) [1,1'-bis(diphenylphosphanyl)ferrocene] dichloride; potassium carbonate In 1,4-dioxane; water monomer at 85℃; for 12h; Inert atmosphere; |
90.a.E E) 4-chloro-5-[(3-fluorophenyl)methyl]pyrimidine
To a mixture of 5-bromo-4-chloro-pyrimidine (300 mg), 2-[(3-fluorophenyl)methyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (785 mg), dioxane (10 mL) and water (0.5 mL) were added Pd(dppf)Cl2 (113 mg) and potassium carbonate (472 mg) at room temperature. The mixture was stirred under nitrogen atmosphere at 85° C. for 12 hr. The reaction solution was filtered through Celite, and the filtrate was concentrated. The residue was purified by preparative TLC (petroleum ether/ethyl acetate=3/1) to give the title compound (140 mg). MS: [M+H]+ 223.6. |
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