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Chemical Structure| 131056-82-1 Chemical Structure| 131056-82-1

Structure of 131056-82-1

Chemical Structure| 131056-82-1

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Product Details of [ 131056-82-1 ]

CAS No. :131056-82-1
Formula : C14H9NO
M.W : 207.23
SMILES Code : O=C=NC1C2=C(C3=C1C=CC=C3)C=CC=C2

Safety of [ 131056-82-1 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H312-H315-H319-H332-H334-H335
Precautionary Statements:P261-P280-P305+P351+P338-P342+P311
Class:6.1
UN#:2206
Packing Group:

Application In Synthesis of [ 131056-82-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 131056-82-1 ]

[ 131056-82-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 32315-10-9 ]
  • [ 525-03-1 ]
  • [ 131056-82-1 ]
YieldReaction ConditionsOperation in experiment
With triethylamine; In 1,2-dichloro-ethane;Reflux; To a solution of 25a (0.25 g) and triethylamine (1 mL) in 1,2-dichloroethane (10 mL), was added triphosgene (0.5 g) with stirring. The mixture was stirred at room temperature for 1 h, and heated to supernatant. Then the mixture was condensed, washed with acetone and filtered to obtain a solution of 24a in acetone. This solution was used directly for next reaction. To the solution was added 23c (0.37g) with stirring at room temperature. Then the mixture was reacted at room temperature for 10 h. The solvent was evaporated in vacuum to give the crude product. It was purified by flash column chromatography on silica gel, eluted with a mixture of THF/ DCM/PE (1:3:5, v/v/v), to afford 4p (0.38g, 62%) as a white solid: mp 245-248 C; 1H NMR (400 MHz, DMSO-d6) δ: 7.82 (d, J = 7.5 Hz, 2H), 7.51 (t, J = 7.9 Hz, 6H), 7.39 (t, J = 7.3 Hz, 6H), 7.35-7.29 (m, 2H), 7.26 (t, J = 7.4 Hz, 2H), 7.20 (t, J = 8.4 Hz, 1H), 6.74 (d, J = 8.4 Hz, 2H), 6.44 (d, J = 8.6 Hz, 1H), 5.88-5.77 (m, 2H), 5.16 (s, 4H), 4.52 (d, J = 4.5 Hz, 2H).
 

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