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Chemical Structure| 131210-57-6 Chemical Structure| 131210-57-6

Structure of 131210-57-6

Chemical Structure| 131210-57-6

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Product Details of [ 131210-57-6 ]

CAS No. :131210-57-6
Formula : C12H11FO3
M.W : 222.21
SMILES Code : O=C(C(CCC1=C2C=CC(F)=C1)C2=O)OC

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Application In Synthesis of [ 131210-57-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 131210-57-6 ]

[ 131210-57-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 703-67-3 ]
  • [ 616-38-6 ]
  • [ 131210-57-6 ]
YieldReaction ConditionsOperation in experiment
With sodium hydride; at 20 - 90℃; for 1.5h; To a solution of NaH (2.7 g, 67 mmol) in dimethyl carbonate (25mL) was added the solution of 6-fluoro-3, 4-dihydronaphthalen-1 (2H) -one (5 g, 30.45 mmol) in dimethyl carbonate (25 mL) . The mixture was stirred at rt for 30 min then at 90 for 1 h. The reaction mixture was turned from the suspension to the solid state. The reaction was quenched by ice water (100 mL) , extracted with EA (100 mL x 3) . The combined organic layer was washed by brine (100 mL) , dried over anhydrous sodium sulfate then concentrated to get the crude product (6.8g, 100) as yellow oil, which was used in next step directly.1H NMR (400 MHz, CDCl3) delta 8.15?7.70 (m, 1H) , 7.10 ?6.77 (m, 2H) , 3.76 (s, 3H) , 3.59 (dd, J10.0, 4.8 Hz, 1H) , 3.11?2.90 (m, 1H) , 2.78 (t, J7.8 Hz, 1H) , 2.78?2.52 (m, 1H) , 2.52?2.30 (m, 1H) . MS: M/e 223 (M+1)+
 

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