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Chemical Structure| 1315544-56-9 Chemical Structure| 1315544-56-9

Structure of 1315544-56-9

Chemical Structure| 1315544-56-9

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Product Details of [ 1315544-56-9 ]

CAS No. :1315544-56-9
Formula : C11H8BrN3O
M.W : 278.10
SMILES Code : O=C1N(C2=CNN=C2)CC3=C1C=CC(Br)=C3
MDL No. :N/A

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Application In Synthesis of [ 1315544-56-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1315544-56-9 ]

[ 1315544-56-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 28466-26-4 ]
  • [ 78471-43-9 ]
  • [ 1315544-56-9 ]
YieldReaction ConditionsOperation in experiment
64% With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 110℃; for 1.5h; As shown in step 5-i of Scheme 5, methyl 4-bromo-2-(bromomethyl)benzoate (Compound 2018, 2.08 g, 6.75 mmol; prepared by reacting l-(4-bromo-2- methylphenyl)ethanone with NBS),lH-pyrazol-4-amine (561 mg, 6.75 mmol), and DIEA (873 mg, 1.18 mL, 6.75 mmol) were combined in DMF (7.78 mL) and heated at 110 C for 90 min. The reaction mixture was diluted with MeOH (60 mL) and the resulting white crystaline solid was collected by filtration and dried under vacuum to give 5-bromo-2-(lH- pyrazol-4-yl)isoindolin-l-one (Compound 2019, 1.21 g, 4.35 mmol, 64% yield): ESMS (Mu+Eta) 279.99
 

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