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Chemical Structure| 131993-96-9 Chemical Structure| 131993-96-9

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Chemical Structure| 131993-96-9

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Product Details of [ 131993-96-9 ]

CAS No. :131993-96-9
Formula : C14H14BrNO3
M.W : 324.17
SMILES Code : BrC(C=C12)=CC=C1C(C(C(OCC)=O)=CN2CC)=O
MDL No. :MFCD27955783

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 131993-96-9 ]

[ 131993-96-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 74-96-4 ]
  • [ 208580-23-8 ]
  • [ 131993-96-9 ]
YieldReaction ConditionsOperation in experiment
68.8% Intermediate 56Ethyl 7-bromo-1-ethyl-4-oxo-1,4-dihydroquinoline-3-carboxylateEthyl 7-bromo-4-oxo-1,4-dihydroquinoline-3-carboxylate (Intermediate 55, 1.0 g, 3.3 mM) was dissolved in dimethylformamide (20 mL) and potassium carbonate (1.39 g, 10.1 mM) was added. After stirring the mixture for 10 min, ethyl bromide (0.76 mL, 10.1 mM) was added, and the reaction mixture was heated to 80 C. for 3 h. After completion of the reaction, the reaction mixture was cooled to room temperature, filtered through celite, and concentrated under reduced pressure to dryness. The residue was diluted with diethyl ether to obtain a solid which was filtered and dried to afford 750 mg (68.8%) of ethyl 7-bromo-1-ethyl-4-oxo-1,4-dihydroquinoline-3-carboxylate as white solid.1H NMR (400 MHz, DMSO-d6):delta 1.26 (t, 3H), 1.34 (t, 3H), 4.21 (q, 2H), 4.42 (q, 2H), 7.64 (d, 1H), 8.06 (s, 1H), 8.25 (d, 1H), 8.68 (s, 1H).LC-MS: m/z 324 (M+H).
 

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