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Chemical Structure| 132453-63-5 Chemical Structure| 132453-63-5

Structure of 132453-63-5

Chemical Structure| 132453-63-5

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Product Details of [ 132453-63-5 ]

CAS No. :132453-63-5
Formula : C6H6ClN3O
M.W : 171.58
SMILES Code : CC(NC1=NC(Cl)=CN=C1)=O
MDL No. :MFCD01201713

Safety of [ 132453-63-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 132453-63-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 132453-63-5 ]

[ 132453-63-5 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 108-24-7 ]
  • [ 33332-28-4 ]
  • [ 132453-63-5 ]
  • 2
  • [ 75-36-5 ]
  • [ 33332-28-4 ]
  • [ 132453-63-5 ]
YieldReaction ConditionsOperation in experiment
52.9% To a solution of 6-chloropyrazin-2-amine (1.00 g, 7.72 mmol) in DCM (20 mL) was added acetyl chloride (0.659 mL, 9.26 mmol) at RT and the reaction mixture was stirred for 1 h. The reaction mixture was diluted with water (100 mL) and extracted with DCM (2*100 mL). The combined organic layer was dried over sodium sulfate, filtered and evaporated under reduced pressure to give a residue which was purified by CombiFlash (REDISEP®, silica gel, 12 g, 25percent EtOAc/petroleum ether) to give N-(6-chloropyrazin-2-yl)acetamide (0.700 g, 52.9percent). LCMS Condition B-39: retention time 1.67 min, [M+1]=170.0. 1H NMR (400 MHz, DMSO-d6) delta ppm 2.14 (s, 3H), 8.47 (s, 1H), 9.29 (s, 1H), 11.09 (br s, 1H).
 

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