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[ CAS No. 132901-37-2 ] {[proInfo.proName]}

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Chemical Structure| 132901-37-2
Chemical Structure| 132901-37-2
Structure of 132901-37-2 * Storage: {[proInfo.prStorage]}
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Product Details of [ 132901-37-2 ]

CAS No. :132901-37-2 MDL No. :MFCD18070971
Formula : C7H4ClIO Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 266.46 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 132901-37-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 132901-37-2 ]

[ 132901-37-2 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 19591-17-4 ]
  • [ 132901-37-2 ]
  • [ 109-77-3 ]
  • 2-chloroindolo[1,2-a]quinazoline-7-carbonitrile [ No CAS ]
YieldReaction ConditionsOperation in experiment
55% General procedure: A dry sealed tube was charged with a magnetic stirrer, substituted<strong>[19591-17-4]N-(2-iodophenyl)acetamide</strong> (100 mg for each example,0.38 mmol), malononitrile or 2-sulfonylacetonitriles(0.46 mmol, 1.2 equiv), CuI (0.038 mmol, 0.1 equiv), L-proline(0.076 mmol, 0.2 equiv), and K2CO3 (0.76 mmol, 2 equiv) in0.77 mL of DMSO. The tube was evacuated and backfilled withargon and the process was repeated three times. The mixturewas stirred at 80 C for 12 h under an argon atmosphere.After the starting material was consumed completely,2-iodobenzaldehyde (0.4 mmol, 1.05 equiv) with 0.77 mL ofDMSO was charged successively to the tube via syringe,and then the resulting mixture was stirred at 80 C foranother 12 h under an argon atmosphere. After thereaction was complete, the reaction mixture was cooledto room temperature and the reaction mixture was partitionedbetween ethyl acetate or dichloromethane and water. Theorganic layer was separated and the aqueous layer was extractedwith ethyl acetate or dichloromethane for three times. Thecombined organic solution was washed with water, brine, driedover anhydrous Na2SO4, and concentrated under reducedpressure to give the crude product. Purification by chromatographyon silica gel using petroleum ether/ethyl acetate ordichloromethane/ethyl acetate as eluent provided the desiredproduct.
  • 2
  • [ 1080-32-6 ]
  • [ 132901-37-2 ]
  • (E)-4-chloro-2-iodo-1-(β-styryl)benzene [ No CAS ]
YieldReaction ConditionsOperation in experiment
62% Stage #1: O,O-diethyl benzylphosphonate With sodium hexamethyldisilazane In tetrahydrofuran at 0℃; for 0.166667h; Stage #2: 4-chloro-2-iodobenzaldehyde In tetrahydrofuran at 0 - 20℃; General procedure for the synthesis of o-iodo styrene derivatives 10a-c 17,18 General procedure: To a flame-dried 100 mL round-bottom flask NaHMDS (2 mmol, 1 eq) in THF (5 mL) were addedand the solution was cooled down to 0 °C. A solution of the corresponding benzyl phosphonate(II) (2 mmol, 1 eq) in THF (12 mL) was added dropwise under stirring. The reaction was stirred fora further 10 min at 0 °C, then a solution of the haloaldehyde (I) (2 mmol, 1 eq) in THF (4 mL) wasadded dropwise. The mixture was allowed to warm from 0 °C to room temperature 12-14 h understirring. The reaction mixture was quenched with water (10 mL). The aq layer was extracted withEt2O (3 x 10 mL). The combined organic layers were washed with 10% aq NaHSO3 (2 x 5 mL)and then with brine (10 mL). The combined organic layers were dried over Na2SO4 andconcentrated by evaporation in vacuo to give 10a-c. (10a: E/Z: 10:1, 10b: E, 10c: E/Z: 20:1). TheE-isomers of compounds 10a’-c’ was obtained using column chromatography (2.0% EtOAc inpetroleum ether) from mixtures of 10a-c. The E/Z ratio was determined by 1H NMR.
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