Home Cart Sign in  
Chemical Structure| 1331945-14-2 Chemical Structure| 1331945-14-2

Structure of 1331945-14-2

Chemical Structure| 1331945-14-2

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 1331945-14-2 ]

CAS No. :1331945-14-2
Formula : C7H8BFO3
M.W : 169.95
SMILES Code : OCC1=CC=C(B(O)O)C(F)=C1
MDL No. :MFCD21603758
InChI Key :YPJXLOUZOVHAIZ-UHFFFAOYSA-N
Pubchem ID :56951405

Safety of [ 1331945-14-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P210-P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P370+P378-P403+P233-P403+P235-P405-P501

Application In Synthesis of [ 1331945-14-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1331945-14-2 ]

[ 1331945-14-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 5419-55-6 ]
  • [ 222978-01-0 ]
  • [ 1331945-14-2 ]
YieldReaction ConditionsOperation in experiment
99% 4-(Hvdroxymethyl)-2-fluorophenylboronic acid.This compound was prepared according to the protocol described in Zheng, N.; Armstrong, J. D.; Eng, K. K.; Keller, J.; Liu, T.; Purick, R.; Lynch, J.; Hartner, F. W.; Volante, R. P. Tetrahedron: Asymmetry 2003, 14, 3435-3446 for analogous derivatives. Dimethylamine (1.9 mL of 2 M solution in THF, 3.7 mmol) was cooled to -78 C. n-Butyllithium (1.7 mL of 1.6 M solution in hexane, 2.7 mmol) was added dropwise within 5 min. Next <strong>[222978-01-0]4-bromo-3-fluorobenzyl alcohol</strong> (0.56 g, 2.7 mmol) dissolved in THF (1 mL) was slowly added while the temperature of the reaction mixture was kept at -78 C. After the addition of the latter reagent and stirring for 5 min, the mixture was allowed to warm to room temperature (22 C), and the solvent was removed in vacuum (10 mbar). The rest was redissolved in THF (10 mL) and cooled back to -78 C. n-butyllithium (1.8 mL of 1.6 M solution, 2.8 mmol) was added within 5 min, and the mixture was allowed to react for 1 h while being stirred. Finally, triisopropyl borate (1.5 mL, 6.5 mmol) was added dropwise, and after 1 h the unreacted compounds were quenched with NaOH solution in water (5.1 mL, 1 M) and then with water (5.1 mL). After that, the mixture was warmed to 22 C, all volatiles were removed in vacuum (10 mbar), and a mixture of water and diethyl ether was added. The aqueous phase was separated and acidified with concentrated HCI to pH 4. At these conditions the raw product was precipitated. It was purified by column chromatography on silica gel using CH2CI2/EtOAc (1/1 , v/v) as the eluent. Yield: 0.90 g (99%). Rf = 0.5 (silica, eluent CH2CI2/EtOAc, 1/1 , v/v).
 

Historical Records

Technical Information

Categories