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Chemical Structure| 1333152-99-0 Chemical Structure| 1333152-99-0

Structure of 1333152-99-0

Chemical Structure| 1333152-99-0

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Product Details of [ 1333152-99-0 ]

CAS No. :1333152-99-0
Formula : C8H7ClN2
M.W : 166.61
SMILES Code : N#CC1=CC(NC)=CC(Cl)=C1
MDL No. :MFCD24619596

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Application In Synthesis of [ 1333152-99-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1333152-99-0 ]

[ 1333152-99-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 327056-73-5 ]
  • [ 74-89-5 ]
  • [ 1333152-99-0 ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate; In dimethyl sulfoxide; at 125℃; for 0.5h;microwave; Example 18 [00362] Synthesis of Intermediate (1)(1)Molecular Weight: 155.56Molecu lar Weight: 166.61[00363] In a 35 mL microwave vial, 3-chloro-5-fluoro benzonitrile (0.5 g, 1 eq.), Methyl amine (0.2 g, 2.0 eq.), K2C03 (1.55 g, 3.5 eq.) was mixed with DMSO (10 mL, 20 Vol). The reaction mixture was stirred at 125 C in microwave for 30 min. Reaction completion was monitored on TLC using ethyl acetate: hexane (5:5) mobile phase. After 30 minutes reaction was completed and worked up. Reaction mixture was brought to room temperature and quenched into the ice-water slurry (100 mL) and compound was extracted in the ethyl acetate (50 mL x 3). Organic layer was washed with brine solution (50 mL x 3) followed by drying using anhydrous sodium sulphate. Organic layer was concentrated under reduced pressure to afford 0.5 g of crude compound. Mass/LCMS: 167.0, NMR: Confirmed.
 

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