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Chemical Structure| 1335054-73-3 Chemical Structure| 1335054-73-3

Structure of 1335054-73-3

Chemical Structure| 1335054-73-3

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Product Details of [ 1335054-73-3 ]

CAS No. :1335054-73-3
Formula : C11H13N3O2
M.W : 219.24
SMILES Code : O=C(C1=C(C)N=C2N=CC(C)=CN21)OCC

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Application In Synthesis of [ 1335054-73-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1335054-73-3 ]

[ 1335054-73-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 50840-23-8 ]
  • [ 84911-18-2 ]
  • [ 1335054-73-3 ]
YieldReaction ConditionsOperation in experiment
23% With sodium hydrogencarbonate; In 1,2-dimethoxyethane; for 36h;Inert atmosphere; Reflux; 2-Amino-5-methylpyrimidine (1.0 g, 8.9 mmol), ethyl-2-bromoacetoacetate(2.3 g, 10.7 mmol) and sodium bicarbonate (1.1 g, 13.3 mmol) were dissolved in 25 mL of 1,2-dimethoxyethane (DME) and heated for 36 h at reflux. The reaction mixture was filtered; solids were collected and washed with CH2Cl2. The filtrate was concentrated in vacuo and the residue was dissolved in CH2Cl2 and washed with 5% acetic acid solution (2x) and brine. The organic phase was collected, dried over Na2SO4, filtered and then concentrated in vacuo. Crude material obtained was purified by silica gel column chromatography with a 25% ethyl acetate : CH2Cl2 solvent system to give 0.457 g (23%) of ethyl 2,6-dimethylimidazo[1,2-a]pyrimidine-3-carboxylate as a light solid. 1H NMR (300 MHz, CDCl3) delta 9.37 (dd, J = 2.4, 1.1 Hz, 1H), 8.53 (d, J = 2.4 Hz, 1H), 2.75 (s, 3H), 4.41 (q, J = 7.1, 7.1, 7.1 Hz, 2H), 2.40 (s, 3H) 1.44 (t, J = 7.1, 7.1 Hz, 3H).
 

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