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Chemical Structure| 1346172-80-2 Chemical Structure| 1346172-80-2

Structure of 1346172-80-2

Chemical Structure| 1346172-80-2

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Product Details of [ 1346172-80-2 ]

CAS No. :1346172-80-2
Formula : C9H9ClN2O3
M.W : 228.63
SMILES Code : O=C(C1(OC2=NC(Cl)=CN=C2)CC1)OC

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Application In Synthesis of [ 1346172-80-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1346172-80-2 ]

[ 1346172-80-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 4774-14-5 ]
  • [ 33689-29-1 ]
  • [ 1346172-80-2 ]
YieldReaction ConditionsOperation in experiment
Step 1. Methyl l-[(6-chloropyrazin-2-yl)oxy1cyclopropanecarboxylateSodium hydride (0.258 g, 60% dispersion in mineral oil, 6.46 mmol) was added to a solution of methyl 1 -hydroxy cyclopropanecarboxylate (0.5 g, 4.31 mmol) in anhydrous DMF (14.4 mL) at 0 C and the mixture was stirred for 30 min. 2,6-Dichloropyrazine (0.642 g, 4.31 mmol) was added and the resulting mixture was allowed to stir at 0 C for additional 1 h before quenched by two drops of water. The reaction mixture was concentrated in vacuo and the residue was applied to silica gel chromatography, eluting with a gradient of ethyl acetate: hexane 5:95 to 50:50 to afford the title compound, which was contaminated with residual DMF. MS APCI: [M + H]+ m/z = 229.0.
 

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