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Chemical Structure| 135002-40-3 Chemical Structure| 135002-40-3

Structure of 135002-40-3

Chemical Structure| 135002-40-3

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Product Details of [ 135002-40-3 ]

CAS No. :135002-40-3
Formula : C20H18N4O2
M.W : 346.38
SMILES Code : O=C(NCC1C=CC=CC=1)C1C=C(C(=O)NCC2C=CC=CC=2)N=CN=1
MDL No. :N/A

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Application In Synthesis of [ 135002-40-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 135002-40-3 ]

[ 135002-40-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 16490-02-1 ]
  • [ 100-46-9 ]
  • [ 135002-40-3 ]
YieldReaction ConditionsOperation in experiment
1.7 g of <strong>[16490-02-1]pyrimidine-4,6-dicarboxylic acid</strong> are suspended in 20 ml of toluene and 2.4 g of thionyl chloride and 0.2 ml of dimethylformamide are added. The mixture is heated to reflux until it is no longer possible to observe any gas evolution (about 3 hours (h)). About 5ml of solvent are distilled off and the mixture is then cooled down to from 0C to 10C and 2.7 g of benzylamine, dissolved in 10 ml of toluene, are added. The solution is slowly heated to room temperature, then stirred at room temperature for 12 hours and evaporated down to dryness. The residue is taken up in 50 ml of methylene chloride and the solution is extracted 3 times by shaking with saturated sodium hydrogen carbonate solution; the organic phase is washed with water, dried with magnesium sulfate and evaporated. The solid is recrystallized from diisopropyl ether. Yield: 2.1 m.p.: 131C to 132C.
 

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