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[ CAS No. 1350643-73-0 ] {[proInfo.proName]}

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Chemical Structure| 1350643-73-0
Chemical Structure| 1350643-73-0
Structure of 1350643-73-0 * Storage: {[proInfo.prStorage]}
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Product Details of [ 1350643-73-0 ]

CAS No. :1350643-73-0 MDL No. :MFCD30747978
Formula : C27H25ClN6O2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 500.99 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 1350643-73-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 1350643-73-0 ]
  • Downstream synthetic route of [ 1350643-73-0 ]

[ 1350643-73-0 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 1350643-73-0 ]
  • [ 1201438-56-3 ]
YieldReaction ConditionsOperation in experiment
93.5%
Stage #1: With hydrogenchloride In ethanol; water at 22 - 35℃; for 1.5 h;
Stage #2: With ammonium hydroxide In ethanol; water
The intermediate (Compound 10) (200 g) was slurried in an ethanol (900 mL; 4.5 vol)/water (300 mL; 1.5 vol) mixture at 22° C. followed by addition of conc. HCl (300 mL; 1.5 vol) and holding for one and half hours at 25-35° C. Addition of HCl resulted in complete dissolution of all solids producing a dark brown solution. Ammonium hydroxide (260 mL) was added adjusting the pH to 8-9. Product seeds of polymorph Form C (0.5 g) (Form A seeds can also be used) were then added and the batch which was held for ten minutes followed by addition of water (3 L; 15 vol) over two hours resulting in crystallization of the product. The batch was held for 3.5 hours at 20-25° C. and then filtered. The cake was washed with water (1 L; 5 vol) followed by heptane (800 mL; 4 vol) and vacuum dried at 52° C. for 23 hours to give 155.5 g (93.5percent) of product with 99.6percent (AUC) purity and 93.8percent ee (chiral HPLC).
Reference: [1] Patent: US2012/184568, 2012, A1, . Location in patent: Page/Page column 83-84
[2] Patent: WO2011/146882, 2011, A1, . Location in patent: Page/Page column 119-120
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