[ CAS No. 135145-34-5 ] {[proInfo.proName]}

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Quality Control of [ 135145-34-5 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 135145-34-5 ]

SDS Specification

Alternatived Products of [ 135145-34-5 ]

Product Details of [ 135145-34-5 ]

CAS No. :	135145-34-5	MDL No. :	MFCD08458908
Formula :	C₈H₉ClO	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	QYUQVBHGBPRDKN-LURJTMIESA-N
M.W :	156.61	Pubchem ID :	6950741
Synonyms :

Safety of [ 135145-34-5 ]

Signal Word:	Warning	Class:
Precautionary Statements:	P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501	UN#:
Hazard Statements:	H302-H315-H319-H335	Packing Group:
GHS Pictogram:

Application In Synthesis of [ 135145-34-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 135145-34-5 ]

[ 135145-34-5 ] Synthesis Path-Downstream 1~7

1
[ 120121-01-9 ]
[ 135145-34-5 ]
[ 120121-01-9 ]

Reference： [1]Tetrahedron Letters,1995,vol. 36,p. 6263 - 6266
[2]Tetrahedron Asymmetry,2001,vol. 12,p. 3147 - 3153
[3]Journal of the American Chemical Society,2014,vol. 136,p. 547 - 549
[4]RSC Advances,2016,vol. 6,p. 21293 - 21301
[5]New Journal of Chemistry,2016,vol. 40,p. 4891 - 4894

2
[ 120121-01-9 ]
[ 135145-34-5 ]

Yield	Reaction Conditions	Operation in experiment
49%	With C45H32I4O6; 1,1,1,3,3,3-hexamethyl-disilazane; In dichloromethane; at -30℃; for 2h;	The racemic alcohol (1s) at -30 C1.0 mmol as a catalyst was dissolved in 5 ml dichloromethane (wherein, R I andn is 2; and pharmaceutically acceptable salts thereof) compound of the formula(2) the addition of 0.01 mol% of potassium and fluoro one equivalent offluoride, a carboxylic acid group and the ion exchange resin 80 mg silylatingagent of formula (5), including (in the formula, R is methyl) wasadded to 0.7 equivalents, and then the mixture was stirred for 1 hour. Filteringthe mixture was concentrated and then to recover the potassium fluoride and theion exchange resin. The residue was purified by flash chromatography (acetone /hexane / triethylamine = 1: 5: 0.025) to give the chiral alcohol; to give the(2s, 46% yield 97% ee, (S) -form).
46%	With potassium fluoride; C46H34I4O6; 1,1,1,3,3,3-hexamethyl-disilazane; In dichloromethane; at -30℃;	At -30C, racemic alcohol (1s) 1.0 mmol was dissolved in 5 ml dichloromethane, the compound of formula 2(wherein, R is I and n is 2; and pharmaceutically acceptable salts) 0.01 mol% as a catalyst and the addition of 0.7 eq., of silylating agent formula (5) (in the formula, R4 is methyl)and 1 equivalent of potassium fluoride and 80 mg of carboxylic acid group ion exchange resin was added and stirred for 1 hour. The mixture was filtered then concentrated to recover potassium fluoride and the ion exchange resin. The residue was purified by flash chromatography (acetone /hexane / triethylamine = 1: 5: 0.025) to give the chiral alcohol (2s, 46% yield 97% ee, (S)-form).

Reference： [1]Patent: KR2015/114445,2015,A .Location in patent: Paragraph 0394; 0395; 0396; 0443
[2]Patent: KR2015/114167,2015,A .Location in patent: Paragraph 0399-0400
[3]Bulletin of the Chemical Society of Japan,1996,vol. 69,p. 1079 - 1085
[4]Journal of the Chemical Society. Perkin transactions I,1999,p. 2397 - 2402
[5]ChemCatChem,2015,vol. 7,p. 4016 - 4020

3
[ 120121-01-9 ]
[ 135145-34-5 ]
[ 120121-01-9 ]
[ 99-02-5 ]

Yield	Reaction Conditions	Operation in experiment
		General procedure: Racemic secondary alcohols (0.25 mmol), catalyst (1.5 mol% of substrate), and KBr (0.02 mmol, 0.0024 g) were added to H2O(1.5 mL). The mixture was stirred for 10 min at room temperature, and then PhI(OAc)2 (0.175 mmol, 0.056 g) was added in four equal parts. The reaction progress was monitored by gas chromatography (GC). After achieving the desired oxidation level, the reaction mixture was heated to 40 ?C. The catalyst was precipitated out of the reaction system, washed with diethyl ether(3× 5 mL), dried in a vacuum, and finally recharged with fresh substrate, additive, and oxidant for the next catalytic cycle. The supernatants separated from the reaction system were extractedwith ether three times. The collected organic phase was driedover sodium sulfate and concentrated in a vacuum. The resultantmixture was purified by column chromatography on silica gel athe stationary phase (petroleum ether/ethyl acetate, 90/10). Enantioselectivitywas determined by a Agilent Technologies 6890NGC system equipped with a 19091G-B213 chiral capillary column(30 m×0.32 mm×0.25 m) with an FID.

Reference： [1]Journal of Molecular Catalysis B: Enzymatic,2012,vol. 83,p. 23 - 28
[2]Tetrahedron Letters,2000,vol. 41,p. 8131 - 8135
[3]Journal of Organic Chemistry,2003,vol. 68,p. 402 - 406
[4]Journal of Organic Chemistry,2003,vol. 68,p. 402 - 406
[5]Organic Letters,2006,vol. 8,p. 5565 - 5567
[6]Catalysis Communications,2011,vol. 15,p. 27 - 31
[7]Green Chemistry,2012,vol. 14,p. 1289 - 1292
[8]Applied Catalysis A: General,2013,vol. 458,p. 1 - 10

4
[ 108-05-4 ]
[ 120121-01-9 ]
[ 136705-69-6 ]
[ 135145-34-5 ]
[ 120121-01-9 ]

Reference： [1]Tetrahedron Asymmetry,2008,vol. 19,p. 1418 - 1423

5
[ 32807-28-6 ]
[ 120121-01-9 ]
[ 135145-34-5 ]
[ 120121-01-9 ]
[ 86728-93-0 ]

Reference： [1]Journal of Organic Chemistry,2009,vol. 74,p. 1730 - 1732

6
[ 120121-01-9 ]
[ 42981-08-8 ]
[ 135145-34-5 ]
[ 120121-01-9 ]
(R)-2-chloro-1-(3,4-dichlorophenyl)ethan-1-ol [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2009,vol. 74,p. 1730 - 1732

7
[ 120121-01-9 ]
[ 135145-34-5 ]
[ 99-02-5 ]

Reference： [1]Journal of Molecular Catalysis B: Enzymatic,2012,vol. 83,p. 23 - 28

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Technical Information

• Alkyl Halide Occurrence • Appel Reaction • Buchwald-Hartwig C-N Bond and C-O Bond Formation Reactions • Chugaev Reaction • Corey-Kim Oxidation • Dess-Martin Oxidation • General Reactivity • Grignard Reaction • Hiyama Cross-Coupling Reaction • Hydride Reductions • Jones Oxidation • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Martin's Sulfurane Dehydrating Reagent • Mitsunobu Reaction • Moffatt Oxidation • Oxidation of Alcohols by DMSO • Preparation of Alcohols • Preparation of Amines • Reactions of Alcohols • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reactions with Organometallic Reagents • Ritter Reaction • Sharpless Olefin Synthesis • Stille Coupling • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Swern Oxidation

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[ 135145-34-5 ]

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[ CAS No. 135145-34-5 ] {[proInfo.proName]}

Quality Control of [ 135145-34-5 ]

Related Doc. of [ 135145-34-5 ]

Product Details of [ 135145-34-5 ]

Safety of [ 135145-34-5 ]

Application In Synthesis of [ 135145-34-5 ]

[ 135145-34-5 ] Synthesis Path-Downstream 1~7

Technical Information

Related Functional Groups of [ 135145-34-5 ]

Aryls

Chlorides

Alcohols

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 135145-34-5 ]