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[ CAS No. 135273-01-7 ]

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Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 135273-01-7
Chemical Structure| 135273-01-7
Structure of 135273-01-7 *Storage: {[proInfo.prStorage]}

Quality Control of [ 135273-01-7 ]

Related Doc. of [ 135273-01-7 ]

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Product Details of [ 135273-01-7 ]

CAS No. :135273-01-7MDL No. :MFCD00237447
Formula : C36H32N2O8S2 Boiling Point : -
Linear Structure Formula :-InChI Key :N/A
M.W :684.78Pubchem ID :14389776
Synonyms :

Computed Properties of [ 135273-01-7 ]

TPSA : 202 H-Bond Acceptor Count : 10
XLogP3 : 5.8 H-Bond Donor Count : 4
SP3 : 0.22 Rotatable Bond Count : 15

Safety of [ 135273-01-7 ]

Signal Word:WarningClassN/A
Precautionary Statements:P261-P305+P351+P338UN#:N/A
Hazard Statements:H302-H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 135273-01-7 ]

  • Upstream synthesis route of [ 135273-01-7 ]
  • Downstream synthetic route of [ 135273-01-7 ]

[ 135273-01-7 ] Synthesis Path-Upstream   1~5

  • 1
  • [ 56-89-3 ]
  • [ 28920-43-6 ]
  • [ 135273-01-7 ]
YieldReaction ConditionsOperation in experiment
98% With sodium carbonate In 1,4-dioxane; water at 10 - 20℃; for 2.00 h; Sodium carbonate (4.6 g, 43.6 mmol) and L-cystine (5.0 g, 20.8 mmol) were dissolved in water (200 mL). The resulting solution was cooled to 10° C. FmocCl (11.85 g, 45.8 mmol) was dissolved in dioxane (80 mL), and the resulting solution was added dropwise to the aqueous solution of L-cystine. The solution was stirred for 2 h at 10° C. and allowed to gradually warm to room temperature. A thick white precipitate was obtained that was filtered onto a sintered glass funnel. The product was triturated with diethyl ether (50 mL) and dried in vacuuo for 2 d. N,N'-Bis(Fmoc)-L-cystine (14.0 g, 98percent yield) was obtained as a white powder.
Reference: [1] Patent: US2007/37963, 2007, A1. Location in patent: Page/Page column 11-12; Figure 4
  • 2
  • [ 56-89-3 ]
  • [ 82911-69-1 ]
  • [ 135273-01-7 ]
YieldReaction ConditionsOperation in experiment
94% With sodium carbonate In water; acetone at 50℃; General procedure: Procedure adapted from that of Agan et al[28]. 407 mg Na2CO3 (3.82 mmol) was dissolved in 30 mL distilled water with stirring. 35 mL acetone was then added followed by 1.91 mmol L-cystine or L-selenocystine. The temperature of the reaction was brought to 50 °C and 1.93g (5.73 mmol) Fmoc-OSu was added in portions over 5 minutes. Heating was removed and the reaction was allowed to progress overnight. At the end of this time, 40 mL 1 HCl was added followed by 50 mL EtOAc. Following vigorous shaking, the layers were separated, and the organic portionwas dried over MgSO4 and concentrated in vacuo to afford the crude bis N-Fmoc dichalcogenide which was purified by recrystallization from CHCl3.
Reference: [1] Protein and Peptide Letters, 2014, vol. 21, # 12, p. 1257 - 1264
  • 3
  • [ 86060-81-3 ]
  • [ 135273-01-7 ]
Reference: [1] Chemical Communications, 2014, vol. 50, # 71, p. 10295 - 10298
  • 4
  • [ 103213-32-7 ]
  • [ 135273-01-7 ]
Reference: [1] Biopolymers, 2017, vol. 108, # 2,
  • 5
  • [ 135248-89-4 ]
  • [ 135273-01-7 ]
Reference: [1] New Journal of Chemistry, 2015, vol. 39, # 10, p. 7750 - 7753
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