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[ CAS No. 135292-35-2 ] {[proInfo.proName]}

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3d Animation Molecule Structure of 135292-35-2
Chemical Structure| 135292-35-2
Chemical Structure| 135292-35-2
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Product Details of [ 135292-35-2 ]

CAS No. :135292-35-2 MDL No. :MFCD20483333
Formula : C6H7ClN2O Boiling Point : -
Linear Structure Formula :- InChI Key :RCJNDDNXUYCUOY-UHFFFAOYSA-N
M.W : 158.59 Pubchem ID :11051933
Synonyms :

Safety of [ 135292-35-2 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 135292-35-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 135292-35-2 ]

[ 135292-35-2 ] Synthesis Path-Downstream   1~25

  • 1
  • [ 135292-35-2 ]
  • [ 135292-31-8 ]
  • [ 135292-37-4 ]
  • 2
  • [ 135292-35-2 ]
  • phenyl 2,3-dideoxy-1-thio-D-glycero-pentofuranoside [ No CAS ]
  • phenyl 2,3-dideoxy-5-O-(4-methoxy-5-methyl-2-pyrimidyl)-1-thio-D-glycero-pentofuranoside [ No CAS ]
  • 3
  • [ 135292-35-2 ]
  • ((2R,3S,5R)-3-Fluoro-5-phenylsulfanyl-tetrahydro-furan-2-yl)-methanol [ No CAS ]
  • [ 155446-91-6 ]
  • 4
  • [ 135292-35-2 ]
  • ((2S,3S,5R)-3-Azido-5-phenylsulfanyl-tetrahydro-furan-2-yl)-methanol [ No CAS ]
  • [ 155446-90-5 ]
  • 5
  • [ 135292-35-2 ]
  • ((2S,3S,5R)-3-Azido-5-phenylsulfanyl-tetrahydro-furan-2-yl)-methanol [ No CAS ]
  • [ 155446-90-5 ]
  • 4-Methoxy-5-methyl-2-((2S,5R)-5-phenylsulfanyl-2,5-dihydro-furan-2-ylmethoxy)-pyrimidine [ No CAS ]
  • 6
  • [ 135292-35-2 ]
  • [ 204636-93-1 ]
  • 4-Methoxy-5-methyl-2-((S)-5-phenylselanyl-tetrahydro-furan-2-ylmethoxy)-pyrimidine [ No CAS ]
  • 7
  • [ 135292-35-2 ]
  • [ 220222-88-8 ]
  • [ 220222-89-9 ]
  • 8
  • [ 135292-35-2 ]
  • 1-((2S,3R)-2-Hydroxymethyl-2,3-dihydro-furan-3-yl)-4-methoxy-5-methyl-1H-pyrimidin-2-one [ No CAS ]
  • 9
  • [ 135292-35-2 ]
  • [ 3416-05-5 ]
  • 10
  • [ 135292-35-2 ]
  • [ 30516-87-1 ]
  • 11
  • [ 135292-35-2 ]
  • [ 155446-85-8 ]
  • 12
  • [ 135292-35-2 ]
  • (S)-5-(4-Methoxy-5-methyl-pyrimidin-2-yloxymethyl)-tetrahydro-furan-2-ol [ No CAS ]
  • 13
  • [ 135292-35-2 ]
  • [ 145688-92-2 ]
  • 14
  • [ 135292-35-2 ]
  • [ 108441-68-5 ]
  • 15
  • [ 135292-35-2 ]
  • C11H15N2O3(1+)*BF4(1-) [ No CAS ]
  • 16
  • [ 135292-35-2 ]
  • C11H14FN2O3(1+)*BF4(1-) [ No CAS ]
  • 17
  • [ 135292-35-2 ]
  • C11H14N5O3(1+)*BF4(1-) [ No CAS ]
  • 18
  • [ 135292-35-2 ]
  • [ 25526-93-6 ]
YieldReaction ConditionsOperation in experiment
100% General procedure: title compound (81%) as an orange solid, which was used without further purification.LRMS (m/z): 163 (M+1)+.1H-NMR δ (CDCl3): 4.11 (s, 3H), 8.20 (d, 1 H)
85% With sodium; at 20.0℃; General procedure: sodium (450 mg, 19 mmol) in methanol (20 mL) was added a solution of 2,4-dichloro-5-fluoropyrimidine (3.25 g, 19 mmol) in methanol (10mL). The reaction mixture was stirred at room temperature overnight before being partitioned between water and diethyl ether. The organic phase was separated, washed with brine and evaporated to dryness to give the title compound as an orange oil (80%), which was used in the next step without further purification.1H-NMR δ (400 MHz, CDCl3): 4.11 (s, 3H), 8.20 (s, 1 H).
  • 20
  • [ 67-56-1 ]
  • [ 1780-31-0 ]
  • [ 124-41-4 ]
  • [ 135292-35-2 ]
YieldReaction ConditionsOperation in experiment
74% at 20.0℃; for 12.0h; To a solution of 2,4-dichloro-5-methylpyrimidine (12.8 g, 80 mmol, 1 equiv) in MeOH (30 mL) was added NaOMe (5 mol/L in MeOH, 14.8 mL, 74 mmol, 0.9 equiv) dropwise. The reaction mixture was stirred at room temperature for 12 hours and concentrated. The residue was charged with H2O (30 mL) and extracted with DCM (3 * 80 mL). The combined organic phase were washed with brine (30 mL), dried over anhydrous Na2S04 and concentrated in vacuo. The residue was purified by flash column chromatography on silica gel (eluted with PE/EtOAc = 100/1) to afford the title compound 2-chloro-4- methoxy-5-methylpyrimidine as a white solid (9.3 g, 74% yield). LC-MS: m/z 159.1 (M+H)+.
62% for 20.0h; 5.4M Sodium methoxide in MeOH (1.14 mL) was added to a suspension of 2,4-dichloro-5-methylpyrimidine (1.0 g, 6.1 mmol) in MeOH (20 mL) and the reaction stirred for 20 h. The mixture was concentrated and the residue partitioned between EtOAc and water. The aqueous layer was extracted into EtOAc (x3), the combined organics washed with brine, dried (MgSO4) and concentrated. The residue was purified by Biotage Isolera chromatography (silica gel, eluting with 0-50% EtOAc in heptane to yield 600 mg (62% yield) of the title compound as a white solid. 1H NMR (500 MHz, CDCl3) d 8.10 (s, 1H), 4.03 (s, 3H), 2.12 (d, J = 0.7 Hz, 3H). LCMS (Analytical Method D) Rt= 1.00, MS (ESIpos): m/z= 158.9 [M+H]+.
  • 21
  • [ 67-56-1 ]
  • [ 201230-82-2 ]
  • [ 135292-35-2 ]
  • methyl 4-methoxy-5-methylpyrimidine-2-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
47% With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine; In N,N-dimethyl-formamide; at 120.0℃; under 2585.81 Torr; for 48.0h; To a solution of <strong>[135292-35-2]2-chloro-4-methoxy-5-methylpyrimidine</strong> (9.3 g, 58.6 mmol, 1 equiv) in MeOH (220 mL) and DMF (45 mL) were added Pd(dppf)Cl2 (2.1 g, 2.9 mmol, 0.05 equiv) and triethylamine (17.8 g, 175.8 mmol, 3 equiv). The mixture was degassed and refilled with CO three times and then stirred at l20C under CO (50 Psi) for 48 hours. The reaction mixture was cooled to room temperature and concentrated in vacuo. The residue was purified by silica gel chromatography (eluted with PE/EtOAc = 10/1) to afford the title compound methyl 6-(trifluoromethoxy)picolinate as yellow oil (5.0 g, 47% yield). LC-MS : m/z 183.1 (M+H) +
  • 22
  • [ 135292-35-2 ]
  • 4-methoxy-5-methylpyrimidine-2-carboxylic acid [ No CAS ]
  • 23
  • [ 135292-35-2 ]
  • 2‐hydrazinyl‐4‐methoxy‐5‐methylpyrimidine [ No CAS ]
YieldReaction ConditionsOperation in experiment
34% With hydrazine hydrate; In ethanol; at 60.0℃; for 4.0h; Hydrazine hydrate (768 µL, 15.8 mmol) was added to a solution of 2- chloro-4-methoxy-5-methylpyrimidine (250 mg, 1.6 mmol) (Intermediate 87) in EtOH (4 mL) and the reaction heated to 60 C for 4 h. The reaction was cooled and allowed to stand at room temperature for 18 h. The solid material was collected by filtration, washed with EtOH and dried affording 110 mg (34% yield) of the title compound as a white solid. LCMS (Analytical Method D) Rt= solvent front, MS (ESIpos): m/z= 154.90 [M+H]+.
  • 24
  • [ 135292-35-2 ]
  • 7‐methoxy‐6‐methyl‐2H,3H‐[1,2,4]triazolo[4,3‐a]pyrimidin‐3‐one [ No CAS ]
  • 25
  • (R)-6-amino-4-isopropyl-1,3-dimethyl-3,4-dihydroquinoxalin-2(1H)-one [ No CAS ]
  • [ 135292-35-2 ]
  • C19H25N5O2 [ No CAS ]
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