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Chemical Structure| 1353677-48-1 Chemical Structure| 1353677-48-1

Structure of 1353677-48-1

Chemical Structure| 1353677-48-1

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Product Details of [ 1353677-48-1 ]

CAS No. :1353677-48-1
Formula : C11H15ClN2O2
M.W : 242.70
SMILES Code : O=C(OC(C)(C)C)NC1=C(C)C=CN=C1Cl

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Application In Synthesis of [ 1353677-48-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1353677-48-1 ]

[ 1353677-48-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 24424-99-5 ]
  • [ 133627-45-9 ]
  • [ 1353677-48-1 ]
YieldReaction ConditionsOperation in experiment
With sodium hexamethyldisilazane; In tetrahydrofuran; at 0 - 20℃; 62d) tert-butyl (2-chloro-4-methylpyridin-3-yl)carbamate To a mixture of <strong>[133627-45-9]2-chloro-4-methylpyridin-3-amine</strong> (0.75 g) and di-tert-butyl dicarbonate (1.3 mL) in THF (10 mL) was added dropwise hexamethyldisilazane sodium salt (2M in THF, 6.1 mL) at 0 C. The mixture was stirred at 0 C. to room temperature overnight. The mixture was neutralized with 1N HClaq., and the mixture was extracted with AcOEt. The organic layer was dried over MgSO4, and concentrated in vacuo to give tert-butyl (2-chloro-4-methylpyridin-3-yl)carbamate (1.2 g) as an orange solid.1H NMR (300 MHz, DMSO-d6) delta 1.34 (9H, brs), 2.15 (3H, s), 7.23 (1H, d, J=4.9 Hz), 8.05 (1H, d, J=4.9 Hz), 8.79 (1H, brs).
 

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