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Chemical Structure| 1354822-44-8 Chemical Structure| 1354822-44-8

Structure of 1354822-44-8

Chemical Structure| 1354822-44-8

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Product Details of [ 1354822-44-8 ]

CAS No. :1354822-44-8
Formula : C16H21N3O2
M.W : 287.36
SMILES Code : O=C(C1=C2C(N(C(C)C)N=C2C)=NC(C3CC3)=C1)OCC

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Application In Synthesis of [ 1354822-44-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1354822-44-8 ]

[ 1354822-44-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 21080-80-8 ]
  • [ 1124-16-9 ]
  • [ 1354822-44-8 ]
YieldReaction ConditionsOperation in experiment
71% In benzene; at 65℃; for 6.0h; Intermediate 33Ethyl 6-cyclopropyl-3-methyl-l-(l-methylethyl)-lH-pyrazolo[3,4-6]pyridine-4- carbox lateA solution of ethyl 4-cyclopropyl-2,4-dioxobutanoate (700 mg, 3.76 mmol), 3- methyl-l-(l-methylethyl)-lH-pyrazol-5 -amine (523 mg, 3.76 mmol) and benzene (20 mL) were heated at 65 °C for 6 hr, and then allowed to cool to room temperature for 2 d. The solvent was removed under reduced pressure and the residue purified via silica gel chromatography (eluent: 0 to 25percent EtOAc:Hex). The final product was collected as 0.77 g (71percent). LCMS E-S (M+H) = 288.0. 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 1.04 - 1.11 (m, 2 H), 1.13 - 1.20 (m, 4 H), 1.47 (t, J=7.20 Hz, 6 H), 1.55 (d, J=6.82 Hz, 12 H), 2.16 - 2.25 (m, 2 H), 2.68 (s, 6 H), 4.49 (q, J=7.07 Hz, 4 H), 5.20 (spt, J=6.78 Hz, 2 H), 7.41 (s, 1 H).
 

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