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Chemical Structure| 1356953-52-0 Chemical Structure| 1356953-52-0

Structure of 1356953-52-0

Chemical Structure| 1356953-52-0

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Product Details of [ 1356953-52-0 ]

CAS No. :1356953-52-0
Formula : C16H24N4O4
M.W : 336.39
SMILES Code : O=C(OC(C)(C)C)N(C)C1CN(C2=NC=C([N+]([O-])=O)C=C2)CCC1

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Application In Synthesis of [ 1356953-52-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1356953-52-0 ]

[ 1356953-52-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 4548-45-2 ]
  • [ 172478-01-2 ]
  • [ 1356953-52-0 ]
YieldReaction ConditionsOperation in experiment
99% With triethylamine; In tetrahydrofuran; at 20℃; for 16h; Example 1024tert-buiy methyl(l -(5-nitropyridin-2-yl)piperidin-3-yl)carbamateTo a solution of tert-buty methyl(piperidin-3-yl)carbamate (1 .00 g, 4.67 mmol) in THF (25 mL) was added triethylamine (0.70 mL, 5.0 mmol) and 2-chloro-5-nitropyridine (500 mg, 3.1 mmol). The reaction mixture was then stirred at room temperature for 16 h, diluted with a saturated NaHC03 solution and extracted with ethyl acetate. The combined organic layers were dried over anhydrous sodium sulfate and concentrated. Purification by column chromatography (silica, ethyl acetate/hexanes) afforded the desired product (1.03 g, 99%) as a yellow solid. ESI MS m/z 337 [Ci6H24 404 + H]+
 

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