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Chemical Structure| 1357564-25-0 Chemical Structure| 1357564-25-0

Structure of 1357564-25-0

Chemical Structure| 1357564-25-0

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Product Details of [ 1357564-25-0 ]

CAS No. :1357564-25-0
Formula : C13H11BrFNO2
M.W : 312.13
SMILES Code : OC(C1=NC(Br)=CC=C1)C2=CC=C(F)C(OC)=C2

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Application In Synthesis of [ 1357564-25-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1357564-25-0 ]

[ 1357564-25-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 34160-40-2 ]
  • [ 103291-07-2 ]
  • [ 1357564-25-0 ]
YieldReaction ConditionsOperation in experiment
To a solution of <strong>[103291-07-2]5-bromo-2-fluoroanisole</strong> (200 mg, 0.98 mmol, 1 equiv) in anhydrous THF was added granules of magnesium (24 mg, 0.98 mmol, 1 equiv) under nitrogen. The mixture was heated to 60 C for 2 h. After reaching room temperature, 6-bromopyridin-2-yl carboxaldehyde (182 mg, 0.98 mmol, 1 equiv) was added and the reaction mixture was heated to 80 C and stirred overnight at 80 C. The reaction was cooled to room temperature, quenched with brine and the aqueous layer was extracted with ethyl acetate. The combined organic layers were dried over sodium sulfate, filtered and concentrated to dryness under vacuum. The product was used in the next step without further purification. C13H11BrFNO2; MW 312.
 

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