[ CAS No. 136316-07-9 ] {[proInfo.proName]}

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Quality Control of [ 136316-07-9 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 136316-07-9 ]

Product Details of [ 136316-07-9 ]

CAS No. :	136316-07-9	MDL No. :	MFCD10687401
Formula :	C₁₃H₁₆N₂O₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	-
M.W :	232.28	Pubchem ID :	-
Synonyms :

Safety of [ 136316-07-9 ]

Signal Word:		Class:
Precautionary Statements:		UN#:
Hazard Statements:		Packing Group:

Application In Synthesis of [ 136316-07-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 136316-07-9 ]

[ 136316-07-9 ] Synthesis Path-Downstream 1~12

1
[ 67-56-1 ]
[ 41505-84-4 ]
[ 156632-37-0 ]
[ 156632-36-9 ]
[ 136316-07-9 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium hydroxide; tert-butylhypochlorite; triethylamine 1.) CH₂Cl₂, -78 deg C, 2.) H₂O, 70 deg C, 2 h; Multistep reaction. Yields of byproduct given;

Reference： [1]Bascop, Sophie-Isabelle; Sapi, Janos; Laronze, Jean-Yves; Levy, Jean [Heterocycles, 1994, vol. 38, # 4, p. 725 - 732]

2
[ 41505-84-4 ]
[ 156632-37-0 ]
[ 156632-36-9 ]
[ 136316-07-9 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium hydroxide; tert-butylhypochlorite; triethylamine 1.) CH₂Cl₂, -78 deg C, 2.) CH₃OH, H₂O, 70 deg C, 2 h; Multistep reaction. Yields of byproduct given;

Reference： [1]Bascop, Sophie-Isabelle; Sapi, Janos; Laronze, Jean-Yves; Levy, Jean [Heterocycles, 1994, vol. 38, # 4, p. 725 - 732]

3
[ 17012-21-4 ]
[ 136316-07-9 ]

Reference： [1]Organic Letters,2005,vol. 7,p. 3287 - 3289
[2]Organic Letters,2005,vol. 7,p. 3287 - 3289

4
[ 122684-33-7 ]
[ 136316-07-9 ]

Reference： [1]Organic Letters,2005,vol. 7,p. 3287 - 3289
[2]Organic Letters,2005,vol. 7,p. 3287 - 3289

5
[ 18437-68-8 ]
[ 136316-07-9 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 11 steps 1.1: t-BuLi / pentane; diethyl ether / 3 h / -20 °C 1.2: 86 percent / 1,2-diiodoethane / pentane; diethyl ether / 16 h / -78 - 20 °C 2.1: 89 percent / CF₃COOH / CH₂Cl₂ / 2 h / 20 °C 3.1: 94 percent / ZnCl₂; NaCNBH₃ / CH₂Cl₂ / 2 h / Heating 4.1: 94 percent / Et₃N / benzene / 2 h 5.1: 96 percent / DBU / tetrahydrofuran / 16 h / Heating 6.1: m-CPBA / CH₂Cl₂ / 0.75 h / 0 °C 7.1: 286 mg / toluene / 72 h / Heating 8.1: 68 percent / PPh₃; DEAD; diphenylphosphoryl azide / tetrahydrofuran / 24 h / 20 °C 9.1: tristrimethylsilane; AIBN / benzene / 5 h / Heating 10.1: 123 mg / NaCNBH₃ / acetonitrile / 0.25 h / 20 °C 11.1: 87 percent / NH₃; Na / tetrahydrofuran / 0.2 h / -50 °C
	Multi-step reaction with 9 steps 1.1: t-BuLi / pentane; diethyl ether / 3 h / -20 °C 1.2: 86 percent / 1,2-diiodoethane / pentane; diethyl ether / 16 h / -78 - 20 °C 2.1: 89 percent / CF₃COOH / CH₂Cl₂ / 2 h / 20 °C 3.1: 94 percent / ZnCl₂; NaCNBH₃ / CH₂Cl₂ / 2 h / Heating 4.1: 94 percent / Et₃N / benzene / 2 h 5.1: 83 percent / LiCl; NaBH₄ / tetrahydrofuran; ethanol / 16 h / 20 °C 6.1: 68 percent / PPh₃; DEAD; diphenylphosphoryl azide / tetrahydrofuran / 24 h / 20 °C 7.1: tristrimethylsilane; AIBN / benzene / 5 h / Heating 8.1: 123 mg / NaCNBH₃ / acetonitrile / 0.25 h / 20 °C 9.1: 87 percent / NH₃; Na / tetrahydrofuran / 0.2 h / -50 °C
	Multi-step reaction with 12 steps 1.1: t-BuLi / diethyl ether 1.2: 86 percent / ICH₂CH₂I / diethyl ether / -78 - 20 °C 2.1: 89 percent / TFA / CH₂Cl₂ / 0 - 20 °C 3.1: 95 percent / ZnCl₂; NaCNBH₃ / methanol / 2 h / Heating 4.1: Et₃N / benzene / Heating 5.1: 96 percent / DBU / tetrahydrofuran / Heating 6.1: 55 percent / DIBAL-H / toluene / -78 °C 7.1: m-CPBA 8.1: toluene / Heating 9.1: 68 percent / (PhO)2PON₃; Ph₃P; DEAD / 20 °C 10.1: tris(trimethylsilyl)silane; AIBN / benzene / Heating 11.1: NaCNBH₃

Multi-step reaction with 9 steps 1.1: t-BuLi / diethyl ether 1.2: 86 percent / ICH₂CH₂I / diethyl ether / -78 - 20 °C 2.1: 89 percent / TFA / CH₂Cl₂ / 0 - 20 °C 3.1: 95 percent / ZnCl₂; NaCNBH₃ / methanol / 2 h / Heating 4.1: Et₃N / benzene / Heating 5.1: DIBAL-H / toluene / -78 °C 6.1: 68 percent / (PhO)2PON₃; Ph₃P; DEAD / 20 °C 7.1: tris(trimethylsilyl)silane; AIBN / benzene / Heating 8.1: NaCNBH₃

Reference： [1]Lizos, Dimitrios E.; Murphy, John A. [Organic and Biomolecular Chemistry, 2003, vol. 1, # 1, p. 117 - 122]
[2]Lizos, Dimitrios E.; Murphy, John A. [Organic and Biomolecular Chemistry, 2003, vol. 1, # 1, p. 117 - 122]
[3]Lizos; Tripoli; Murphy [Chemical Communications, 2001, # 24, p. 2732 - 2733]
[4]Lizos; Tripoli; Murphy [Chemical Communications, 2001, # 24, p. 2732 - 2733]

6
[ 157496-75-8 ]
[ 136316-07-9 ]

Reference： [1]Organic and Biomolecular Chemistry,2003,vol. 1,p. 117 - 122
[2]Organic and Biomolecular Chemistry,2003,vol. 1,p. 117 - 122
[3]Chemical Communications,2001,p. 2732 - 2733
[4]Chemical Communications,2001,p. 2732 - 2733

7
[ 5367-32-8 ]
[ 136316-07-9 ]

Reference： [1]Journal of Organic Chemistry,2001,vol. 66,p. 8447 - 8453
[2]Journal of Organic Chemistry,2001,vol. 66,p. 8447 - 8453

8
[ 20876-29-3 ]
[ 136316-07-9 ]

Reference： [1]Journal of Organic Chemistry,2001,vol. 66,p. 8447 - 8453
[2]Journal of Organic Chemistry,2001,vol. 66,p. 8447 - 8453

9
[ 41505-84-4 ]
[ 136316-07-9 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 1.) t-BuOCl, Et₃N, 2.) NaOH / 1.) CH₂Cl₂, -78 deg C, 2.) H₂O, 70 deg C, 2 h 2: NaOMe / methanol / 48 h / Heating 3: p-TsOH, H₂O / toluene / 3 h / Heating
	Multi-step reaction with 2 steps 1: 1.) t-BuOCl, Et₃N, 2.) NaOH / 1.) CH₂Cl₂, -78 deg C, 2.) H₂O, 70 deg C, 2 h 2: p-TsOH, H₂O / toluene / 3 h / Heating

Reference： [1]Bascop, Sophie-Isabelle; Sapi, Janos; Laronze, Jean-Yves; Levy, Jean [Heterocycles, 1994, vol. 38, # 4, p. 725 - 732]
[2]Bascop, Sophie-Isabelle; Sapi, Janos; Laronze, Jean-Yves; Levy, Jean [Heterocycles, 1994, vol. 38, # 4, p. 725 - 732]

10
[ 20315-68-8 ]
[ 136316-07-9 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 1.) NaBH₃CN, 2.) N-methylmorpholine / 1.) H₂O, 2.) THF, reflux, 12 h 2: 1.) NBS, AcOH, 2.) H₂, AcOH, NaOAc / 2.) 5percent Pd/C / 1.) THF, H₂O, -5 deg C, 2.) MeOH, 25 deg C, 12 h

Reference： [1]Pellegrini; Strassler; Weber; Borschberg [Tetrahedron Asymmetry, 1994, vol. 5, # 10, p. 1979 - 1992]

11
[ 51814-19-8 ]
[ 136316-07-9 ]

Reference： [1]Journal of the Chemical Society. Chemical communications,1992,p. 1767 - 1769
[2]Journal of the Chemical Society. Chemical communications,1992,p. 1767 - 1769

12
[ 27387-23-1 ]
[ 136316-07-9 ]

Reference： [1]Organic and Biomolecular Chemistry,2012,vol. 10,p. 6404 - 6409

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Code	Phrase
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P304	IF INHALED:
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P321
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P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
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P378
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P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
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P401
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H201	Explosive; mass explosion hazard
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H231	May react explosively even in the absence of air at elevated pressure and/or temperature
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H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
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H310	Fatal in contact with skin
H311	Toxic in contact with skin
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H316	Causes mild skin irritation
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H401	Toxic to aquatic life
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H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 136316-07-9 ] {[proInfo.proName]}

Quality Control of [ 136316-07-9 ]

Related Doc. of [ 136316-07-9 ]

Product Details of [ 136316-07-9 ]

Safety of [ 136316-07-9 ]

Application In Synthesis of [ 136316-07-9 ]

[ 136316-07-9 ] Synthesis Path-Downstream 1~12

Precautionary Statements-General

Prevention

Response

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Physical hazards

Health hazards

Environmental hazards

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