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Chemical Structure| 1366664-75-6 Chemical Structure| 1366664-75-6

Structure of 1366664-75-6

Chemical Structure| 1366664-75-6

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Product Details of [ 1366664-75-6 ]

CAS No. :1366664-75-6
Formula : C10H10N2O
M.W : 174.20
SMILES Code : N#CC1C=CC(OCC2CC2)=CN=1
MDL No. :N/A

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Application In Synthesis of [ 1366664-75-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1366664-75-6 ]

[ 1366664-75-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 327056-62-2 ]
  • [ 2516-33-8 ]
  • [ 1366664-75-6 ]
YieldReaction ConditionsOperation in experiment
To a mixture of cyclopropylmethanol (6.26 g, 86.8 mmol) in DMF (300 mL) was added NaH (3.60 g, 90.1 mmol, 60% purity) at 0 C and stirred 1 h. <strong>[327056-62-2]5-fluoropicolinonitrile</strong> (10 g, 81.9 mmol) was added at 0 C and stirred for 1 h. Then the mixture was stirred at 20 C for 1 h. The mixture was poured into saturated NTriCl. (0694) The aqueous phase was extracted with EtOAc. The combined organic layers were concentrated to give 5-(cyclopropylmethoxy)picolinonitrile (10.20 g, 55.6 mmol, 67.91% yield, 94.99% purity) which was used directly to next step.
 

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