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Chemical Structure| 1369855-94-6 Chemical Structure| 1369855-94-6

Structure of 1369855-94-6

Chemical Structure| 1369855-94-6

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Product Details of [ 1369855-94-6 ]

CAS No. :1369855-94-6
Formula : C13H19BrO
M.W : 271.19
SMILES Code : CC(OC1=CC=C(Br)C=C1C(C)(C)C)C
MDL No. :MFCD28356571

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Application In Synthesis of [ 1369855-94-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1369855-94-6 ]

[ 1369855-94-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 75-30-9 ]
  • [ 10323-39-4 ]
  • [ 1369855-94-6 ]
YieldReaction ConditionsOperation in experiment
Step 1 : 4-bromo-2-(tert-butyl)- 1-isopropoxybenzene:A solution of <strong>[10323-39-4]4-bromo-2-(tert-butyl)phenol</strong> (10 g, 43.6 mmol) in DMF (50 ml) was cooled to 0 C. NaH (60 % in mineral oil, 3.49 g, 87 mmol) was added slowly. After 30 min, 2- iodopropane (13.07 ml, 131 mmol) was added. Further DMF (40 ml) was added to mobilise the mixture, and it was stirred at RT for 18h. The mixture was partitioned between EtOAc and water. The aqueous layer was extracted with EtOAc, and the combined organic extracts were washed with water, dried (MgS04) and concentrated in vacuo to afford the title compound as a yellow liquid (12.35 g, >100%). Used without further purification.1H NMR (500 MHz, CDCI3): 7.35-7.34 (1 H, d), 7.24-7.22 (1 H, dd), 6.71 -6.69 (1 H, d), 4.63-4.58 (1 H, sept), 1 .38-1 .37 (6H, d), 1 .36 (9H, s).
 

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