Structure of 13731-98-1
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
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The Influence Of Cellulose On The Properties Of Methacrylic Polymers For Dental Applications
Joanna Taczała - Warga ;
Abstract: Acrylic dentures are considered resistant to falls and occlusal forces. The problem appears when the denture plate thickness is reduced. This is the case when the patient requires partial prosthetic reconstruction with a skeletal denture in which a single incisal tooth appears. It is assumed that the frame denture should only be replaced after approx. 4 years, while patients report the need for repair after only a few months. The presence of a metal skeleton significantly reduces the space for acrylic. Therefore, there is a need to modify selected acrylic properties and the bond strength between two acrylics. From the analysis of the available literature, it is possible to identify many compounds used to improve prosthetic acrylic strength. However, considering that nowadays, science is striving to use environmentally friendly biomaterials, it is worth focusing on cellulose. The possibility of using cellulose in the micro size allows it to be used as a filler when there is little space for acrylic. However, due to cellulose's structure, using pure cellulose will not lead to the formation of chemical bonds with methacrylic polymers. Therefore, it is necessary to modify the cellulose surface. Another aspect is the problem with the strength of the connection between acrylic plastics. The researchers tried to solve this problem by making retention catches, mechanically expanding the surface, and wiping the tooth surface with selected chemical reagents. Unfortunately, when trying to choose the best method, various measurement methods used in numerous research make it impossible to compare the results objectively. Therefore, there is a need to standardize the research and indicate the methods that significantly impact the connection between acrylics. Based on the collected information, the following objectives of the study were formulated: • Development of a functional material with increased strength by changing the properties of a cellulose-modified methacrylic polymer. • Improving the bond strength between two methacrylic polymers by modifying the surface. Pure cellulose and modified with two silanes (3-methacryloxypropyl) methyldimethoxysilane (MPMS) and octyltriethoxysilane (OTES)) was added to acrylic in the amount of 0.5, 1.0, and 1.5 g. The most significant effect on the improvement of flexural strength was shown by samples with MPMS cellulose in the amount of 0.5 grams. In this case, the increase in strength was almost 6%. Observations of the breakthroughs also revealed that OTES changed the nature of cellulose and facilitated its better dispersion. However, it was MPMS that, despite worse dispersion, made it possible to increase the strength of the material. The modified cellulose and composite samples produced in this way were additionally subjected to detailed analysis. Shifts in characteristic peaks in the FTIR spectra confirmed cellulose modification. The observed shift in the DSC plot may suggest that the addition of modified cellulose acted as a plasticizer for the dental acrylic resin, which resulted in a change in the glass transition temperature value. On the other hand, the inclusion of functional groups from MPMS in PMMA allowed for covalent bonding of the filler and the polymer matrix, which improved the thermal stability of the tested material in TGA tests. The obtained maximum values of stresses and deformations in the simulation of the influence of the curvature of the prosthesis plate and the retention abutment did not differ significantly. In the case of the T-shaped and round hitch, additional stresses appeared on their top, but their values oscillated around 4 MPa. Therefore, it can be considered that the hook does not improve the connection between the materials. The influence of the grooving configuration was analyzed for shape, groove distribution, and force application angle. Two types of grooves were made - parallel and cross. The parameters that obtained the lowest values of stresses and deformations were mapped on actual samples and compared with the cross configuration and the situation where no mechanical modification was applied. The strength of samples with modification increased by almost 57%. In addition, gradual cracking was observed in the case of parallel grooves. The selected grooving parameters were compared with other methods of mechanical surface expanding. The prepared samples were subjected to shear and tensile tests. Additionally, all samples were divided into three groups according to the influence of the oral environment. The noticeably most significant increase in the strength of the connection was achieved by cutting the glaze layer with a carbide milling cutter on both sides. The highest values were obtained with this method in almost all tests. Two-way milling made it possible to increase the bond strength by up to 200% in the case of dry samples. For the research on improving the bond strength, a group of seven reagents was distinguished, consisting of products characterized by functional groups that could react with the polymer and a second group that could act with the surface of the modified cellulose. All reagents were mixed with the composite components, and FTIR spectra were analyzed. The shift of the peaks corresponding to the Si-O bond indicated a favorable modification. Therefore, it was decided to test the selected chemical preparation method on a testing machine. A noticeable increase in the strength of the connection was observed, which was even 272%. The result of this dissertation is a composite consisting of methacrylic polymers and cellulose modified with MPMS, characterized by higher flexural strength compared to a commercial acrylic resin. On the other hand, the mechanical surface modification described in the dissertation by cutting the glaze layer in two directions and combining this method with chemical preparation of the surface with (3-methacryloxypropyl)dimethylethoxysilane allowed for an increase in the bond strength between polymerized acrylic and acrylic composite
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CAS No. : | 13731-98-1 |
Formula : | C11H22O3Si |
M.W : | 230.38 |
SMILES Code : | CC(C(OCCC[Si](C)(OCC)C)=O)=C |
MDL No. : | MFCD00053877 |
InChI Key : | JSOZORWBKQSQCJ-UHFFFAOYSA-N |
Pubchem ID : | 2759528 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H332-H335 |
Precautionary Statements: | P261-P280-P305+P351+P338 |
Tags: 13731-98-1 synthesis path| 13731-98-1 SDS| 13731-98-1 COA| 13731-98-1 purity| 13731-98-1 application| 13731-98-1 NMR| 13731-98-1 COA| 13731-98-1 structure
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P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
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P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
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P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
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P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
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P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
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P501 | Dispose of contents/container to ... |
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H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
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H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
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H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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