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Chemical Structure| 1373168-65-0 Chemical Structure| 1373168-65-0

Structure of 1373168-65-0

Chemical Structure| 1373168-65-0

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Product Details of [ 1373168-65-0 ]

CAS No. :1373168-65-0
Formula : C6H4FN3
M.W : 137.11
SMILES Code : FC1=CN=CC2=C1C=NN2

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Application In Synthesis of [ 1373168-65-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1373168-65-0 ]

[ 1373168-65-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 71902-33-5 ]
  • [ 1373168-65-0 ]
  • 2
  • [ 870234-98-3 ]
  • [ 1373168-65-0 ]
YieldReaction ConditionsOperation in experiment
With hydrazine hydrate; In water; at 0 - 55℃; for 58h;Industry scale; EXAMPLE 2: 4-Fluoro-lH-pyrazolo[3,4-c]pyridine [0086] Crude <strong>[870234-98-3]3,5-difluoroisonicotinaldehyde</strong> (2.0 kg) was suspended in DI water (6.0 L) and stirred to form a slurry. Hydrazine monohydrate (8.0 L) was cooled to a temperature of 10 to 15C. The <strong>[870234-98-3]3,5-difluoroisonicotinaldehyde</strong>/water slurry was slowly transferred to the hydrazine monohydrate to keep the internal temperature below 25C. When the addition was complete, the mixture was gradually brought to 55C and was stirred at 55C for 40 hours and was then cooled to 0C and stirred for 18 hours before being filtered. The filter cake was washed with water (2 x 1.0 L) and was dried under vacuum (< 3 in. Hg) at 35 to 40C for 24 hours to give a first crop of the title compound as an orange solid (884 g). The filtrate was extracted three times with 2-methyl THF (6.0 L). The organic layers were combined, washed with brine (4.0 L), and concentrated by rotary evaporation to give a residue which was slurried in a mixture of EtO Ac/heptane (3:2, 4.0 L) for three hours. The slurry was filtered. The filter cake was washed with a mixture of EtO Ac/heptane (3:2, 2 x 1.0 L) and dried under vacuum (< 3 in. Hg) at 35 - 40C for 24 hours to give a second crop of the title compound (206 g).
 

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